Investigation of the molecular ageing process of the long-livedbivalve Arctica islandica
The question on why we age and how ageing proceeds has occupied researchers’ minds for a long time. Demands on research of healthy ageing and geriatric diseases rise with an older growing human population. Thus, studying the mechanisms of ageing in animals with extraordinarily long lifespans could p...
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ftunivkiel:oai:macau.uni-kiel.de:diss_mods_00012245 2024-06-23T07:50:56+00:00 Investigation of the molecular ageing process of the long-livedbivalve Arctica islandica Untersuchung des molekularen Alterungsprozesses in der langlebigen Muschel Arctica islandica Gruber, Heike Rosenstiel, Philip Roeder, Thomas 2013 https://nbn-resolving.org/urn:nbn:de:gbv:8-diss-122454 https://macau.uni-kiel.de/receive/diss_mods_00012245 https://macau.uni-kiel.de/servlets/MCRFileNodeServlet/dissertation_derivate_00004871/Diss_Gruber_2013_final.pdf eng eng https://nbn-resolving.org/urn:nbn:de:gbv:8-diss-122454 https://macau.uni-kiel.de/receive/diss_mods_00012245 https://macau.uni-kiel.de/servlets/MCRFileNodeServlet/dissertation_derivate_00004871/Diss_Gruber_2013_final.pdf https://rightsstatements.org/page/InC/1.0/ info:eu-repo/semantics/openAccess thesis ddc:500 ageing Arctica islandica transcriptome gene expression ageing markers Altern Transkriptom Genexpression Alterungsmarker dissertation Text doc-type:PhDThesis 2013 ftunivkiel 2024-06-12T14:20:04Z The question on why we age and how ageing proceeds has occupied researchers’ minds for a long time. Demands on research of healthy ageing and geriatric diseases rise with an older growing human population. Thus, studying the mechanisms of ageing in animals with extraordinarily long lifespans could possibly reveal secrets to longevity and healthy ageing. In this study, a short-lived population of the bivalve mollusk Arctica islandica from the Baltic Sea (with a maximum lifespan – MLSP – of 40 years) was compared to a long-lived population from Iceland (MLSP >400 years) with respect to physiological and molecular damage parameters and gene expression. Both populations originate from two very distinct environments that may influence the ageing process of the animals. Cohorts of both populations were sampled in 2010 and sexes and ages of all animals were determined. Based on this data, ageing markers (oxidation of proteins, lipids, and nucleotides, protein stability, telomere length, telomerase activity) from selected individuals along sampled age ranges (10-36 years in the Baltic Sea and 6-226 years in Iceland) of the two populations were investigated. Oxidation to nucleotides significantly accumulated over age in both populations and did so significantly faster in the shorter-lived Baltic Sea compared to the longer-lived Iceland population regarding their absolute chronological age. Remarkably, when looking at the results in respect to the relative lifespan of each population, nucleotide damage accumulated at the same pace in both populations. Additionally, a significantly higher mean level of DNA damage was detected in the shorter-lived Baltic Sea population where frequent hypoxic and anoxic events occur and the animals are living in a warmer environment. Interestingly, significantly higher mean levels of lipid peroxidation were observed in the long-lived cold-adapted Iceland population that might result from a different lipid composition at colder temperatures. Lipid peroxidation over investigated ages, ... Doctoral or Postdoctoral Thesis Arctica islandica Iceland MACAU: Open Access Repository of Kiel University |
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Open Polar |
collection |
MACAU: Open Access Repository of Kiel University |
op_collection_id |
ftunivkiel |
language |
English |
topic |
thesis ddc:500 ageing Arctica islandica transcriptome gene expression ageing markers Altern Transkriptom Genexpression Alterungsmarker |
spellingShingle |
thesis ddc:500 ageing Arctica islandica transcriptome gene expression ageing markers Altern Transkriptom Genexpression Alterungsmarker Gruber, Heike Investigation of the molecular ageing process of the long-livedbivalve Arctica islandica |
topic_facet |
thesis ddc:500 ageing Arctica islandica transcriptome gene expression ageing markers Altern Transkriptom Genexpression Alterungsmarker |
description |
The question on why we age and how ageing proceeds has occupied researchers’ minds for a long time. Demands on research of healthy ageing and geriatric diseases rise with an older growing human population. Thus, studying the mechanisms of ageing in animals with extraordinarily long lifespans could possibly reveal secrets to longevity and healthy ageing. In this study, a short-lived population of the bivalve mollusk Arctica islandica from the Baltic Sea (with a maximum lifespan – MLSP – of 40 years) was compared to a long-lived population from Iceland (MLSP >400 years) with respect to physiological and molecular damage parameters and gene expression. Both populations originate from two very distinct environments that may influence the ageing process of the animals. Cohorts of both populations were sampled in 2010 and sexes and ages of all animals were determined. Based on this data, ageing markers (oxidation of proteins, lipids, and nucleotides, protein stability, telomere length, telomerase activity) from selected individuals along sampled age ranges (10-36 years in the Baltic Sea and 6-226 years in Iceland) of the two populations were investigated. Oxidation to nucleotides significantly accumulated over age in both populations and did so significantly faster in the shorter-lived Baltic Sea compared to the longer-lived Iceland population regarding their absolute chronological age. Remarkably, when looking at the results in respect to the relative lifespan of each population, nucleotide damage accumulated at the same pace in both populations. Additionally, a significantly higher mean level of DNA damage was detected in the shorter-lived Baltic Sea population where frequent hypoxic and anoxic events occur and the animals are living in a warmer environment. Interestingly, significantly higher mean levels of lipid peroxidation were observed in the long-lived cold-adapted Iceland population that might result from a different lipid composition at colder temperatures. Lipid peroxidation over investigated ages, ... |
author2 |
Rosenstiel, Philip Roeder, Thomas |
format |
Doctoral or Postdoctoral Thesis |
author |
Gruber, Heike |
author_facet |
Gruber, Heike |
author_sort |
Gruber, Heike |
title |
Investigation of the molecular ageing process of the long-livedbivalve Arctica islandica |
title_short |
Investigation of the molecular ageing process of the long-livedbivalve Arctica islandica |
title_full |
Investigation of the molecular ageing process of the long-livedbivalve Arctica islandica |
title_fullStr |
Investigation of the molecular ageing process of the long-livedbivalve Arctica islandica |
title_full_unstemmed |
Investigation of the molecular ageing process of the long-livedbivalve Arctica islandica |
title_sort |
investigation of the molecular ageing process of the long-livedbivalve arctica islandica |
publishDate |
2013 |
url |
https://nbn-resolving.org/urn:nbn:de:gbv:8-diss-122454 https://macau.uni-kiel.de/receive/diss_mods_00012245 https://macau.uni-kiel.de/servlets/MCRFileNodeServlet/dissertation_derivate_00004871/Diss_Gruber_2013_final.pdf |
genre |
Arctica islandica Iceland |
genre_facet |
Arctica islandica Iceland |
op_relation |
https://nbn-resolving.org/urn:nbn:de:gbv:8-diss-122454 https://macau.uni-kiel.de/receive/diss_mods_00012245 https://macau.uni-kiel.de/servlets/MCRFileNodeServlet/dissertation_derivate_00004871/Diss_Gruber_2013_final.pdf |
op_rights |
https://rightsstatements.org/page/InC/1.0/ info:eu-repo/semantics/openAccess |
_version_ |
1802641884313550848 |