Early chronic airway disease in young and middle-aged smokers
Chronic obstructive pulmonary disease (COPD) is an under-diagnosed and life-threatening progressive disease. Early symptoms of COPD include excessive sputum production and chronic cough. The primary risk factor of this disease in the western world is smoking. COPD is confirmed by spirometry, which d...
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/37632 2023-08-20T04:08:42+02:00 Early chronic airway disease in young and middle-aged smokers Varhainen hengitystiesairaus nuorilla ja keski-ikäisillä tupakanpolttajilla Toljamo, Tuula Altraja, Alan University of Helsinki, Faculty of Medicine, Institute of Clinical Medicine, Pulmonary Division, Helsinki University Central Hospital, Helsinki, Finland Lapland Central Hospital, Department of Medicine, Pulmonary Division, Rovaniemi, Finland Helsingin yliopisto, lääketieteellinen tiedekunta, kliininen laitos Helsingfors universitet, medicinska fakulteten, institutionen för klinisk medicin Kinnula, Vuokko Nieminen, Pentti 2012-11-26T09:46:50Z application/pdf http://hdl.handle.net/10138/37632 eng eng Helsingin yliopisto Helsingfors universitet University of Helsinki URN:ISBN:978-952-10-8454-6 Unigrafia: 2012 http://hdl.handle.net/10138/37632 Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty. This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited. Publikationen är skyddad av upphovsrätten. Den får läsas och skrivas ut för personligt bruk. Användning i kommersiellt syfte är förbjuden. lääketiede Text Doctoral dissertation (article-based) Artikkeliväitöskirja Artikelavhandling doctoralThesis 2012 ftunivhelsihelda 2023-07-28T06:06:11Z Chronic obstructive pulmonary disease (COPD) is an under-diagnosed and life-threatening progressive disease. Early symptoms of COPD include excessive sputum production and chronic cough. The primary risk factor of this disease in the western world is smoking. COPD is confirmed by spirometry, which does not totally reveal reversible airway obstruction. This study, conducted mainly in the Northern Finland, aimed to assess 1) smoking habits and smoking cessation in healthy middle-aged and young adults, 2) the prevalence of COPD and role of spirometry and prolonged respiratory symptoms in the diagnosis of COPD of smoking middle-aged adults, 3) the association of symptoms of chronic bronchitis with smoking habits in young adult males, and 4) to seek and to identify new potential biomarkers related to early COPD using non-hypothesis driven non-biased proteomics. A two-year prospective study included two visits to evaluate symptoms in healthy cigarette smokers, to screen new COPD cases and to assess the success of smoking cessation using motivational counselling and pharmacological therapies. In addition, a quantitative cross-sectional questionnaire survey was conducted in 1163 male conscripts during their military service in Northern Finland. A lung tissue proteomic approach was used to identify new COPD biomarkers. Spirometry revealed COPD by GOLD criteria in 11,0% and by national criteria in 15.3 % of originally asymptomatic chronic smokers. Further, chronic cough or sputum production was detected in 62.0% of the participants. After two years, 23.3% of adults had succeeded in quitting smoking. In young adults, 46.5% were daily smokers. The prevalence of self-reported chronic cough and sputum production was high in daily smokers (40.7%). The majority (60.2%) of the daily young smokers had made quit attempts and 46.9% of them had used nicotine replacement therapy (NRT). Based on the lung tissue proteomics, surfactant protein A (SP-A) was one of the most highly elevated spots in the COPD lung. The plasma SP-A ... Doctoral or Postdoctoral Thesis Northern Finland Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
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Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
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English |
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lääketiede Toljamo, Tuula Early chronic airway disease in young and middle-aged smokers |
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lääketiede |
description |
Chronic obstructive pulmonary disease (COPD) is an under-diagnosed and life-threatening progressive disease. Early symptoms of COPD include excessive sputum production and chronic cough. The primary risk factor of this disease in the western world is smoking. COPD is confirmed by spirometry, which does not totally reveal reversible airway obstruction. This study, conducted mainly in the Northern Finland, aimed to assess 1) smoking habits and smoking cessation in healthy middle-aged and young adults, 2) the prevalence of COPD and role of spirometry and prolonged respiratory symptoms in the diagnosis of COPD of smoking middle-aged adults, 3) the association of symptoms of chronic bronchitis with smoking habits in young adult males, and 4) to seek and to identify new potential biomarkers related to early COPD using non-hypothesis driven non-biased proteomics. A two-year prospective study included two visits to evaluate symptoms in healthy cigarette smokers, to screen new COPD cases and to assess the success of smoking cessation using motivational counselling and pharmacological therapies. In addition, a quantitative cross-sectional questionnaire survey was conducted in 1163 male conscripts during their military service in Northern Finland. A lung tissue proteomic approach was used to identify new COPD biomarkers. Spirometry revealed COPD by GOLD criteria in 11,0% and by national criteria in 15.3 % of originally asymptomatic chronic smokers. Further, chronic cough or sputum production was detected in 62.0% of the participants. After two years, 23.3% of adults had succeeded in quitting smoking. In young adults, 46.5% were daily smokers. The prevalence of self-reported chronic cough and sputum production was high in daily smokers (40.7%). The majority (60.2%) of the daily young smokers had made quit attempts and 46.9% of them had used nicotine replacement therapy (NRT). Based on the lung tissue proteomics, surfactant protein A (SP-A) was one of the most highly elevated spots in the COPD lung. The plasma SP-A ... |
author2 |
Altraja, Alan University of Helsinki, Faculty of Medicine, Institute of Clinical Medicine, Pulmonary Division, Helsinki University Central Hospital, Helsinki, Finland Lapland Central Hospital, Department of Medicine, Pulmonary Division, Rovaniemi, Finland Helsingin yliopisto, lääketieteellinen tiedekunta, kliininen laitos Helsingfors universitet, medicinska fakulteten, institutionen för klinisk medicin Kinnula, Vuokko Nieminen, Pentti |
format |
Doctoral or Postdoctoral Thesis |
author |
Toljamo, Tuula |
author_facet |
Toljamo, Tuula |
author_sort |
Toljamo, Tuula |
title |
Early chronic airway disease in young and middle-aged smokers |
title_short |
Early chronic airway disease in young and middle-aged smokers |
title_full |
Early chronic airway disease in young and middle-aged smokers |
title_fullStr |
Early chronic airway disease in young and middle-aged smokers |
title_full_unstemmed |
Early chronic airway disease in young and middle-aged smokers |
title_sort |
early chronic airway disease in young and middle-aged smokers |
publisher |
Helsingin yliopisto |
publishDate |
2012 |
url |
http://hdl.handle.net/10138/37632 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
URN:ISBN:978-952-10-8454-6 Unigrafia: 2012 http://hdl.handle.net/10138/37632 |
op_rights |
Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty. This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited. Publikationen är skyddad av upphovsrätten. Den får läsas och skrivas ut för personligt bruk. Användning i kommersiellt syfte är förbjuden. |
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1774721142089580544 |