Genetic liability to psychiatric disorders in early childhood : phenotypic effects and differing sensitivity to environmental influences
The large genome-wide association studies conducted during the past fifteen years have broadly increased our understanding of the genetic basis of psychiatric disorders. These studies have shown that not only are all psychiatric disorders highly polygenic, but the implicated genetic factors are larg...
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Helsingin yliopisto
2024
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/575356 2024-06-09T07:48:33+00:00 Genetic liability to psychiatric disorders in early childhood : phenotypic effects and differing sensitivity to environmental influences Liuhanen, Johanna Helsingin yliopisto, lääketieteellinen tiedekunta Helsingfors universitet, medicinska fakulteten University of Helsinki, Faculty of Medicine Finnish Institute for Health and Welfare Musliner, Katherine Paunio, Tiina Suvisaari, Jaana 2024-05-13T13:01:19Z application/pdf fulltext http://hdl.handle.net/10138/575356 eng eng Helsingin yliopisto Helsingfors universitet University of Helsinki Dissertationes Universitatis Helsingiensis 978-951-51-9856-3 2954-2898 2954-2952 146 978-951-51-9855-6 http://hdl.handle.net/10138/575356 URN:ISBN:978-951-51-9855-6 Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty. This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited. Publikationen är skyddad av upphovsrätten. Den får läsas och skrivas ut för personligt bruk. Användning i kommersiellt syfte är förbjuden. 3124 Neurologia ja psykiatria 3124 Neurologi och psykiatri 3124 Neurology and psychiatry psykiatrinen genetiikka Doctoral Programme in Integrative Life Science Integroivien biotieteiden tohtoriohjelma Doktorandprogrammet i integrerande biovetenskap Artikkeliväitöskirja Doctoral dissertation (article-based) Artikelavhandling G5 Artikkeliväitöskirja doctoralThesis 2024 ftunivhelsihelda 2024-05-14T23:40:59Z The large genome-wide association studies conducted during the past fifteen years have broadly increased our understanding of the genetic basis of psychiatric disorders. These studies have shown that not only are all psychiatric disorders highly polygenic, but the implicated genetic factors are largely common variation that all of us carry. This raises the question of whether the common genetic liability is also manifested in the unaffected general population, and, whether they have detectable effects, or phenotypic effects, already in childhood, suggesting genetically influenced psychopathological developmental pathways. Furthermore, the genetic factors may have indirect effects by affecting the sensitivity to the environment. Studying these effects may increase our understanding of genetically influenced developmental pathways to mental health problems, which is essential in considering preventive measures and interventions. The main aim of this thesis was to examine the effect of genetic liability for psychiatric disorders on childhood development and on the sensitivity to environmental influences in the first two years of life. The focus was on the genetic liability for two phenotypes: schizophrenia, a severe mental disorder profoundly affecting the function of neuronal networks and typically manifesting with cognitive impairments, and neuroticism, a trait associated with problems in emotion regulation and general susceptibility to mental health problems. The childhood phenotypes covered a wide range of indicators, from markers of neurophysiological maturation to motor as well as socio-emotional development. The study utilized three Finnish birth cohorts, the Northern Finland Birth Cohort 1966 (Study I), CHILD-SLEEP (Studies II and III), and FinnBrain (Study III). Additionally, a Finnish schizophrenia family sample was used as a replication sample (Study I). Polysomnography recordings analyzed in Study II were available for a subsample (N = 92) of the CHILD-SLEEP birth cohort. Motor development (Study II) ... Doctoral or Postdoctoral Thesis Northern Finland HELDA – University of Helsinki Open Repository |
institution |
Open Polar |
collection |
HELDA – University of Helsinki Open Repository |
op_collection_id |
ftunivhelsihelda |
language |
English |
topic |
3124 Neurologia ja psykiatria 3124 Neurologi och psykiatri 3124 Neurology and psychiatry psykiatrinen genetiikka Doctoral Programme in Integrative Life Science Integroivien biotieteiden tohtoriohjelma Doktorandprogrammet i integrerande biovetenskap |
spellingShingle |
3124 Neurologia ja psykiatria 3124 Neurologi och psykiatri 3124 Neurology and psychiatry psykiatrinen genetiikka Doctoral Programme in Integrative Life Science Integroivien biotieteiden tohtoriohjelma Doktorandprogrammet i integrerande biovetenskap Liuhanen, Johanna Genetic liability to psychiatric disorders in early childhood : phenotypic effects and differing sensitivity to environmental influences |
topic_facet |
3124 Neurologia ja psykiatria 3124 Neurologi och psykiatri 3124 Neurology and psychiatry psykiatrinen genetiikka Doctoral Programme in Integrative Life Science Integroivien biotieteiden tohtoriohjelma Doktorandprogrammet i integrerande biovetenskap |
description |
The large genome-wide association studies conducted during the past fifteen years have broadly increased our understanding of the genetic basis of psychiatric disorders. These studies have shown that not only are all psychiatric disorders highly polygenic, but the implicated genetic factors are largely common variation that all of us carry. This raises the question of whether the common genetic liability is also manifested in the unaffected general population, and, whether they have detectable effects, or phenotypic effects, already in childhood, suggesting genetically influenced psychopathological developmental pathways. Furthermore, the genetic factors may have indirect effects by affecting the sensitivity to the environment. Studying these effects may increase our understanding of genetically influenced developmental pathways to mental health problems, which is essential in considering preventive measures and interventions. The main aim of this thesis was to examine the effect of genetic liability for psychiatric disorders on childhood development and on the sensitivity to environmental influences in the first two years of life. The focus was on the genetic liability for two phenotypes: schizophrenia, a severe mental disorder profoundly affecting the function of neuronal networks and typically manifesting with cognitive impairments, and neuroticism, a trait associated with problems in emotion regulation and general susceptibility to mental health problems. The childhood phenotypes covered a wide range of indicators, from markers of neurophysiological maturation to motor as well as socio-emotional development. The study utilized three Finnish birth cohorts, the Northern Finland Birth Cohort 1966 (Study I), CHILD-SLEEP (Studies II and III), and FinnBrain (Study III). Additionally, a Finnish schizophrenia family sample was used as a replication sample (Study I). Polysomnography recordings analyzed in Study II were available for a subsample (N = 92) of the CHILD-SLEEP birth cohort. Motor development (Study II) ... |
author2 |
Helsingin yliopisto, lääketieteellinen tiedekunta Helsingfors universitet, medicinska fakulteten University of Helsinki, Faculty of Medicine Finnish Institute for Health and Welfare Musliner, Katherine Paunio, Tiina Suvisaari, Jaana |
format |
Doctoral or Postdoctoral Thesis |
author |
Liuhanen, Johanna |
author_facet |
Liuhanen, Johanna |
author_sort |
Liuhanen, Johanna |
title |
Genetic liability to psychiatric disorders in early childhood : phenotypic effects and differing sensitivity to environmental influences |
title_short |
Genetic liability to psychiatric disorders in early childhood : phenotypic effects and differing sensitivity to environmental influences |
title_full |
Genetic liability to psychiatric disorders in early childhood : phenotypic effects and differing sensitivity to environmental influences |
title_fullStr |
Genetic liability to psychiatric disorders in early childhood : phenotypic effects and differing sensitivity to environmental influences |
title_full_unstemmed |
Genetic liability to psychiatric disorders in early childhood : phenotypic effects and differing sensitivity to environmental influences |
title_sort |
genetic liability to psychiatric disorders in early childhood : phenotypic effects and differing sensitivity to environmental influences |
publisher |
Helsingin yliopisto |
publishDate |
2024 |
url |
http://hdl.handle.net/10138/575356 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
Dissertationes Universitatis Helsingiensis 978-951-51-9856-3 2954-2898 2954-2952 146 978-951-51-9855-6 http://hdl.handle.net/10138/575356 URN:ISBN:978-951-51-9855-6 |
op_rights |
Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty. This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited. Publikationen är skyddad av upphovsrätten. Den får läsas och skrivas ut för personligt bruk. Användning i kommersiellt syfte är förbjuden. |
_version_ |
1801380311204888576 |