Platelet function testing : Current practice among clinical centres in Northern Europe
Introduction Platelet function tests are used to screen and diagnose patients with possible inherited platelet function defects (IPFD). Some acquired platelet dysfunction may be caused by certain drugs or comorbidities, which need to be excluded before testing. Aims To identify current practice amon...
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/346639 2024-01-07T09:44:17+01:00 Platelet function testing : Current practice among clinical centres in Northern Europe Nordic Haemophilia Council Szanto, Timea Zetterberg, Eva Ramström, Sofia Kärkkäinen, Satu Lassila, Riitta Clinicum University of Helsinki HUS Comprehensive Cancer Center Hematologian yksikkö Research Program in Systems Oncology Department of Oncology 2022-08-03T09:57:01Z 7 application/pdf http://hdl.handle.net/10138/346639 eng eng Wiley 10.1111/hae.14578 We acknowledge all centres and their staff for their participation to this study. This article was funded by Helsinki University Hospital grant TYH2020318. Nordic Haemophilia Council , Szanto , T , Zetterberg , E , Ramström , S , Kärkkäinen , S & Lassila , R 2022 , ' Platelet function testing : Current practice among clinical centres in Northern Europe ' , Haemophilia , vol. 28 , no. 4 , pp. 642-648 . https://doi.org/10.1111/hae.14578 64bb51a7-bd6a-4fa1-8510-4131fd734dbf http://hdl.handle.net/10138/346639 000790857600001 cc_by_nc openAccess info:eu-repo/semantics/openAccess blood platelet disorders data collection platelet function testing platelets survey BLEEDING ASSESSMENT-TOOL DISORDERS DIAGNOSIS COMMUNICATION SUBCOMMITTEE AGGREGOMETRY SSC 3121 General medicine internal medicine and other clinical medicine Article publishedVersion 2022 ftunivhelsihelda 2023-12-14T00:06:35Z Introduction Platelet function tests are used to screen and diagnose patients with possible inherited platelet function defects (IPFD). Some acquired platelet dysfunction may be caused by certain drugs or comorbidities, which need to be excluded before testing. Aims To identify current practice among centres performing platelet function tests in Northern Europe. Methods A total of 14 clinical centres from Sweden (six), Finland (two), Denmark (two), Norway (one), Estonia (two) and Iceland (one) completed the survey questionnaire, the population capture area of about 29.5 million. Results Six of the 14 (42.8%) centres providing platelet function assessment represent comprehensive treatment centres (EUHANET status). A Bleeding score (BS) or ISTH bleeding assessment tool (ISTH BAT score) is evaluated in 11/14 (78.6%) centres and family history in all. Five/14 centres (35.7%) use structured preanalytical patient instructions, and 10/14 (71.4%) recorded questionnaire on the preassessment of avoidance of any drugs or natural products affecting platelet functions. Preliminary investigations of screening tests of coagulation are performed in 10/14 (71.4%), while in 4/14 (28.6%), the diagnostic work-up of IPFD and von Willebrand disease (VWD) is performed simultaneously. The work-up of IPFD includes peripheral blood smear in 10/14 (71.4%), platelet aggregometry in all, flow cytometry in 10/14 (71.4%) and Platelet Function Analysis (PFA) in 3/11 (28.6%). Molecular genetic diagnosis is available in 7/14 (50%) centres. Conclusions The considerable variability in the current practice illustrates the need for harmonization between the Northern European centres according to the international registers (i.e. EUHASS) and IPFD guidelines (ISTH, EHA). Peer reviewed Article in Journal/Newspaper Iceland HELDA – University of Helsinki Open Repository Norway Haemophilia 28 4 642 648 |
institution |
Open Polar |
collection |
HELDA – University of Helsinki Open Repository |
op_collection_id |
ftunivhelsihelda |
language |
English |
topic |
blood platelet disorders data collection platelet function testing platelets survey BLEEDING ASSESSMENT-TOOL DISORDERS DIAGNOSIS COMMUNICATION SUBCOMMITTEE AGGREGOMETRY SSC 3121 General medicine internal medicine and other clinical medicine |
spellingShingle |
blood platelet disorders data collection platelet function testing platelets survey BLEEDING ASSESSMENT-TOOL DISORDERS DIAGNOSIS COMMUNICATION SUBCOMMITTEE AGGREGOMETRY SSC 3121 General medicine internal medicine and other clinical medicine Nordic Haemophilia Council Szanto, Timea Zetterberg, Eva Ramström, Sofia Kärkkäinen, Satu Lassila, Riitta Platelet function testing : Current practice among clinical centres in Northern Europe |
topic_facet |
blood platelet disorders data collection platelet function testing platelets survey BLEEDING ASSESSMENT-TOOL DISORDERS DIAGNOSIS COMMUNICATION SUBCOMMITTEE AGGREGOMETRY SSC 3121 General medicine internal medicine and other clinical medicine |
description |
Introduction Platelet function tests are used to screen and diagnose patients with possible inherited platelet function defects (IPFD). Some acquired platelet dysfunction may be caused by certain drugs or comorbidities, which need to be excluded before testing. Aims To identify current practice among centres performing platelet function tests in Northern Europe. Methods A total of 14 clinical centres from Sweden (six), Finland (two), Denmark (two), Norway (one), Estonia (two) and Iceland (one) completed the survey questionnaire, the population capture area of about 29.5 million. Results Six of the 14 (42.8%) centres providing platelet function assessment represent comprehensive treatment centres (EUHANET status). A Bleeding score (BS) or ISTH bleeding assessment tool (ISTH BAT score) is evaluated in 11/14 (78.6%) centres and family history in all. Five/14 centres (35.7%) use structured preanalytical patient instructions, and 10/14 (71.4%) recorded questionnaire on the preassessment of avoidance of any drugs or natural products affecting platelet functions. Preliminary investigations of screening tests of coagulation are performed in 10/14 (71.4%), while in 4/14 (28.6%), the diagnostic work-up of IPFD and von Willebrand disease (VWD) is performed simultaneously. The work-up of IPFD includes peripheral blood smear in 10/14 (71.4%), platelet aggregometry in all, flow cytometry in 10/14 (71.4%) and Platelet Function Analysis (PFA) in 3/11 (28.6%). Molecular genetic diagnosis is available in 7/14 (50%) centres. Conclusions The considerable variability in the current practice illustrates the need for harmonization between the Northern European centres according to the international registers (i.e. EUHASS) and IPFD guidelines (ISTH, EHA). Peer reviewed |
author2 |
Clinicum University of Helsinki HUS Comprehensive Cancer Center Hematologian yksikkö Research Program in Systems Oncology Department of Oncology |
format |
Article in Journal/Newspaper |
author |
Nordic Haemophilia Council Szanto, Timea Zetterberg, Eva Ramström, Sofia Kärkkäinen, Satu Lassila, Riitta |
author_facet |
Nordic Haemophilia Council Szanto, Timea Zetterberg, Eva Ramström, Sofia Kärkkäinen, Satu Lassila, Riitta |
author_sort |
Nordic Haemophilia Council |
title |
Platelet function testing : Current practice among clinical centres in Northern Europe |
title_short |
Platelet function testing : Current practice among clinical centres in Northern Europe |
title_full |
Platelet function testing : Current practice among clinical centres in Northern Europe |
title_fullStr |
Platelet function testing : Current practice among clinical centres in Northern Europe |
title_full_unstemmed |
Platelet function testing : Current practice among clinical centres in Northern Europe |
title_sort |
platelet function testing : current practice among clinical centres in northern europe |
publisher |
Wiley |
publishDate |
2022 |
url |
http://hdl.handle.net/10138/346639 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
10.1111/hae.14578 We acknowledge all centres and their staff for their participation to this study. This article was funded by Helsinki University Hospital grant TYH2020318. Nordic Haemophilia Council , Szanto , T , Zetterberg , E , Ramström , S , Kärkkäinen , S & Lassila , R 2022 , ' Platelet function testing : Current practice among clinical centres in Northern Europe ' , Haemophilia , vol. 28 , no. 4 , pp. 642-648 . https://doi.org/10.1111/hae.14578 64bb51a7-bd6a-4fa1-8510-4131fd734dbf http://hdl.handle.net/10138/346639 000790857600001 |
op_rights |
cc_by_nc openAccess info:eu-repo/semantics/openAccess |
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Haemophilia |
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28 |
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4 |
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