The interplay between inflammatory cytokines and cardiometabolic disease : bi-directional mendelian randomisation study
Objective To leverage large scale genetic association data to investigate the interplay between circulating cytokines and cardiometabolic traits, and thus identifying potential therapeutic targets. Design Bi-directional Mendelian randomisation study. Setting Genome-wide association studies from thre...
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Language: | English |
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BMJ PUBLISHING GROUP
2024
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Online Access: | http://hdl.handle.net/10138/573602 |
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HELDA – University of Helsinki Open Repository |
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English |
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Cardiology Epidemiology Genetics 3121 General medicine internal medicine and other clinical medicine 1184 Genetics developmental biology physiology |
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Cardiology Epidemiology Genetics 3121 General medicine internal medicine and other clinical medicine 1184 Genetics developmental biology physiology Karhunen, Ville Gill, Dipender Huang, Jian Bouras, Emmanouil Malik, Rainer Ponsford, Mark J. Ahola-Olli, Ari Papadopoulou, Areti Palaniswamy, Saranya Sebert, Sylvain Wielscher, Matthias Auvinen, Juha Veijola, Juha Herzig, Karl-Heinz Timonen, Markku Keinaenen-Kiukaanniemi, Sirkka Dichgans, Martin Salmi, Marko Jalkanen, Sirpa Lehtimaeki, Terho Salomaa, Veikko Raitakari, Olli Jones, Simon A. Hovingh, G. Kees Tsilidis, Konstantinos K. Jaervelin, Marjo-Riitta Dehghan, Abbas The interplay between inflammatory cytokines and cardiometabolic disease : bi-directional mendelian randomisation study |
topic_facet |
Cardiology Epidemiology Genetics 3121 General medicine internal medicine and other clinical medicine 1184 Genetics developmental biology physiology |
description |
Objective To leverage large scale genetic association data to investigate the interplay between circulating cytokines and cardiometabolic traits, and thus identifying potential therapeutic targets. Design Bi-directional Mendelian randomisation study. Setting Genome-wide association studies from three Finnish cohorts (Northern Finland Birth Cohort 1966, Young Finns Study, or FINRISK study), and genetic association summary statistics pooled from observational studies for expression quantitative trait loci and cardiometabolic traits. Participants Data for 47 circulating cytokines in 13 365 individuals from genome-wide association studies, summary statistic data for up to 21 735 individuals on circulating cytokines, summary statistic gene expression data across 49 tissues in 838 individuals, and summary statistic data for up to 1 320 016 individuals on cardiometabolic traits. Interventions Relations between circulating cytokines and cardiovascular, anthropometric, lipid, or glycaemic traits (coronary artery disease, stroke, type 2 diabetes mellitus, body mass index, waist circumference, waist to hip ratio, systolic blood pressure, glycated haemoglobin, high density lipoprotein cholesterol, low density lipoprotein cholesterol, total cholesterol, triglycerides, C reactive protein, glucose, fasting insulin, and lifetime smoking). Main outcome methods Genetic instrumental variables that are biologically plausible for the circulating cytokines were generated. The effects of cardiometabolic risk factors on concentrations of circulating cytokines, circulating cytokines on other circulating cytokines, and circulating cytokines on cardiometabolic outcomes were investigated. Results Genetic evidence (mendelian randomisation P<0.0011) suggests that higher body mass index, waist circumference, smoking, higher concentrations of lipids, and systolic blood pressure increase circulating concentrations of several inflammatory cytokines and C reactive protein. Evidence for causal relations (mendelian randomisation P<0.0011) ... |
author2 |
Genomics of Neurological and Neuropsychiatric Disorders Institute for Molecular Medicine Finland |
format |
Article in Journal/Newspaper |
author |
Karhunen, Ville Gill, Dipender Huang, Jian Bouras, Emmanouil Malik, Rainer Ponsford, Mark J. Ahola-Olli, Ari Papadopoulou, Areti Palaniswamy, Saranya Sebert, Sylvain Wielscher, Matthias Auvinen, Juha Veijola, Juha Herzig, Karl-Heinz Timonen, Markku Keinaenen-Kiukaanniemi, Sirkka Dichgans, Martin Salmi, Marko Jalkanen, Sirpa Lehtimaeki, Terho Salomaa, Veikko Raitakari, Olli Jones, Simon A. Hovingh, G. Kees Tsilidis, Konstantinos K. Jaervelin, Marjo-Riitta Dehghan, Abbas |
author_facet |
Karhunen, Ville Gill, Dipender Huang, Jian Bouras, Emmanouil Malik, Rainer Ponsford, Mark J. Ahola-Olli, Ari Papadopoulou, Areti Palaniswamy, Saranya Sebert, Sylvain Wielscher, Matthias Auvinen, Juha Veijola, Juha Herzig, Karl-Heinz Timonen, Markku Keinaenen-Kiukaanniemi, Sirkka Dichgans, Martin Salmi, Marko Jalkanen, Sirpa Lehtimaeki, Terho Salomaa, Veikko Raitakari, Olli Jones, Simon A. Hovingh, G. Kees Tsilidis, Konstantinos K. Jaervelin, Marjo-Riitta Dehghan, Abbas |
author_sort |
Karhunen, Ville |
title |
The interplay between inflammatory cytokines and cardiometabolic disease : bi-directional mendelian randomisation study |
title_short |
The interplay between inflammatory cytokines and cardiometabolic disease : bi-directional mendelian randomisation study |
title_full |
The interplay between inflammatory cytokines and cardiometabolic disease : bi-directional mendelian randomisation study |
title_fullStr |
The interplay between inflammatory cytokines and cardiometabolic disease : bi-directional mendelian randomisation study |
title_full_unstemmed |
The interplay between inflammatory cytokines and cardiometabolic disease : bi-directional mendelian randomisation study |
title_sort |
interplay between inflammatory cytokines and cardiometabolic disease : bi-directional mendelian randomisation study |
publisher |
BMJ PUBLISHING GROUP |
publishDate |
2024 |
url |
http://hdl.handle.net/10138/573602 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
10.1136/bmjmed-2022-000157 We thank all cohort members and researchers who participated in the 31-year study of the Northern Finland Birth Cohort 1966. We also wish to acknowledge the work of the Northern Finland Birth Cohort project centre. The authors acknowledge the contributors of the data used in this work: CARDIoGRAMplusC4D, CHARGE, DIAGRAM, GIANT, GLGC, MAGIC, MEGASTROKE, and UK Biobank. Karhunen , V , Gill , D , Huang , J , Bouras , E , Malik , R , Ponsford , M J , Ahola-Olli , A , Papadopoulou , A , Palaniswamy , S , Sebert , S , Wielscher , M , Auvinen , J , Veijola , J , Herzig , K-H , Timonen , M , Keinaenen-Kiukaanniemi , S , Dichgans , M , Salmi , M , Jalkanen , S , Lehtimaeki , T , Salomaa , V , Raitakari , O , Jones , S A , Hovingh , G K , Tsilidis , K K , Jaervelin , M-R & Dehghan , A 2023 , ' The interplay between inflammatory cytokines and cardiometabolic disease : bi-directional mendelian randomisation study ' , BMJ MEDICINE , vol. 2 , no. 1 , e000157 . https://doi.org/10.1136/bmjmed-2022-000157 http://hdl.handle.net/10138/573602 36550082-82bb-4427-8a0d-72944ecd535f 36936266 001150782000025 |
op_rights |
cc_by info:eu-repo/semantics/openAccess openAccess |
_version_ |
1796948907807211520 |
spelling |
ftunivhelsihelda:oai:helda.helsinki.fi:10138/573602 2024-04-21T08:08:32+00:00 The interplay between inflammatory cytokines and cardiometabolic disease : bi-directional mendelian randomisation study Karhunen, Ville Gill, Dipender Huang, Jian Bouras, Emmanouil Malik, Rainer Ponsford, Mark J. Ahola-Olli, Ari Papadopoulou, Areti Palaniswamy, Saranya Sebert, Sylvain Wielscher, Matthias Auvinen, Juha Veijola, Juha Herzig, Karl-Heinz Timonen, Markku Keinaenen-Kiukaanniemi, Sirkka Dichgans, Martin Salmi, Marko Jalkanen, Sirpa Lehtimaeki, Terho Salomaa, Veikko Raitakari, Olli Jones, Simon A. Hovingh, G. Kees Tsilidis, Konstantinos K. Jaervelin, Marjo-Riitta Dehghan, Abbas Genomics of Neurological and Neuropsychiatric Disorders Institute for Molecular Medicine Finland 2024-03-25T11:01:04Z 9 application/pdf http://hdl.handle.net/10138/573602 eng eng BMJ PUBLISHING GROUP 10.1136/bmjmed-2022-000157 We thank all cohort members and researchers who participated in the 31-year study of the Northern Finland Birth Cohort 1966. We also wish to acknowledge the work of the Northern Finland Birth Cohort project centre. The authors acknowledge the contributors of the data used in this work: CARDIoGRAMplusC4D, CHARGE, DIAGRAM, GIANT, GLGC, MAGIC, MEGASTROKE, and UK Biobank. Karhunen , V , Gill , D , Huang , J , Bouras , E , Malik , R , Ponsford , M J , Ahola-Olli , A , Papadopoulou , A , Palaniswamy , S , Sebert , S , Wielscher , M , Auvinen , J , Veijola , J , Herzig , K-H , Timonen , M , Keinaenen-Kiukaanniemi , S , Dichgans , M , Salmi , M , Jalkanen , S , Lehtimaeki , T , Salomaa , V , Raitakari , O , Jones , S A , Hovingh , G K , Tsilidis , K K , Jaervelin , M-R & Dehghan , A 2023 , ' The interplay between inflammatory cytokines and cardiometabolic disease : bi-directional mendelian randomisation study ' , BMJ MEDICINE , vol. 2 , no. 1 , e000157 . https://doi.org/10.1136/bmjmed-2022-000157 http://hdl.handle.net/10138/573602 36550082-82bb-4427-8a0d-72944ecd535f 36936266 001150782000025 cc_by info:eu-repo/semantics/openAccess openAccess Cardiology Epidemiology Genetics 3121 General medicine internal medicine and other clinical medicine 1184 Genetics developmental biology physiology Article publishedVersion 2024 ftunivhelsihelda 2024-03-27T17:50:30Z Objective To leverage large scale genetic association data to investigate the interplay between circulating cytokines and cardiometabolic traits, and thus identifying potential therapeutic targets. Design Bi-directional Mendelian randomisation study. Setting Genome-wide association studies from three Finnish cohorts (Northern Finland Birth Cohort 1966, Young Finns Study, or FINRISK study), and genetic association summary statistics pooled from observational studies for expression quantitative trait loci and cardiometabolic traits. Participants Data for 47 circulating cytokines in 13 365 individuals from genome-wide association studies, summary statistic data for up to 21 735 individuals on circulating cytokines, summary statistic gene expression data across 49 tissues in 838 individuals, and summary statistic data for up to 1 320 016 individuals on cardiometabolic traits. Interventions Relations between circulating cytokines and cardiovascular, anthropometric, lipid, or glycaemic traits (coronary artery disease, stroke, type 2 diabetes mellitus, body mass index, waist circumference, waist to hip ratio, systolic blood pressure, glycated haemoglobin, high density lipoprotein cholesterol, low density lipoprotein cholesterol, total cholesterol, triglycerides, C reactive protein, glucose, fasting insulin, and lifetime smoking). Main outcome methods Genetic instrumental variables that are biologically plausible for the circulating cytokines were generated. The effects of cardiometabolic risk factors on concentrations of circulating cytokines, circulating cytokines on other circulating cytokines, and circulating cytokines on cardiometabolic outcomes were investigated. Results Genetic evidence (mendelian randomisation P<0.0011) suggests that higher body mass index, waist circumference, smoking, higher concentrations of lipids, and systolic blood pressure increase circulating concentrations of several inflammatory cytokines and C reactive protein. Evidence for causal relations (mendelian randomisation P<0.0011) ... Article in Journal/Newspaper Northern Finland HELDA – University of Helsinki Open Repository |