High Lipid Content of Prey Fish and n-3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflected in Hepatic Biochemical Indices
Signs of impaired thiamine (vitamin B1) status in feeding-migrating Atlantic salmon (Salmo salar) were studied in three Baltic Sea areas, which differ in the proportion and nutritional composition of prey fish sprat (Sprattus sprattus) and herring (Clupea harengus). The concentration of n-3 polyunsa...
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/343267 2024-01-07T09:42:13+01:00 High Lipid Content of Prey Fish and n-3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflected in Hepatic Biochemical Indices Keinänen, Marja Nikonen, Soili Käkelä, Reijo Ritvanen, Tiina Rokka, Mervi Myllylä, Timo Pönni, Jukka Vuorinen, Pekka J. Molecular and Integrative Biosciences Research Programme Functional Lipidomics Group Helsinki Institute of Life Science HiLIFE Viikki Biocenter Biosciences 2022-05-03T12:45:07Z 27 application/pdf http://hdl.handle.net/10138/343267 eng eng MDPI 10.3390/biom12040526 This researchwas partly funded by the Academy of Finland (project DIOXMODE, No. 102557, in the Baltic Sea Research Programme BIREME). Keinänen , M , Nikonen , S , Käkelä , R , Ritvanen , T , Rokka , M , Myllylä , T , Pönni , J & Vuorinen , P J 2022 , ' High Lipid Content of Prey Fish and n-3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflected in Hepatic Biochemical Indices ' , Biomolecules , vol. 12 , no. 4 , 526 . https://doi.org/10.3390/biom12040526 ORCID: /0000-0002-8385-3695/work/133568281 e3932b0a-a0bb-423d-b5e4-452b929bc16a http://hdl.handle.net/10138/343267 000785297400001 cc_by openAccess info:eu-repo/semantics/openAccess Atlantic salmon Salmo salar Baltic Sea herring Clupea harengus lipid peroxidation M74 syndrome malondialdehyde polyunsaturated fatty acids sprat Sprattus sprattus thiamine total lipids HERRING CLUPEA-HARENGUS SPRAT SPRATTUS-SPRATTUS OXIDATIVE STRESS FATTY-ACIDS REPRODUCTIVE DISORDER DEFICIENCY METABOLISM DIET 1182 Biochemistry cell and molecular biology Article publishedVersion 2022 ftunivhelsihelda 2023-12-14T00:06:57Z Signs of impaired thiamine (vitamin B1) status in feeding-migrating Atlantic salmon (Salmo salar) were studied in three Baltic Sea areas, which differ in the proportion and nutritional composition of prey fish sprat (Sprattus sprattus) and herring (Clupea harengus). The concentration of n-3 polyunsaturated fatty acids (n-3 PUFAs) increased in salmon with dietary lipids and n-3 PUFAs, and the hepatic peroxidation product malondialdehyde (MDA) concentration increased exponentially with increasing n-3 PUFA and docosahexaenoic acid (DHA, 22:6n-3) concentration, whereas hepatic total thiamine concentration, a sensitive indicator of thiamine status, decreased with the increase in both body lipid and n-3 PUFA or DHA concentration. The hepatic glucose 6-phosphate dehydrogenase activity was suppressed by high dietary lipids. In salmon muscle and in prey fish, the proportion of thiamine pyrophosphate increased, and that of free thiamine decreased, with increasing body lipid content or PUFAs, or merely DHA. The thiamine status of salmon was impaired mainly due to the peroxidation of n-3 PUFAs, whereas lipids as a source of metabolic energy had less effect. Organochlorines or general oxidative stress did not affect the thiamine status. The amount of lipids, and, specifically, their long-chain n-3 PUFAs, are thus responsible for generating thiamine deficiency, and not a prey fish species per se. Peer reviewed Article in Journal/Newspaper Atlantic salmon Salmo salar HELDA – University of Helsinki Open Repository Biomolecules 12 4 526 |
institution |
Open Polar |
collection |
HELDA – University of Helsinki Open Repository |
op_collection_id |
ftunivhelsihelda |
language |
English |
topic |
Atlantic salmon Salmo salar Baltic Sea herring Clupea harengus lipid peroxidation M74 syndrome malondialdehyde polyunsaturated fatty acids sprat Sprattus sprattus thiamine total lipids HERRING CLUPEA-HARENGUS SPRAT SPRATTUS-SPRATTUS OXIDATIVE STRESS FATTY-ACIDS REPRODUCTIVE DISORDER DEFICIENCY METABOLISM DIET 1182 Biochemistry cell and molecular biology |
spellingShingle |
Atlantic salmon Salmo salar Baltic Sea herring Clupea harengus lipid peroxidation M74 syndrome malondialdehyde polyunsaturated fatty acids sprat Sprattus sprattus thiamine total lipids HERRING CLUPEA-HARENGUS SPRAT SPRATTUS-SPRATTUS OXIDATIVE STRESS FATTY-ACIDS REPRODUCTIVE DISORDER DEFICIENCY METABOLISM DIET 1182 Biochemistry cell and molecular biology Keinänen, Marja Nikonen, Soili Käkelä, Reijo Ritvanen, Tiina Rokka, Mervi Myllylä, Timo Pönni, Jukka Vuorinen, Pekka J. High Lipid Content of Prey Fish and n-3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflected in Hepatic Biochemical Indices |
topic_facet |
Atlantic salmon Salmo salar Baltic Sea herring Clupea harengus lipid peroxidation M74 syndrome malondialdehyde polyunsaturated fatty acids sprat Sprattus sprattus thiamine total lipids HERRING CLUPEA-HARENGUS SPRAT SPRATTUS-SPRATTUS OXIDATIVE STRESS FATTY-ACIDS REPRODUCTIVE DISORDER DEFICIENCY METABOLISM DIET 1182 Biochemistry cell and molecular biology |
description |
Signs of impaired thiamine (vitamin B1) status in feeding-migrating Atlantic salmon (Salmo salar) were studied in three Baltic Sea areas, which differ in the proportion and nutritional composition of prey fish sprat (Sprattus sprattus) and herring (Clupea harengus). The concentration of n-3 polyunsaturated fatty acids (n-3 PUFAs) increased in salmon with dietary lipids and n-3 PUFAs, and the hepatic peroxidation product malondialdehyde (MDA) concentration increased exponentially with increasing n-3 PUFA and docosahexaenoic acid (DHA, 22:6n-3) concentration, whereas hepatic total thiamine concentration, a sensitive indicator of thiamine status, decreased with the increase in both body lipid and n-3 PUFA or DHA concentration. The hepatic glucose 6-phosphate dehydrogenase activity was suppressed by high dietary lipids. In salmon muscle and in prey fish, the proportion of thiamine pyrophosphate increased, and that of free thiamine decreased, with increasing body lipid content or PUFAs, or merely DHA. The thiamine status of salmon was impaired mainly due to the peroxidation of n-3 PUFAs, whereas lipids as a source of metabolic energy had less effect. Organochlorines or general oxidative stress did not affect the thiamine status. The amount of lipids, and, specifically, their long-chain n-3 PUFAs, are thus responsible for generating thiamine deficiency, and not a prey fish species per se. Peer reviewed |
author2 |
Molecular and Integrative Biosciences Research Programme Functional Lipidomics Group Helsinki Institute of Life Science HiLIFE Viikki Biocenter Biosciences |
format |
Article in Journal/Newspaper |
author |
Keinänen, Marja Nikonen, Soili Käkelä, Reijo Ritvanen, Tiina Rokka, Mervi Myllylä, Timo Pönni, Jukka Vuorinen, Pekka J. |
author_facet |
Keinänen, Marja Nikonen, Soili Käkelä, Reijo Ritvanen, Tiina Rokka, Mervi Myllylä, Timo Pönni, Jukka Vuorinen, Pekka J. |
author_sort |
Keinänen, Marja |
title |
High Lipid Content of Prey Fish and n-3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflected in Hepatic Biochemical Indices |
title_short |
High Lipid Content of Prey Fish and n-3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflected in Hepatic Biochemical Indices |
title_full |
High Lipid Content of Prey Fish and n-3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflected in Hepatic Biochemical Indices |
title_fullStr |
High Lipid Content of Prey Fish and n-3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflected in Hepatic Biochemical Indices |
title_full_unstemmed |
High Lipid Content of Prey Fish and n-3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflected in Hepatic Biochemical Indices |
title_sort |
high lipid content of prey fish and n-3 pufa peroxidation impair the thiamine status of feeding-migrating atlantic salmon (salmo salar) and is reflected in hepatic biochemical indices |
publisher |
MDPI |
publishDate |
2022 |
url |
http://hdl.handle.net/10138/343267 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
10.3390/biom12040526 This researchwas partly funded by the Academy of Finland (project DIOXMODE, No. 102557, in the Baltic Sea Research Programme BIREME). Keinänen , M , Nikonen , S , Käkelä , R , Ritvanen , T , Rokka , M , Myllylä , T , Pönni , J & Vuorinen , P J 2022 , ' High Lipid Content of Prey Fish and n-3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflected in Hepatic Biochemical Indices ' , Biomolecules , vol. 12 , no. 4 , 526 . https://doi.org/10.3390/biom12040526 ORCID: /0000-0002-8385-3695/work/133568281 e3932b0a-a0bb-423d-b5e4-452b929bc16a http://hdl.handle.net/10138/343267 000785297400001 |
op_rights |
cc_by openAccess info:eu-repo/semantics/openAccess |
container_title |
Biomolecules |
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12 |
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4 |
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526 |
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1787423147277942784 |