Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: Prevalence in Asian populations and analysis of association with nasopharyngeal cancer
The FUS2 gene, encoding a novel cytoplasmic acetyltransferase, resides in the tumor suppressor gene region on human chromosome 3p21.3 and is considered a promising candidate tumor suppressor gene. We have identified a new single nucleotide polymorphism (SNP), c767A/T, in the coding region of the gen...
Published in: | Molecular and Cellular Probes |
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Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymcpr
2004
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Online Access: | https://doi.org/10.1016/j.mcp.2003.09.002 http://hdl.handle.net/10722/150788 |
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ftunivhongkonghu:oai:hub.hku.hk:10722/150788 2023-05-15T16:55:15+02:00 Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: Prevalence in Asian populations and analysis of association with nasopharyngeal cancer Qian, CN Lerman, MI Tean Teh, B Godbole, S Zabarovsky, ER Kashuba, V Hu, LF Voevoda, M Dean, M Stanbridge, E Guo, X Li Lung, M Moody, M Fivash, M Duh, FM 2004 https://doi.org/10.1016/j.mcp.2003.09.002 http://hdl.handle.net/10722/150788 eng eng Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymcpr United Kingdom Molecular and Cellular Probes http://www.scopus.com/mlt/select.url?eid=2-s2.0-10744221645&selection=ref&src=s&origin=recordpage Molecular And Cellular Probes, 2004, v. 18 n. 1, p. 39-44 doi:10.1016/j.mcp.2003.09.002 44 WOS:000220161300005 0890-8508 1 15036368 eid_2-s2.0-10744221645 39 http://hdl.handle.net/10722/150788 18 Acetyltransferases - Genetics - Physiology Asia - Epidemiology - Ethnology Chromosomes Human Pair 3 Endemic Diseases Gene Frequency Genes Tumor Suppressor Humans Nasopharyngeal Neoplasms - Ethnology - Genetics Polymorphism Single Nucleotide Prevalence Protein Structure Tertiary Article 2004 ftunivhongkonghu https://doi.org/10.1016/j.mcp.2003.09.002 2023-01-14T15:43:20Z The FUS2 gene, encoding a novel cytoplasmic acetyltransferase, resides in the tumor suppressor gene region on human chromosome 3p21.3 and is considered a promising candidate tumor suppressor gene. We have identified a new single nucleotide polymorphism (SNP), c767A/T, in the coding region of the gene. The polymorphism leads to a non-conservative amino acid change (R222W) located between the acetyltransferase (GNAT) and the proline-rich domains of the protein. We have analyzed 254 subjects included in 14 sub-populations. The occurrence of the SNP varies with the ethnicity of the population, suggesting that this SNP could be a valuable biomarker for population genetics. It is most prevalent in various Asian populations (T allele frequency>0.54), followed by the Canadian polar Inuit (T allele frequency=0.3), African American (T allele frequency=0.17), and Caucasian population (T allele frequency=0.1). Since nasopharyngeal carcinoma (NPC) is frequent in Southern China, Taiwan, Borneo and polar Canada, we further tested for the possible association of the FUS2 SNP with this form of endemic cancer. Our analysis, albeit limited, suggests no likely association between NPC and the FUS2 gene polymorphism. Further large-scale case-control studies are necessary and warranted to prove the strength of this contention. © 2003 Elsevier Ltd. All rights reserved. link_to_subscribed_fulltext Article in Journal/Newspaper inuit University of Hong Kong: HKU Scholars Hub Canada Molecular and Cellular Probes 18 1 39 44 |
institution |
Open Polar |
collection |
University of Hong Kong: HKU Scholars Hub |
op_collection_id |
ftunivhongkonghu |
language |
English |
topic |
Acetyltransferases - Genetics - Physiology Asia - Epidemiology - Ethnology Chromosomes Human Pair 3 Endemic Diseases Gene Frequency Genes Tumor Suppressor Humans Nasopharyngeal Neoplasms - Ethnology - Genetics Polymorphism Single Nucleotide Prevalence Protein Structure Tertiary |
spellingShingle |
Acetyltransferases - Genetics - Physiology Asia - Epidemiology - Ethnology Chromosomes Human Pair 3 Endemic Diseases Gene Frequency Genes Tumor Suppressor Humans Nasopharyngeal Neoplasms - Ethnology - Genetics Polymorphism Single Nucleotide Prevalence Protein Structure Tertiary Qian, CN Lerman, MI Tean Teh, B Godbole, S Zabarovsky, ER Kashuba, V Hu, LF Voevoda, M Dean, M Stanbridge, E Guo, X Li Lung, M Moody, M Fivash, M Duh, FM Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: Prevalence in Asian populations and analysis of association with nasopharyngeal cancer |
topic_facet |
Acetyltransferases - Genetics - Physiology Asia - Epidemiology - Ethnology Chromosomes Human Pair 3 Endemic Diseases Gene Frequency Genes Tumor Suppressor Humans Nasopharyngeal Neoplasms - Ethnology - Genetics Polymorphism Single Nucleotide Prevalence Protein Structure Tertiary |
description |
The FUS2 gene, encoding a novel cytoplasmic acetyltransferase, resides in the tumor suppressor gene region on human chromosome 3p21.3 and is considered a promising candidate tumor suppressor gene. We have identified a new single nucleotide polymorphism (SNP), c767A/T, in the coding region of the gene. The polymorphism leads to a non-conservative amino acid change (R222W) located between the acetyltransferase (GNAT) and the proline-rich domains of the protein. We have analyzed 254 subjects included in 14 sub-populations. The occurrence of the SNP varies with the ethnicity of the population, suggesting that this SNP could be a valuable biomarker for population genetics. It is most prevalent in various Asian populations (T allele frequency>0.54), followed by the Canadian polar Inuit (T allele frequency=0.3), African American (T allele frequency=0.17), and Caucasian population (T allele frequency=0.1). Since nasopharyngeal carcinoma (NPC) is frequent in Southern China, Taiwan, Borneo and polar Canada, we further tested for the possible association of the FUS2 SNP with this form of endemic cancer. Our analysis, albeit limited, suggests no likely association between NPC and the FUS2 gene polymorphism. Further large-scale case-control studies are necessary and warranted to prove the strength of this contention. © 2003 Elsevier Ltd. All rights reserved. link_to_subscribed_fulltext |
format |
Article in Journal/Newspaper |
author |
Qian, CN Lerman, MI Tean Teh, B Godbole, S Zabarovsky, ER Kashuba, V Hu, LF Voevoda, M Dean, M Stanbridge, E Guo, X Li Lung, M Moody, M Fivash, M Duh, FM |
author_facet |
Qian, CN Lerman, MI Tean Teh, B Godbole, S Zabarovsky, ER Kashuba, V Hu, LF Voevoda, M Dean, M Stanbridge, E Guo, X Li Lung, M Moody, M Fivash, M Duh, FM |
author_sort |
Qian, CN |
title |
Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: Prevalence in Asian populations and analysis of association with nasopharyngeal cancer |
title_short |
Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: Prevalence in Asian populations and analysis of association with nasopharyngeal cancer |
title_full |
Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: Prevalence in Asian populations and analysis of association with nasopharyngeal cancer |
title_fullStr |
Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: Prevalence in Asian populations and analysis of association with nasopharyngeal cancer |
title_full_unstemmed |
Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: Prevalence in Asian populations and analysis of association with nasopharyngeal cancer |
title_sort |
characterization of a new snp c767a/t (arg222trp) in the candidate tsg fus2 on human chromosome 3p21.3: prevalence in asian populations and analysis of association with nasopharyngeal cancer |
publisher |
Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymcpr |
publishDate |
2004 |
url |
https://doi.org/10.1016/j.mcp.2003.09.002 http://hdl.handle.net/10722/150788 |
geographic |
Canada |
geographic_facet |
Canada |
genre |
inuit |
genre_facet |
inuit |
op_relation |
Molecular and Cellular Probes http://www.scopus.com/mlt/select.url?eid=2-s2.0-10744221645&selection=ref&src=s&origin=recordpage Molecular And Cellular Probes, 2004, v. 18 n. 1, p. 39-44 doi:10.1016/j.mcp.2003.09.002 44 WOS:000220161300005 0890-8508 1 15036368 eid_2-s2.0-10744221645 39 http://hdl.handle.net/10722/150788 18 |
op_doi |
https://doi.org/10.1016/j.mcp.2003.09.002 |
container_title |
Molecular and Cellular Probes |
container_volume |
18 |
container_issue |
1 |
container_start_page |
39 |
op_container_end_page |
44 |
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1766046230534684672 |