A secondary sialic acid binding site on influenza virus neuraminidase: fact or fiction?

• Published in: Angewandte Chemie International Edition
• Main Authors: Haselhorst, T, Lai, JCC, Garcia, JM, Dyason, JC, Böhm, R, Madge, PD, Rose, FJ, von Itzstein, M, Peiris, JSM, Nicholls, JM
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home 2012
• Subjects: Neuraminidase - chemistry - metabolism; Nuclear Magnetic Resonance; Biomolecular; Orthomyxoviridae - chemistry - enzymology; Oseltamivir - pharmacology; N-Acetylneuraminic Acid - metabolism; Avian flu
• Online Access: https://doi.org/10.1002/anie.201108245; http://hdl.handle.net/10722/148687

One flu over the cuckoo's nest: The biological significance of a secondary sialic acid binding site on influenza virus neuraminidase remains elusive. On blocking the active site influenza-virus-containing virus-like particles with oseltamivir carboxylate, binding to α(2,3)-sialyllactose is still detected. Thus the sialyllactose must bind at a secondary sialic acid binding site (see structures: docking study of α(2,3)-sialyllactose in the secondary binding site of avian flu neuraminidase). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. link_to_subscribed_fulltext