Do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed Atlantic salmon?
The substitution of fish oil and fishmeal with plant-based ingredients in commercial aquafeeds for Atlantic salmon, may introduce novel contaminants that have not previously been associated with farmed fish. The organophosphate pesticide pirimiphos-methyl (PM) is one of the novel contaminants that i...
Published in: | Food Additives & Contaminants: Part A |
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Online Access: | http://hdl.handle.net/10234/191190 https://doi.org/10.1080/19440049.2020.1829717 |
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ftunivjaumeirep:oai:repositori.uji.es:10234/191190 2023-05-15T15:29:58+02:00 Do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed Atlantic salmon? Berntssen, Marc H. G. Hoogenveen, Rudolf Rosenlund, Grethe Garlito Molina, Borja Zeilmaker, Marco J. Norwegian Research Council (NFR) “AQUASAFE” (254807) 2021-01-13T08:15:41Z application/pdf http://hdl.handle.net/10234/191190 https://doi.org/10.1080/19440049.2020.1829717 eng eng Taylor & Francis Group Food Additives & Contaminants: Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment, 2020, vol. 37 Norwegian Research Council (NFR) [“AQUASAFE” (254807)] https://www.tandfonline.com/doi/full/10.1080/19440049.2020.1829717 Marc H.G. Berntssen, Rudolf Hoogenveen, Grethe Rosenlund, Borja Garlito & Marco J. Zeilmaker (2020) Do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed Atlantic salmon?, Food Additives & Contaminants: Part A, 37:12, 2109-2122, DOI:10.1080/19440049.2020.1829717 1944-0049 http://hdl.handle.net/10234/191190 doi:10.1080/19440049.2020.1829717 © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess CC-BY-NC-ND exposure modelling risk assessment - modelling toxicology - metabolism animal study feeding pesticide residues – organophosphorus animal feedingstuffs fish info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2021 ftunivjaumeirep https://doi.org/10.1080/19440049.2020.1829717 2021-08-11T19:51:52Z The substitution of fish oil and fishmeal with plant-based ingredients in commercial aquafeeds for Atlantic salmon, may introduce novel contaminants that have not previously been associated with farmed fish. The organophosphate pesticide pirimiphos-methyl (PM) is one of the novel contaminants that is most prevalent in commercial salmon feed. In this study, the feed-to-fillet transfer of dietary PM and its main metabolites was investigated in Atlantic salmon fillet. Based on the experimental determined PM and metabolite uptake, metabolisation, and elimination kinetics, a physiologically based toxicokinetic (PBTK) compartmental model was developed. Fish fed PM had a relatively low (~4%) PM retention and two main metabolites (2-DAMP and Desethyl-PM) were identified in liver, muscle, kidney and bile. The absence of more metabolised forms of 2-DAMP and Desethyl-PM in Atlantic salmon indicates different metabolism in cold-water fish compared to previous studies on ruminants. The model was used to simulate the long term (>1.5 years) feed-to-fillet transfer of PM + metabolite in Atlantic salmon under realistic farming conditions including seasonal fluctuations in feed intake, growth, and fat deposition in muscle tissue. The model predictions show that with the constant presence of the highest observed PM concentration in commercial salmon feed, fillet PM+ metabolite levels were approximately 5 nmol kg−1, with highest levels for the metabolite 2-DAMP. No EU maximum residue levels (MRL) for PM and its main metabolites exist in seafood to date, but the predicted levels were lower than the MRL for PM in swine of 32.7 nmol kg−1. Article in Journal/Newspaper Atlantic salmon Repositori Universitat Jaume I (Repositorio UJI) Food Additives & Contaminants: Part A 37 12 2109 2122 |
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Open Polar |
collection |
Repositori Universitat Jaume I (Repositorio UJI) |
op_collection_id |
ftunivjaumeirep |
language |
English |
topic |
exposure modelling risk assessment - modelling toxicology - metabolism animal study feeding pesticide residues – organophosphorus animal feedingstuffs fish |
spellingShingle |
exposure modelling risk assessment - modelling toxicology - metabolism animal study feeding pesticide residues – organophosphorus animal feedingstuffs fish Berntssen, Marc H. G. Hoogenveen, Rudolf Rosenlund, Grethe Garlito Molina, Borja Zeilmaker, Marco J. Do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed Atlantic salmon? |
topic_facet |
exposure modelling risk assessment - modelling toxicology - metabolism animal study feeding pesticide residues – organophosphorus animal feedingstuffs fish |
description |
The substitution of fish oil and fishmeal with plant-based ingredients in commercial aquafeeds for Atlantic salmon, may introduce novel contaminants that have not previously been associated with farmed fish. The organophosphate pesticide pirimiphos-methyl (PM) is one of the novel contaminants that is most prevalent in commercial salmon feed. In this study, the feed-to-fillet transfer of dietary PM and its main metabolites was investigated in Atlantic salmon fillet. Based on the experimental determined PM and metabolite uptake, metabolisation, and elimination kinetics, a physiologically based toxicokinetic (PBTK) compartmental model was developed. Fish fed PM had a relatively low (~4%) PM retention and two main metabolites (2-DAMP and Desethyl-PM) were identified in liver, muscle, kidney and bile. The absence of more metabolised forms of 2-DAMP and Desethyl-PM in Atlantic salmon indicates different metabolism in cold-water fish compared to previous studies on ruminants. The model was used to simulate the long term (>1.5 years) feed-to-fillet transfer of PM + metabolite in Atlantic salmon under realistic farming conditions including seasonal fluctuations in feed intake, growth, and fat deposition in muscle tissue. The model predictions show that with the constant presence of the highest observed PM concentration in commercial salmon feed, fillet PM+ metabolite levels were approximately 5 nmol kg−1, with highest levels for the metabolite 2-DAMP. No EU maximum residue levels (MRL) for PM and its main metabolites exist in seafood to date, but the predicted levels were lower than the MRL for PM in swine of 32.7 nmol kg−1. |
author2 |
Norwegian Research Council (NFR) “AQUASAFE” (254807) |
format |
Article in Journal/Newspaper |
author |
Berntssen, Marc H. G. Hoogenveen, Rudolf Rosenlund, Grethe Garlito Molina, Borja Zeilmaker, Marco J. |
author_facet |
Berntssen, Marc H. G. Hoogenveen, Rudolf Rosenlund, Grethe Garlito Molina, Borja Zeilmaker, Marco J. |
author_sort |
Berntssen, Marc H. G. |
title |
Do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed Atlantic salmon? |
title_short |
Do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed Atlantic salmon? |
title_full |
Do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed Atlantic salmon? |
title_fullStr |
Do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed Atlantic salmon? |
title_full_unstemmed |
Do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed Atlantic salmon? |
title_sort |
do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed atlantic salmon? |
publisher |
Taylor & Francis Group |
publishDate |
2021 |
url |
http://hdl.handle.net/10234/191190 https://doi.org/10.1080/19440049.2020.1829717 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
Food Additives & Contaminants: Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment, 2020, vol. 37 Norwegian Research Council (NFR) [“AQUASAFE” (254807)] https://www.tandfonline.com/doi/full/10.1080/19440049.2020.1829717 Marc H.G. Berntssen, Rudolf Hoogenveen, Grethe Rosenlund, Borja Garlito & Marco J. Zeilmaker (2020) Do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed Atlantic salmon?, Food Additives & Contaminants: Part A, 37:12, 2109-2122, DOI:10.1080/19440049.2020.1829717 1944-0049 http://hdl.handle.net/10234/191190 doi:10.1080/19440049.2020.1829717 |
op_rights |
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1080/19440049.2020.1829717 |
container_title |
Food Additives & Contaminants: Part A |
container_volume |
37 |
container_issue |
12 |
container_start_page |
2109 |
op_container_end_page |
2122 |
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1766360415336398848 |