Is Promiscuous CALB a Good Scaffold for Designing New Epoxidases?

• Published in: Molecules
• Main Authors: Bordes, Isabel, Recatalá, José, Świderek, Katarzyna, Moliner, Vicent
• Format: Article in Journal/Newspaper
• Language: English
• Published: MDPI 2016
• Subjects: Candida antarctica lipase B; CALB; epoxide hydrolase; sEH; reaction mechanism; trans-diphenylpropene oxide; enzyme promiscuity; catalysis; quantum cluster models; Jaume; Antarc*; Antarctica
• Online Access: http://hdl.handle.net/10234/159486; https://doi.org/10.3390/molecules201017789

Candida Antarctica lipase B (CALB) is a well-known enzyme, especially because of its promiscuous activity. Due to its properties, CALB was widely used as a benchmark for designing new catalysts for important organic reactions. The active site of CALB is very similar to that of soluble epoxide hydrol...