A secondary sialic acid binding site on influenza virus neuraminidase: fact or fiction?
One flu over the cuckoo's nest: The biological significance of a secondary sialic acid binding site on influenza virus neuraminidase remains elusive. On blocking the active site influenza-virus-containing virus-like particles with oseltamivir carboxylate, binding to α(2,3)-sialyllactose is stil...
Published in: | Angewandte Chemie International Edition |
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Main Authors: | , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
2012
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Subjects: | |
Online Access: | https://doi.org/10.1002/anie.201108245 http://hdl.handle.net/10722/148687 |
Summary: | One flu over the cuckoo's nest: The biological significance of a secondary sialic acid binding site on influenza virus neuraminidase remains elusive. On blocking the active site influenza-virus-containing virus-like particles with oseltamivir carboxylate, binding to α(2,3)-sialyllactose is still detected. Thus the sialyllactose must bind at a secondary sialic acid binding site (see structures: docking study of α(2,3)-sialyllactose in the secondary binding site of avian flu neuraminidase). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. link_to_subscribed_fulltext |
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