Ancient human genome sequence of an extinct Palaeo-Eskimo
We report here the genome sequence of an ancient human. Obtained from ∼4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20×, we recover 79% of the diploid genome, an amount close to...
Published in: | Nature |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | unknown |
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Macmilan Publishers
2014
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Online Access: | http://hdl.handle.net/1808/13628 https://doi.org/10.1038/nature08835 |
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The University of Kansas: KU ScholarWorks |
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We report here the genome sequence of an ancient human. Obtained from ∼4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20×, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit. Centre for Geogenetics, the Copenhagen branch of the Sino-Danish Genomic Centre and Wilhelm Johannsen Centre for Functional Genome Research were supported by Danish National Research Foundation, the Lundbeck Foundation, and the Danish Agency for Science, Technology and Innovation. Center for Biological Sequence Analysis was supported by Villum Kann Rasmussen Fonden; Center for Protein Reseaerch by the Novo Nordisk Foundation. E.W. thanks F. Paulsen for financial support to initiate the project. E.M. thanks Estonian Science Foundation for grant 7858, and R.V. EC DGR for FP7 Ecogene grant 205419 and EU RDF through Centre of Excellence in Genomics grant. J.W. thanks the Shenzhen Municipal Government, the Yantian District local government of Shenzhen, the National Natural Science Foundation of China (30725008), Ole Romer grant from the Danish Natural Science Research Council, the Solexa project (272-07-0196), and Danish Strategic Research Council (2106-07-0021). M.Bu. acknowledges the support of the ... |
format |
Article in Journal/Newspaper |
author |
Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jakob Skou Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek Bertalan, Marcelo Nielsen, Kasper Gilbert, M. Thomas P. Wang, Yong Raghavan, Maanasa Campos, Paula F. Kamp, Hanne Munkholm Wilson, Andrew S. Gledhill, Andrew Tridico, Silvana Bunce, Michael Lorenzen, Eline D. Binladen, Jonas Guo, Xiaosen Zhao, Jing Zhang, Xiuqing Zhang, Hao Li, Zhuo Chen, Minfeng Orlando, Ludovic Kristiansen, Karsten Bak, Mads Tommerup, Niels Bendixen, Christian Pierre, Tracey L. Gronnow, Bjarne Meldgaard, Morten Andreasen, Claus Fedorova, Sardana A. Osipova, Ludmila P. Higham, Thomas F G. Ramsey, Christopher Bronk Hansen, Thomas v. O. Nielsen, Finn C. Crawford, Michael H. Brunak, Soren Sicheritz-Ponten, Thomas Villems, Richard Nielsen, Rasmus Krogh, Anders |
spellingShingle |
Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jakob Skou Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek Bertalan, Marcelo Nielsen, Kasper Gilbert, M. Thomas P. Wang, Yong Raghavan, Maanasa Campos, Paula F. Kamp, Hanne Munkholm Wilson, Andrew S. Gledhill, Andrew Tridico, Silvana Bunce, Michael Lorenzen, Eline D. Binladen, Jonas Guo, Xiaosen Zhao, Jing Zhang, Xiuqing Zhang, Hao Li, Zhuo Chen, Minfeng Orlando, Ludovic Kristiansen, Karsten Bak, Mads Tommerup, Niels Bendixen, Christian Pierre, Tracey L. Gronnow, Bjarne Meldgaard, Morten Andreasen, Claus Fedorova, Sardana A. Osipova, Ludmila P. Higham, Thomas F G. Ramsey, Christopher Bronk Hansen, Thomas v. O. Nielsen, Finn C. Crawford, Michael H. Brunak, Soren Sicheritz-Ponten, Thomas Villems, Richard Nielsen, Rasmus Krogh, Anders Ancient human genome sequence of an extinct Palaeo-Eskimo |
author_facet |
Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jakob Skou Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek Bertalan, Marcelo Nielsen, Kasper Gilbert, M. Thomas P. Wang, Yong Raghavan, Maanasa Campos, Paula F. Kamp, Hanne Munkholm Wilson, Andrew S. Gledhill, Andrew Tridico, Silvana Bunce, Michael Lorenzen, Eline D. Binladen, Jonas Guo, Xiaosen Zhao, Jing Zhang, Xiuqing Zhang, Hao Li, Zhuo Chen, Minfeng Orlando, Ludovic Kristiansen, Karsten Bak, Mads Tommerup, Niels Bendixen, Christian Pierre, Tracey L. Gronnow, Bjarne Meldgaard, Morten Andreasen, Claus Fedorova, Sardana A. Osipova, Ludmila P. Higham, Thomas F G. Ramsey, Christopher Bronk Hansen, Thomas v. O. Nielsen, Finn C. Crawford, Michael H. Brunak, Soren Sicheritz-Ponten, Thomas Villems, Richard Nielsen, Rasmus Krogh, Anders |
author_sort |
Rasmussen, Morten |
title |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_short |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_full |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_fullStr |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_full_unstemmed |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_sort |
ancient human genome sequence of an extinct palaeo-eskimo |
publisher |
Macmilan Publishers |
publishDate |
2014 |
url |
http://hdl.handle.net/1808/13628 https://doi.org/10.1038/nature08835 |
long_lat |
ENVELOPE(-64.084,-64.084,-65.248,-65.248) |
geographic |
Greenland Rasmussen |
geographic_facet |
Greenland Rasmussen |
genre |
eskimo* Greenland inuit permafrost Siberia |
genre_facet |
eskimo* Greenland inuit permafrost Siberia |
op_relation |
Rasmussen, Morten, Yingrui Li, Stinus Lindgreen, Jakob Skou Pedersen, Anders Albrechtsen, Ida Moltke, Mait Metspalu, Ene Metspalu, Toomas Kivisild, Ramneek Gupta, Marcelo Bertalan, Kasper Nielsen, M. Thomas P. Gilbert, Yong Wang, Maanasa Raghavan, Paula F. Campos, Hanne Munkholm Kamp, Andrew S. Wilson, Andrew Gledhill, Silvana Tridico, Michael Bunce, Eline D. Lorenzen, Jonas Binladen, Xiaosen Guo, Jing Zhao, Xiuqing Zhang, Hao Zhang, Zhuo Li, Minfeng Chen, Ludovic Orlando, Karsten Kristiansen, Mads Bak, Niels Tommerup, Christian Bendixen, Tracey L. Pierre, Bjarne Grønnow, Morten Meldgaard, Claus Andreasen, Sardana A. Fedorova, Ludmila P. Osipova, Thomas F. G. Higham, Christopher Bronk Ramsey, Thomas v. O. Hansen, Finn C. Nielsen, Michael H. Crawford, Søren Brunak, Thomas Sicheritz-Pontén, Richard Villems, Rasmus Nielsen, Anders Krogh, Jun Wang, and Eske Willerslev (2010) "Ancient human genome sequence of an extinct Palaeop-Eskimo." Nature. Feb 11, 2010; 463(7282): 757–762. http://dx.doi.org/10.1038/nature08835 http://hdl.handle.net/1808/13628 doi:10.1038/nature08835 |
op_rights |
This paper is distributed under the terms of the Creative Commons Attribution-Non-Commercial-Share-Alike license, and is freely available to all readers at www.nature.com/nature. http://creativecommons.org/licenses/by-nc-sa/4.0/ openAccess |
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CC-BY-NC-SA |
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https://doi.org/10.1038/nature08835 |
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Nature |
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463 |
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7282 |
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757 |
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ftunivkansas:oai:kuscholarworks.ku.edu:1808/13628 2023-05-15T16:06:30+02:00 Ancient human genome sequence of an extinct Palaeo-Eskimo Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jakob Skou Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek Bertalan, Marcelo Nielsen, Kasper Gilbert, M. Thomas P. Wang, Yong Raghavan, Maanasa Campos, Paula F. Kamp, Hanne Munkholm Wilson, Andrew S. Gledhill, Andrew Tridico, Silvana Bunce, Michael Lorenzen, Eline D. Binladen, Jonas Guo, Xiaosen Zhao, Jing Zhang, Xiuqing Zhang, Hao Li, Zhuo Chen, Minfeng Orlando, Ludovic Kristiansen, Karsten Bak, Mads Tommerup, Niels Bendixen, Christian Pierre, Tracey L. Gronnow, Bjarne Meldgaard, Morten Andreasen, Claus Fedorova, Sardana A. Osipova, Ludmila P. Higham, Thomas F G. Ramsey, Christopher Bronk Hansen, Thomas v. O. Nielsen, Finn C. Crawford, Michael H. Brunak, Soren Sicheritz-Ponten, Thomas Villems, Richard Nielsen, Rasmus Krogh, Anders 2014-05-06T18:39:33Z http://hdl.handle.net/1808/13628 https://doi.org/10.1038/nature08835 unknown Macmilan Publishers Rasmussen, Morten, Yingrui Li, Stinus Lindgreen, Jakob Skou Pedersen, Anders Albrechtsen, Ida Moltke, Mait Metspalu, Ene Metspalu, Toomas Kivisild, Ramneek Gupta, Marcelo Bertalan, Kasper Nielsen, M. Thomas P. Gilbert, Yong Wang, Maanasa Raghavan, Paula F. Campos, Hanne Munkholm Kamp, Andrew S. Wilson, Andrew Gledhill, Silvana Tridico, Michael Bunce, Eline D. Lorenzen, Jonas Binladen, Xiaosen Guo, Jing Zhao, Xiuqing Zhang, Hao Zhang, Zhuo Li, Minfeng Chen, Ludovic Orlando, Karsten Kristiansen, Mads Bak, Niels Tommerup, Christian Bendixen, Tracey L. Pierre, Bjarne Grønnow, Morten Meldgaard, Claus Andreasen, Sardana A. Fedorova, Ludmila P. Osipova, Thomas F. G. Higham, Christopher Bronk Ramsey, Thomas v. O. Hansen, Finn C. Nielsen, Michael H. Crawford, Søren Brunak, Thomas Sicheritz-Pontén, Richard Villems, Rasmus Nielsen, Anders Krogh, Jun Wang, and Eske Willerslev (2010) "Ancient human genome sequence of an extinct Palaeop-Eskimo." Nature. Feb 11, 2010; 463(7282): 757–762. http://dx.doi.org/10.1038/nature08835 http://hdl.handle.net/1808/13628 doi:10.1038/nature08835 This paper is distributed under the terms of the Creative Commons Attribution-Non-Commercial-Share-Alike license, and is freely available to all readers at www.nature.com/nature. http://creativecommons.org/licenses/by-nc-sa/4.0/ openAccess CC-BY-NC-SA Article 2014 ftunivkansas https://doi.org/10.1038/nature08835 2022-08-26T13:14:19Z We report here the genome sequence of an ancient human. Obtained from ∼4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20×, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit. Centre for Geogenetics, the Copenhagen branch of the Sino-Danish Genomic Centre and Wilhelm Johannsen Centre for Functional Genome Research were supported by Danish National Research Foundation, the Lundbeck Foundation, and the Danish Agency for Science, Technology and Innovation. Center for Biological Sequence Analysis was supported by Villum Kann Rasmussen Fonden; Center for Protein Reseaerch by the Novo Nordisk Foundation. E.W. thanks F. Paulsen for financial support to initiate the project. E.M. thanks Estonian Science Foundation for grant 7858, and R.V. EC DGR for FP7 Ecogene grant 205419 and EU RDF through Centre of Excellence in Genomics grant. J.W. thanks the Shenzhen Municipal Government, the Yantian District local government of Shenzhen, the National Natural Science Foundation of China (30725008), Ole Romer grant from the Danish Natural Science Research Council, the Solexa project (272-07-0196), and Danish Strategic Research Council (2106-07-0021). M.Bu. acknowledges the support of the ... Article in Journal/Newspaper eskimo* Greenland inuit permafrost Siberia The University of Kansas: KU ScholarWorks Greenland Rasmussen ENVELOPE(-64.084,-64.084,-65.248,-65.248) Nature 463 7282 757 762 |