LC-MS/MS method for the determination of organophosphorus pesticides and their metabolites in salmon and zebrafish fed with plant-based feed ingredients
This is a pre-print of an article published in Analytical and Bioanalytical Chemistry. The final authenticated version is available online at:https://doi.org/10.1007/s00216-019-02104-6 The composition of Atlantic salmon feed has changed considerably over the last two decades from being marine-based...
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ftunivjaumeirep:oai:repositori.uji.es:10234/187077 2023-05-15T15:30:57+02:00 LC-MS/MS method for the determination of organophosphorus pesticides and their metabolites in salmon and zebrafish fed with plant-based feed ingredients Garlito Molina, Borja Ibáñez, Maria Portoles, Tania Serrano, Roque Amlund, Heidi Lundebye, Anne-Katrine Sanden, Monica Berntssen, Marc H. G. Hernandez, Felix 2020-03-24T10:44:03Z application/pdf http://hdl.handle.net/10234/187077 https://doi.org/10.1007/s00216-019-02104-6 eng eng Springer Analytical and bioanalytical chemistry, 2019, vol. 411, no 27 Norwegian Research Council (NFR) project “AQUASAFE” (254807) https://link.springer.com/article/10.1007/s00216-019-02104-6 arlito, B., Ibáñez, M., Portolés, T. et al. LC-MS/MS method for the determination of organophosphorus pesticides and their metabolites in salmon and zebrafish fed with plant-based feed ingredients. Anal Bioanal Chem 411, 7281–7291 (2019). https://doi.org/10.1007/s00216-019-02104-6 1618-2642 1618-2650 http://hdl.handle.net/10234/187077 https://doi.org/10.1007/s00216-019-02104-6 © Springer Nature http://rightsstatements.org/vocab/InC/1.0/ info:eu-repo/semantics/openAccess chlorpyrifos-methyl pirimiphos-methyl metabolites Atlantic salmon zebrafish LC-MS/MS info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/submittedVersion 2020 ftunivjaumeirep https://doi.org/10.1007/s00216-019-02104-6 2022-05-17T23:04:40Z This is a pre-print of an article published in Analytical and Bioanalytical Chemistry. The final authenticated version is available online at:https://doi.org/10.1007/s00216-019-02104-6 The composition of Atlantic salmon feed has changed considerably over the last two decades from being marine-based (fishmeal and fish oil) to mainly containing plant ingredients. Consequently, concern related to traditional persistent contaminants typically associated with fish-based feed has been replaced by other potential contaminants not previously associated with salmon farming. This is the case for many pesticides, which are used worldwide to increase food production, and may be present in plant ingredients. Earlier studies have identified two organophosphorus pesticides, chlorpyrifos-methyl and pirimiphos-methyl, in plant ingredients used for aquafeed production. In the present study, we developed a reliable and sensitive analytical method, based on liquid chromatography coupled to tandem mass spectrometry, for the determination of these pesticides and their main metabolites in warm water (zebrafish) and cold water (Atlantic salmon) species, where possible differences in metabolites could be expected. The method was tested in whole zebrafish and in different salmon tissues, such as muscle, bile, kidney, fat, and liver. The final objective of this work was to assess kinetics of chlorpyrifos-methyl and pirimiphos-methyl and their main metabolites in fish tissue, in order to fill the knowledge gaps on these metabolites in fish tissues when fed over prolonged time. Article in Journal/Newspaper Atlantic salmon Repositori Universitat Jaume I (Repositorio UJI) Analytical and Bioanalytical Chemistry 411 27 7281 7291 |
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Open Polar |
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Repositori Universitat Jaume I (Repositorio UJI) |
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ftunivjaumeirep |
language |
English |
topic |
chlorpyrifos-methyl pirimiphos-methyl metabolites Atlantic salmon zebrafish LC-MS/MS |
spellingShingle |
chlorpyrifos-methyl pirimiphos-methyl metabolites Atlantic salmon zebrafish LC-MS/MS Garlito Molina, Borja Ibáñez, Maria Portoles, Tania Serrano, Roque Amlund, Heidi Lundebye, Anne-Katrine Sanden, Monica Berntssen, Marc H. G. Hernandez, Felix LC-MS/MS method for the determination of organophosphorus pesticides and their metabolites in salmon and zebrafish fed with plant-based feed ingredients |
topic_facet |
chlorpyrifos-methyl pirimiphos-methyl metabolites Atlantic salmon zebrafish LC-MS/MS |
description |
This is a pre-print of an article published in Analytical and Bioanalytical Chemistry. The final authenticated version is available online at:https://doi.org/10.1007/s00216-019-02104-6 The composition of Atlantic salmon feed has changed considerably over the last two decades from being marine-based (fishmeal and fish oil) to mainly containing plant ingredients. Consequently, concern related to traditional persistent contaminants typically associated with fish-based feed has been replaced by other potential contaminants not previously associated with salmon farming. This is the case for many pesticides, which are used worldwide to increase food production, and may be present in plant ingredients. Earlier studies have identified two organophosphorus pesticides, chlorpyrifos-methyl and pirimiphos-methyl, in plant ingredients used for aquafeed production. In the present study, we developed a reliable and sensitive analytical method, based on liquid chromatography coupled to tandem mass spectrometry, for the determination of these pesticides and their main metabolites in warm water (zebrafish) and cold water (Atlantic salmon) species, where possible differences in metabolites could be expected. The method was tested in whole zebrafish and in different salmon tissues, such as muscle, bile, kidney, fat, and liver. The final objective of this work was to assess kinetics of chlorpyrifos-methyl and pirimiphos-methyl and their main metabolites in fish tissue, in order to fill the knowledge gaps on these metabolites in fish tissues when fed over prolonged time. |
format |
Article in Journal/Newspaper |
author |
Garlito Molina, Borja Ibáñez, Maria Portoles, Tania Serrano, Roque Amlund, Heidi Lundebye, Anne-Katrine Sanden, Monica Berntssen, Marc H. G. Hernandez, Felix |
author_facet |
Garlito Molina, Borja Ibáñez, Maria Portoles, Tania Serrano, Roque Amlund, Heidi Lundebye, Anne-Katrine Sanden, Monica Berntssen, Marc H. G. Hernandez, Felix |
author_sort |
Garlito Molina, Borja |
title |
LC-MS/MS method for the determination of organophosphorus pesticides and their metabolites in salmon and zebrafish fed with plant-based feed ingredients |
title_short |
LC-MS/MS method for the determination of organophosphorus pesticides and their metabolites in salmon and zebrafish fed with plant-based feed ingredients |
title_full |
LC-MS/MS method for the determination of organophosphorus pesticides and their metabolites in salmon and zebrafish fed with plant-based feed ingredients |
title_fullStr |
LC-MS/MS method for the determination of organophosphorus pesticides and their metabolites in salmon and zebrafish fed with plant-based feed ingredients |
title_full_unstemmed |
LC-MS/MS method for the determination of organophosphorus pesticides and their metabolites in salmon and zebrafish fed with plant-based feed ingredients |
title_sort |
lc-ms/ms method for the determination of organophosphorus pesticides and their metabolites in salmon and zebrafish fed with plant-based feed ingredients |
publisher |
Springer |
publishDate |
2020 |
url |
http://hdl.handle.net/10234/187077 https://doi.org/10.1007/s00216-019-02104-6 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
Analytical and bioanalytical chemistry, 2019, vol. 411, no 27 Norwegian Research Council (NFR) project “AQUASAFE” (254807) https://link.springer.com/article/10.1007/s00216-019-02104-6 arlito, B., Ibáñez, M., Portolés, T. et al. LC-MS/MS method for the determination of organophosphorus pesticides and their metabolites in salmon and zebrafish fed with plant-based feed ingredients. Anal Bioanal Chem 411, 7281–7291 (2019). https://doi.org/10.1007/s00216-019-02104-6 1618-2642 1618-2650 http://hdl.handle.net/10234/187077 https://doi.org/10.1007/s00216-019-02104-6 |
op_rights |
© Springer Nature http://rightsstatements.org/vocab/InC/1.0/ info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1007/s00216-019-02104-6 |
container_title |
Analytical and Bioanalytical Chemistry |
container_volume |
411 |
container_issue |
27 |
container_start_page |
7281 |
op_container_end_page |
7291 |
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1766361427218530304 |