Elucidating evolutionary processes in three threatened carnivores: genetic substructure, admixture, and cancer susceptibility
Advanced genomic techniques can be used to understand threats to global biodiversity and to promote ecosystem conservation. Population structure, migration, admixture, and the genetic basis of adaptive variation can be inferred in small, isolated, and declining populations of interest, thereby addin...
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ftunividahodc:oai:digital.lib.uidaho.edu:etd/2030 2023-11-12T04:15:44+01:00 Elucidating evolutionary processes in three threatened carnivores: genetic substructure, admixture, and cancer susceptibility Hendricks, Sarah Hohenlohe, Paul 2019-05 PDF http://digital.lib.uidaho.edu/cdm/ref/collection/etd/id/2030 en eng Hendricks_idaho_0089E_11553 http://digital.lib.uidaho.edu/cdm/ref/collection/etd/id/2030 http://rightsstatements.org/vocab/InC-EDU/1.0/ Conservation biology Evolution & development Genetics Text 2019 ftunividahodc 2023-10-27T10:31:43Z Advanced genomic techniques can be used to understand threats to global biodiversity and to promote ecosystem conservation. Population structure, migration, admixture, and the genetic basis of adaptive variation can be inferred in small, isolated, and declining populations of interest, thereby adding knowledge necessary for appropriate conservation planning. Here, I present three case examples to illustrate genomics’ potential to influence the management of wild populations. First, Tasmanian devils (Sarcophilus harrisii) face a combination of threats to persistence, including devil facial tumor disease (DFTD), an epidemic transmissible cancer. I used RAD sequencing to investigate genome-wide patterns of genetic diversity and geographic population structure. Our results refine the geographic extent of the zone of mixed ancestry and substructure within it. DFTD has spread across all genetic clusters, but recent evidence points to a genomic response to selection imposed by DFTD. Any allelic variation for resistance to DFTD may be able to spread across the devil population, and/or be present as standing variation in both genetic regions. This can inform the management of genetic variation that existed in pre-diseased populations of the species. Second, wolves (Canis lupus) have naturally reestablished in the Pacific northwest region of North America. I used targeted capture sequencing to acquire SNP data from which I inferred population structure and ancestry. The wolves in Washington state represent an admixed population between the inland Northern Rocky Mountain wolf and the coastal rainforest wolf. Given this admixture, conservation status and management could be impacted if other coastal wolf populations continue to decline in size. Third, Catalina Island (SCA) foxes (Urocyon littoralis catalinae) have a high prevalence of ear canal (ceruminous gland) tumors that appear to be associated with inflammation from chronic ear mite (Otodectes) infections. I tested the hypothesis that the remarkably high incidence of ... Text Canis lupus Mite University of Idaho Library: Digital Initiatives |
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University of Idaho Library: Digital Initiatives |
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English |
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Conservation biology Evolution & development Genetics |
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Conservation biology Evolution & development Genetics Hendricks, Sarah Elucidating evolutionary processes in three threatened carnivores: genetic substructure, admixture, and cancer susceptibility |
topic_facet |
Conservation biology Evolution & development Genetics |
description |
Advanced genomic techniques can be used to understand threats to global biodiversity and to promote ecosystem conservation. Population structure, migration, admixture, and the genetic basis of adaptive variation can be inferred in small, isolated, and declining populations of interest, thereby adding knowledge necessary for appropriate conservation planning. Here, I present three case examples to illustrate genomics’ potential to influence the management of wild populations. First, Tasmanian devils (Sarcophilus harrisii) face a combination of threats to persistence, including devil facial tumor disease (DFTD), an epidemic transmissible cancer. I used RAD sequencing to investigate genome-wide patterns of genetic diversity and geographic population structure. Our results refine the geographic extent of the zone of mixed ancestry and substructure within it. DFTD has spread across all genetic clusters, but recent evidence points to a genomic response to selection imposed by DFTD. Any allelic variation for resistance to DFTD may be able to spread across the devil population, and/or be present as standing variation in both genetic regions. This can inform the management of genetic variation that existed in pre-diseased populations of the species. Second, wolves (Canis lupus) have naturally reestablished in the Pacific northwest region of North America. I used targeted capture sequencing to acquire SNP data from which I inferred population structure and ancestry. The wolves in Washington state represent an admixed population between the inland Northern Rocky Mountain wolf and the coastal rainforest wolf. Given this admixture, conservation status and management could be impacted if other coastal wolf populations continue to decline in size. Third, Catalina Island (SCA) foxes (Urocyon littoralis catalinae) have a high prevalence of ear canal (ceruminous gland) tumors that appear to be associated with inflammation from chronic ear mite (Otodectes) infections. I tested the hypothesis that the remarkably high incidence of ... |
author2 |
Hohenlohe, Paul |
format |
Text |
author |
Hendricks, Sarah |
author_facet |
Hendricks, Sarah |
author_sort |
Hendricks, Sarah |
title |
Elucidating evolutionary processes in three threatened carnivores: genetic substructure, admixture, and cancer susceptibility |
title_short |
Elucidating evolutionary processes in three threatened carnivores: genetic substructure, admixture, and cancer susceptibility |
title_full |
Elucidating evolutionary processes in three threatened carnivores: genetic substructure, admixture, and cancer susceptibility |
title_fullStr |
Elucidating evolutionary processes in three threatened carnivores: genetic substructure, admixture, and cancer susceptibility |
title_full_unstemmed |
Elucidating evolutionary processes in three threatened carnivores: genetic substructure, admixture, and cancer susceptibility |
title_sort |
elucidating evolutionary processes in three threatened carnivores: genetic substructure, admixture, and cancer susceptibility |
publishDate |
2019 |
url |
http://digital.lib.uidaho.edu/cdm/ref/collection/etd/id/2030 |
genre |
Canis lupus Mite |
genre_facet |
Canis lupus Mite |
op_relation |
Hendricks_idaho_0089E_11553 http://digital.lib.uidaho.edu/cdm/ref/collection/etd/id/2030 |
op_rights |
http://rightsstatements.org/vocab/InC-EDU/1.0/ |
_version_ |
1782333004443549696 |