Trends in lung cancer survival in the Nordic countries 1990–2016 : The NORDCAN survival studies
Objectives: The aim of this study was to evaluate if the previously reported improvements in lung cancer survival were consistent across age at diagnosis and by lung cancer subtypes. Materials and methods: Data on lung cancers diagnosed between 1990 and 2016 in Denmark, Finland, Iceland, Norway and...
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/576611 2024-06-23T07:54:06+00:00 Trends in lung cancer survival in the Nordic countries 1990–2016 : The NORDCAN survival studies Lundberg, Frida E. Ekman, Simon Johansson, Anna L.V. Engholm, Gerda Birgisson, Helgi Ólafsdóttir, Elínborg J. Mørch, Lina Steinrud Johannesen, Tom Børge Andersson, Therese M.L. Pettersson, David Seppä, Karri Virtanen, Anni Lambe, Mats Lambert, Paul C. HUSLAB Department of Pathology HUS Diagnostic Center 2024-06-06T04:54:04Z 8 application/pdf http://hdl.handle.net/10138/576611 eng eng ELSEVIER IRELAND LTD 10.1016/j.lungcan.2024.107826 This work was supported by the Swedish Cancer Society (Cancerfonden) under Grants CF 21\u20131890 (PCL) and CAN 2018/749 (ML) and the Swedish Research Council (Vetenskapsr\u00E5det) under Grants 2017\u201301591 (PCL) and 2021\u20131875 (PCL). The study funders had no role in study design; collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. Lundberg , F E , Ekman , S , Johansson , A L V , Engholm , G , Birgisson , H , Ólafsdóttir , E J , Mørch , L S , Johannesen , T B , Andersson , T M L , Pettersson , D , Seppä , K , Virtanen , A , Lambe , M & Lambert , P C 2024 , ' Trends in lung cancer survival in the Nordic countries 1990–2016 : The NORDCAN survival studies ' , Lung Cancer , vol. 192 , 107826 . https://doi.org/10.1016/j.lungcan.2024.107826 ORCID: /0000-0002-7467-8434/work/161251571 http://hdl.handle.net/10138/576611 61306f91-995d-42c2-a9d9-0dc9723f1d97 85193992911 cc_by info:eu-repo/semantics/openAccess openAccess Adenocarcinoma of Lung Age at diagnosis Cancer registries Carcinoma Non-Small-Cell Lung Epidemiology Lung neoplasms Neoplasm Staging Small Cell Lung Carcinoma Cancers Article publishedVersion 2024 ftunivhelsihelda 2024-06-11T14:22:15Z Objectives: The aim of this study was to evaluate if the previously reported improvements in lung cancer survival were consistent across age at diagnosis and by lung cancer subtypes. Materials and methods: Data on lung cancers diagnosed between 1990 and 2016 in Denmark, Finland, Iceland, Norway and Sweden were obtained from the NORDCAN database. Flexible parametric models were used to estimate age-standardized and age-specific relative survival by sex, as well as reference-adjusted crude probabilities of death and life-years lost. Age-standardised survival was also estimated by the three major subtypes; adenocarcincoma, squamous cell and small-cell carcinoma. Results: Both 1- and 5-year relative survival improved continuously in all countries. The pattern of improvement was similar across age groups and by subtype. The largest improvements in survival were seen in Denmark, while improvements were comparatively smaller in Finland. In the most recent period, age-standardised estimates of 5-year relative survival ranged from 13% to 26% and the 5-year crude probability of death due to lung cancer ranged from 73% to 85%. Across all Nordic countries, survival decreased with age, and was lower in men and for small-cell carcinoma. Conclusion: Lung cancer survival has improved substantially since 1990, in both women and men and across age. The improvements were seen in all major subtypes. However, lung cancer survival remains poor, with three out of four patients dying from their lung cancer within five years of diagnosis. Peer reviewed Article in Journal/Newspaper Iceland HELDA – University of Helsinki Open Repository Norway |
institution |
Open Polar |
collection |
HELDA – University of Helsinki Open Repository |
op_collection_id |
ftunivhelsihelda |
language |
English |
topic |
Adenocarcinoma of Lung Age at diagnosis Cancer registries Carcinoma Non-Small-Cell Lung Epidemiology Lung neoplasms Neoplasm Staging Small Cell Lung Carcinoma Cancers |
spellingShingle |
Adenocarcinoma of Lung Age at diagnosis Cancer registries Carcinoma Non-Small-Cell Lung Epidemiology Lung neoplasms Neoplasm Staging Small Cell Lung Carcinoma Cancers Lundberg, Frida E. Ekman, Simon Johansson, Anna L.V. Engholm, Gerda Birgisson, Helgi Ólafsdóttir, Elínborg J. Mørch, Lina Steinrud Johannesen, Tom Børge Andersson, Therese M.L. Pettersson, David Seppä, Karri Virtanen, Anni Lambe, Mats Lambert, Paul C. Trends in lung cancer survival in the Nordic countries 1990–2016 : The NORDCAN survival studies |
topic_facet |
Adenocarcinoma of Lung Age at diagnosis Cancer registries Carcinoma Non-Small-Cell Lung Epidemiology Lung neoplasms Neoplasm Staging Small Cell Lung Carcinoma Cancers |
description |
Objectives: The aim of this study was to evaluate if the previously reported improvements in lung cancer survival were consistent across age at diagnosis and by lung cancer subtypes. Materials and methods: Data on lung cancers diagnosed between 1990 and 2016 in Denmark, Finland, Iceland, Norway and Sweden were obtained from the NORDCAN database. Flexible parametric models were used to estimate age-standardized and age-specific relative survival by sex, as well as reference-adjusted crude probabilities of death and life-years lost. Age-standardised survival was also estimated by the three major subtypes; adenocarcincoma, squamous cell and small-cell carcinoma. Results: Both 1- and 5-year relative survival improved continuously in all countries. The pattern of improvement was similar across age groups and by subtype. The largest improvements in survival were seen in Denmark, while improvements were comparatively smaller in Finland. In the most recent period, age-standardised estimates of 5-year relative survival ranged from 13% to 26% and the 5-year crude probability of death due to lung cancer ranged from 73% to 85%. Across all Nordic countries, survival decreased with age, and was lower in men and for small-cell carcinoma. Conclusion: Lung cancer survival has improved substantially since 1990, in both women and men and across age. The improvements were seen in all major subtypes. However, lung cancer survival remains poor, with three out of four patients dying from their lung cancer within five years of diagnosis. Peer reviewed |
author2 |
HUSLAB Department of Pathology HUS Diagnostic Center |
format |
Article in Journal/Newspaper |
author |
Lundberg, Frida E. Ekman, Simon Johansson, Anna L.V. Engholm, Gerda Birgisson, Helgi Ólafsdóttir, Elínborg J. Mørch, Lina Steinrud Johannesen, Tom Børge Andersson, Therese M.L. Pettersson, David Seppä, Karri Virtanen, Anni Lambe, Mats Lambert, Paul C. |
author_facet |
Lundberg, Frida E. Ekman, Simon Johansson, Anna L.V. Engholm, Gerda Birgisson, Helgi Ólafsdóttir, Elínborg J. Mørch, Lina Steinrud Johannesen, Tom Børge Andersson, Therese M.L. Pettersson, David Seppä, Karri Virtanen, Anni Lambe, Mats Lambert, Paul C. |
author_sort |
Lundberg, Frida E. |
title |
Trends in lung cancer survival in the Nordic countries 1990–2016 : The NORDCAN survival studies |
title_short |
Trends in lung cancer survival in the Nordic countries 1990–2016 : The NORDCAN survival studies |
title_full |
Trends in lung cancer survival in the Nordic countries 1990–2016 : The NORDCAN survival studies |
title_fullStr |
Trends in lung cancer survival in the Nordic countries 1990–2016 : The NORDCAN survival studies |
title_full_unstemmed |
Trends in lung cancer survival in the Nordic countries 1990–2016 : The NORDCAN survival studies |
title_sort |
trends in lung cancer survival in the nordic countries 1990–2016 : the nordcan survival studies |
publisher |
ELSEVIER IRELAND LTD |
publishDate |
2024 |
url |
http://hdl.handle.net/10138/576611 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
10.1016/j.lungcan.2024.107826 This work was supported by the Swedish Cancer Society (Cancerfonden) under Grants CF 21\u20131890 (PCL) and CAN 2018/749 (ML) and the Swedish Research Council (Vetenskapsr\u00E5det) under Grants 2017\u201301591 (PCL) and 2021\u20131875 (PCL). The study funders had no role in study design; collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. Lundberg , F E , Ekman , S , Johansson , A L V , Engholm , G , Birgisson , H , Ólafsdóttir , E J , Mørch , L S , Johannesen , T B , Andersson , T M L , Pettersson , D , Seppä , K , Virtanen , A , Lambe , M & Lambert , P C 2024 , ' Trends in lung cancer survival in the Nordic countries 1990–2016 : The NORDCAN survival studies ' , Lung Cancer , vol. 192 , 107826 . https://doi.org/10.1016/j.lungcan.2024.107826 ORCID: /0000-0002-7467-8434/work/161251571 http://hdl.handle.net/10138/576611 61306f91-995d-42c2-a9d9-0dc9723f1d97 85193992911 |
op_rights |
cc_by info:eu-repo/semantics/openAccess openAccess |
_version_ |
1802646073646252032 |