Compensatory IgM to the Rescue: Patients with Selective IgA Deficiency Have Increased Natural IgM Antibodies to MAA-LDL and No Changes in Oral Microbiota
IgA is the most abundant Ab in the human body. However, most patients with selective IgA deficiency (SIgAD) are asymptomatic. IgM, and to lesser extent IgG Abs, are generally presumed to compensate for the lack of IgA in SIgAD by multiplying and adopting functions of IgA. We used data from the North...
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The American Association of Immunologists
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/340982 2024-01-07T09:45:27+01:00 Compensatory IgM to the Rescue: Patients with Selective IgA Deficiency Have Increased Natural IgM Antibodies to MAA-LDL and No Changes in Oral Microbiota Mella, Miia A. Lavrinienko, Anton Akhi, Ramin Hindström, Rasmus Nissinen, Antti E. Wang, Chunguang Kullaa, Arja M. Salo, Tuula Auvinen, Juha Koskimäki, Janne Hörkko, Sohvi Medicum HUSLAB Department of Oral and Maxillofacial Diseases TRIMM - Translational Immunology Research Program Department of Pathology 2022-02-25T08:24:01Z 12 application/pdf http://hdl.handle.net/10138/340982 eng eng The American Association of Immunologists 10.4049/immunohorizons.2100014 Mella , M A , Lavrinienko , A , Akhi , R , Hindström , R , Nissinen , A E , Wang , C , Kullaa , A M , Salo , T , Auvinen , J , Koskimäki , J & Hörkko , S 2021 , ' Compensatory IgM to the Rescue: Patients with Selective IgA Deficiency Have Increased Natural IgM Antibodies to MAA-LDL and No Changes in Oral Microbiota ' , ImmunoHorizons , vol. 5 , no. 4 , http://www.immunohorizons.org/content/5/4/170 , pp. 170-181 . https://doi.org/10.4049/immunohorizons.2100014 ORCID: /0000-0001-6039-0088/work/108865325 ORCID: /0000-0001-5569-321X/work/108869392 a94340a2-2fec-4a1a-9c4b-86f21908aed5 http://hdl.handle.net/10138/340982 cc_by_nc_nd openAccess info:eu-repo/semantics/openAccess 3111 Biomedicine Article publishedVersion 2022 ftunivhelsihelda 2023-12-14T00:13:09Z IgA is the most abundant Ab in the human body. However, most patients with selective IgA deficiency (SIgAD) are asymptomatic. IgM, and to lesser extent IgG Abs, are generally presumed to compensate for the lack of IgA in SIgAD by multiplying and adopting functions of IgA. We used data from the Northern Finland Birth Cohort 1966 to investigate whether SIgAD patients have differences in levels of natural Abs to oxidized epitopes compared with 20 randomly selected healthy controls. First, we screened the saliva and serum samples from the Northern Finland Birth Cohort 1966 cohort (n 5 1610) for IgA concentration. We detected five IgA-deficient subjects, yielding a prevalence of 0.3%, which is consistent with the general prevalence of 0.25% in the Finnish population. To detect natural Abs, we used malondialdehyde acetaldehyde–low-density lipoprotein (MAA–LDL), an Ag known to bind natural Abs. In this study, we show that natural secretory IgM and IgG Abs to MAA–DL were significantly increased in subjects with SIgAD. Given that secretory IgA is an important part of mucosal immune defense and that, in the gut microbiota, dysbiosis with SIgAD patients has been observed, we characterized the oral bacterial microbiota of the subjects with and without SIgAD using high-throughput 16S rRNA gene sequencing. We found no significant alterations in diversity and composition of the oral microbiota in subjects with SIgAD. Our data suggest that increased levels of secretory natural Abs in patients with SIgAD could be a compensatory mechanism, providing alternative first-line defense against infections and adjusting mucosal milieu to maintain a healthy oral microbiota. ImmunoHorizons, 2021, 5: 170–181. Peer reviewed Article in Journal/Newspaper Northern Finland HELDA – University of Helsinki Open Repository ImmunoHorizons 5 4 170 181 |
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ftunivhelsihelda |
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English |
topic |
3111 Biomedicine |
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3111 Biomedicine Mella, Miia A. Lavrinienko, Anton Akhi, Ramin Hindström, Rasmus Nissinen, Antti E. Wang, Chunguang Kullaa, Arja M. Salo, Tuula Auvinen, Juha Koskimäki, Janne Hörkko, Sohvi Compensatory IgM to the Rescue: Patients with Selective IgA Deficiency Have Increased Natural IgM Antibodies to MAA-LDL and No Changes in Oral Microbiota |
topic_facet |
3111 Biomedicine |
description |
IgA is the most abundant Ab in the human body. However, most patients with selective IgA deficiency (SIgAD) are asymptomatic. IgM, and to lesser extent IgG Abs, are generally presumed to compensate for the lack of IgA in SIgAD by multiplying and adopting functions of IgA. We used data from the Northern Finland Birth Cohort 1966 to investigate whether SIgAD patients have differences in levels of natural Abs to oxidized epitopes compared with 20 randomly selected healthy controls. First, we screened the saliva and serum samples from the Northern Finland Birth Cohort 1966 cohort (n 5 1610) for IgA concentration. We detected five IgA-deficient subjects, yielding a prevalence of 0.3%, which is consistent with the general prevalence of 0.25% in the Finnish population. To detect natural Abs, we used malondialdehyde acetaldehyde–low-density lipoprotein (MAA–LDL), an Ag known to bind natural Abs. In this study, we show that natural secretory IgM and IgG Abs to MAA–DL were significantly increased in subjects with SIgAD. Given that secretory IgA is an important part of mucosal immune defense and that, in the gut microbiota, dysbiosis with SIgAD patients has been observed, we characterized the oral bacterial microbiota of the subjects with and without SIgAD using high-throughput 16S rRNA gene sequencing. We found no significant alterations in diversity and composition of the oral microbiota in subjects with SIgAD. Our data suggest that increased levels of secretory natural Abs in patients with SIgAD could be a compensatory mechanism, providing alternative first-line defense against infections and adjusting mucosal milieu to maintain a healthy oral microbiota. ImmunoHorizons, 2021, 5: 170–181. Peer reviewed |
author2 |
Medicum HUSLAB Department of Oral and Maxillofacial Diseases TRIMM - Translational Immunology Research Program Department of Pathology |
format |
Article in Journal/Newspaper |
author |
Mella, Miia A. Lavrinienko, Anton Akhi, Ramin Hindström, Rasmus Nissinen, Antti E. Wang, Chunguang Kullaa, Arja M. Salo, Tuula Auvinen, Juha Koskimäki, Janne Hörkko, Sohvi |
author_facet |
Mella, Miia A. Lavrinienko, Anton Akhi, Ramin Hindström, Rasmus Nissinen, Antti E. Wang, Chunguang Kullaa, Arja M. Salo, Tuula Auvinen, Juha Koskimäki, Janne Hörkko, Sohvi |
author_sort |
Mella, Miia A. |
title |
Compensatory IgM to the Rescue: Patients with Selective IgA Deficiency Have Increased Natural IgM Antibodies to MAA-LDL and No Changes in Oral Microbiota |
title_short |
Compensatory IgM to the Rescue: Patients with Selective IgA Deficiency Have Increased Natural IgM Antibodies to MAA-LDL and No Changes in Oral Microbiota |
title_full |
Compensatory IgM to the Rescue: Patients with Selective IgA Deficiency Have Increased Natural IgM Antibodies to MAA-LDL and No Changes in Oral Microbiota |
title_fullStr |
Compensatory IgM to the Rescue: Patients with Selective IgA Deficiency Have Increased Natural IgM Antibodies to MAA-LDL and No Changes in Oral Microbiota |
title_full_unstemmed |
Compensatory IgM to the Rescue: Patients with Selective IgA Deficiency Have Increased Natural IgM Antibodies to MAA-LDL and No Changes in Oral Microbiota |
title_sort |
compensatory igm to the rescue: patients with selective iga deficiency have increased natural igm antibodies to maa-ldl and no changes in oral microbiota |
publisher |
The American Association of Immunologists |
publishDate |
2022 |
url |
http://hdl.handle.net/10138/340982 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
10.4049/immunohorizons.2100014 Mella , M A , Lavrinienko , A , Akhi , R , Hindström , R , Nissinen , A E , Wang , C , Kullaa , A M , Salo , T , Auvinen , J , Koskimäki , J & Hörkko , S 2021 , ' Compensatory IgM to the Rescue: Patients with Selective IgA Deficiency Have Increased Natural IgM Antibodies to MAA-LDL and No Changes in Oral Microbiota ' , ImmunoHorizons , vol. 5 , no. 4 , http://www.immunohorizons.org/content/5/4/170 , pp. 170-181 . https://doi.org/10.4049/immunohorizons.2100014 ORCID: /0000-0001-6039-0088/work/108865325 ORCID: /0000-0001-5569-321X/work/108869392 a94340a2-2fec-4a1a-9c4b-86f21908aed5 http://hdl.handle.net/10138/340982 |
op_rights |
cc_by_nc_nd openAccess info:eu-repo/semantics/openAccess |
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ImmunoHorizons |
container_volume |
5 |
container_issue |
4 |
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170 |
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181 |
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1787426986249945088 |