Hyperglycemia as a risk factor in pancreatic cancer : A nested case-control study using prediagnostic blood glucose levels
Objective: To determine the risk association between fasting glucose levels and pancreatic cancer using systematically collected prediagnostic blood glucose samples. Methods: Prospective nested case-control study of participants from the Northern Sweden Health and Disease Study, including 182 cases...
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/340075 2024-01-07T09:45:33+01:00 Hyperglycemia as a risk factor in pancreatic cancer : A nested case-control study using prediagnostic blood glucose levels Jacobson, Sara Dahlqvist, Per Johansson, Mattias Svensson, Johan Billing, Ola Sund, Malin Franklin, Oskar Department of Surgery HUS Abdominal Center 2022-02-10T16:38:01Z 7 application/pdf http://hdl.handle.net/10138/340075 eng eng Elsevier Scientific Publ. Co 10.1016/j.pan.2021.05.008 This study was funded by grants from the medical faculty at Umea University (223-1828-13 for Oskar Franklin), Bengt Ihres Foundation (SLS-885861), the Claes Groschinsky Memorial Foundation (M 19391), Lions Cancer Research Foundation, Umea University (LS 18e140 for Sara Jacobson), the Swedish Research Council (2016-02990 and 2019-01690 for Malin Sund), the Swedish Cancer Society (CAN 2016-643 and 19027 for Malin Sund), the Sj_oberg Foundation (for Malin Sund) and Region V_asterbotten (RV837731 and RV 930132 for Oskar Franklin. RV-841551 and RV583411 for Malin Sund). The funders had no role in the design of the study, data collection, data analysis, interpretation of data or in writing the manuscript. Jacobson , S , Dahlqvist , P , Johansson , M , Svensson , J , Billing , O , Sund , M & Franklin , O 2021 , ' Hyperglycemia as a risk factor in pancreatic cancer : A nested case-control study using prediagnostic blood glucose levels ' , Pancreatology , vol. 21 , no. 6 , pp. 1112-1118 . https://doi.org/10.1016/j.pan.2021.05.008 ORCID: /0000-0002-7516-9543/work/108072146 f7b1a8f1-f2dc-4d34-af0b-2727894e1d4e http://hdl.handle.net/10138/340075 000727779500013 cc_by openAccess info:eu-repo/semantics/openAccess Early detection Fasting glucose Pancreatic ductal adenocarcinoma Risk analysis DIABETES-MELLITUS ASSOCIATION PREVALENCE DIAGNOSIS RESECTION SURVIVAL PROGRAM ONSET 3121 General medicine internal medicine and other clinical medicine Article publishedVersion 2022 ftunivhelsihelda 2023-12-14T00:04:27Z Objective: To determine the risk association between fasting glucose levels and pancreatic cancer using systematically collected prediagnostic blood glucose samples. Methods: Prospective nested case-control study of participants from the Northern Sweden Health and Disease Study, including 182 cases that developed pancreatic cancer and four matched controls per case. Blood glucose levels collected up to 24 years before pancreatic cancer diagnosis were analyzed. The association between fasting glucose levels and pancreatic cancer risk was determined using unconditional and conditional logistic regression models. The association between fasting glucose and the time to pancreatic cancer diagnosis, tumor stage and survival was determined using likelihood-ratio test, t test and log rank test. Results: The unadjusted risk of developing pancreatic cancer increased with increasing fasting glucose levels (OR 1.30, 95% CI 1.05-1.60, P = .015). Impaired fasting glucose (>6.1 mmol/L) was associated with an adjusted risk of 1.77 for developing pancreatic cancer (95% CI 1.05-2.99, P = .032). In subgroup analysis, fasting glucose levels were associated with an increased risk in never-smokers (OR 4.02, 95% CI 1.26-12.77, P = .018) and non-diabetics (OR 3.08, 95% CI 1.08-8.79, P = .035) (non-significant for interaction). The ratio between fasting glucose and BMI was higher among future pancreatic cancer patients and an increased ratio was associated with elevated risk of pancreatic cancer (OR 1.66, 95% CI 1.04-2.66, P = .034). Fasting glucose levels were not associated with TNM stage at diagnosis or survival. Conclusions: High fasting glucose is associated with an increased risk of being diagnosed with pancreatic cancer. (c) 2021 The Authors. Published by Elsevier B.V. on behalf of IAP and EPC. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Peer reviewed Article in Journal/Newspaper Northern Sweden HELDA – University of Helsinki Open Repository TNM ENVELOPE(-58.100,-58.100,-62.000,-62.000) Pancreatology 21 6 1112 1118 |
institution |
Open Polar |
collection |
HELDA – University of Helsinki Open Repository |
op_collection_id |
ftunivhelsihelda |
language |
English |
topic |
Early detection Fasting glucose Pancreatic ductal adenocarcinoma Risk analysis DIABETES-MELLITUS ASSOCIATION PREVALENCE DIAGNOSIS RESECTION SURVIVAL PROGRAM ONSET 3121 General medicine internal medicine and other clinical medicine |
spellingShingle |
Early detection Fasting glucose Pancreatic ductal adenocarcinoma Risk analysis DIABETES-MELLITUS ASSOCIATION PREVALENCE DIAGNOSIS RESECTION SURVIVAL PROGRAM ONSET 3121 General medicine internal medicine and other clinical medicine Jacobson, Sara Dahlqvist, Per Johansson, Mattias Svensson, Johan Billing, Ola Sund, Malin Franklin, Oskar Hyperglycemia as a risk factor in pancreatic cancer : A nested case-control study using prediagnostic blood glucose levels |
topic_facet |
Early detection Fasting glucose Pancreatic ductal adenocarcinoma Risk analysis DIABETES-MELLITUS ASSOCIATION PREVALENCE DIAGNOSIS RESECTION SURVIVAL PROGRAM ONSET 3121 General medicine internal medicine and other clinical medicine |
description |
Objective: To determine the risk association between fasting glucose levels and pancreatic cancer using systematically collected prediagnostic blood glucose samples. Methods: Prospective nested case-control study of participants from the Northern Sweden Health and Disease Study, including 182 cases that developed pancreatic cancer and four matched controls per case. Blood glucose levels collected up to 24 years before pancreatic cancer diagnosis were analyzed. The association between fasting glucose levels and pancreatic cancer risk was determined using unconditional and conditional logistic regression models. The association between fasting glucose and the time to pancreatic cancer diagnosis, tumor stage and survival was determined using likelihood-ratio test, t test and log rank test. Results: The unadjusted risk of developing pancreatic cancer increased with increasing fasting glucose levels (OR 1.30, 95% CI 1.05-1.60, P = .015). Impaired fasting glucose (>6.1 mmol/L) was associated with an adjusted risk of 1.77 for developing pancreatic cancer (95% CI 1.05-2.99, P = .032). In subgroup analysis, fasting glucose levels were associated with an increased risk in never-smokers (OR 4.02, 95% CI 1.26-12.77, P = .018) and non-diabetics (OR 3.08, 95% CI 1.08-8.79, P = .035) (non-significant for interaction). The ratio between fasting glucose and BMI was higher among future pancreatic cancer patients and an increased ratio was associated with elevated risk of pancreatic cancer (OR 1.66, 95% CI 1.04-2.66, P = .034). Fasting glucose levels were not associated with TNM stage at diagnosis or survival. Conclusions: High fasting glucose is associated with an increased risk of being diagnosed with pancreatic cancer. (c) 2021 The Authors. Published by Elsevier B.V. on behalf of IAP and EPC. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Peer reviewed |
author2 |
Department of Surgery HUS Abdominal Center |
format |
Article in Journal/Newspaper |
author |
Jacobson, Sara Dahlqvist, Per Johansson, Mattias Svensson, Johan Billing, Ola Sund, Malin Franklin, Oskar |
author_facet |
Jacobson, Sara Dahlqvist, Per Johansson, Mattias Svensson, Johan Billing, Ola Sund, Malin Franklin, Oskar |
author_sort |
Jacobson, Sara |
title |
Hyperglycemia as a risk factor in pancreatic cancer : A nested case-control study using prediagnostic blood glucose levels |
title_short |
Hyperglycemia as a risk factor in pancreatic cancer : A nested case-control study using prediagnostic blood glucose levels |
title_full |
Hyperglycemia as a risk factor in pancreatic cancer : A nested case-control study using prediagnostic blood glucose levels |
title_fullStr |
Hyperglycemia as a risk factor in pancreatic cancer : A nested case-control study using prediagnostic blood glucose levels |
title_full_unstemmed |
Hyperglycemia as a risk factor in pancreatic cancer : A nested case-control study using prediagnostic blood glucose levels |
title_sort |
hyperglycemia as a risk factor in pancreatic cancer : a nested case-control study using prediagnostic blood glucose levels |
publisher |
Elsevier Scientific Publ. Co |
publishDate |
2022 |
url |
http://hdl.handle.net/10138/340075 |
long_lat |
ENVELOPE(-58.100,-58.100,-62.000,-62.000) |
geographic |
TNM |
geographic_facet |
TNM |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
10.1016/j.pan.2021.05.008 This study was funded by grants from the medical faculty at Umea University (223-1828-13 for Oskar Franklin), Bengt Ihres Foundation (SLS-885861), the Claes Groschinsky Memorial Foundation (M 19391), Lions Cancer Research Foundation, Umea University (LS 18e140 for Sara Jacobson), the Swedish Research Council (2016-02990 and 2019-01690 for Malin Sund), the Swedish Cancer Society (CAN 2016-643 and 19027 for Malin Sund), the Sj_oberg Foundation (for Malin Sund) and Region V_asterbotten (RV837731 and RV 930132 for Oskar Franklin. RV-841551 and RV583411 for Malin Sund). The funders had no role in the design of the study, data collection, data analysis, interpretation of data or in writing the manuscript. Jacobson , S , Dahlqvist , P , Johansson , M , Svensson , J , Billing , O , Sund , M & Franklin , O 2021 , ' Hyperglycemia as a risk factor in pancreatic cancer : A nested case-control study using prediagnostic blood glucose levels ' , Pancreatology , vol. 21 , no. 6 , pp. 1112-1118 . https://doi.org/10.1016/j.pan.2021.05.008 ORCID: /0000-0002-7516-9543/work/108072146 f7b1a8f1-f2dc-4d34-af0b-2727894e1d4e http://hdl.handle.net/10138/340075 000727779500013 |
op_rights |
cc_by openAccess info:eu-repo/semantics/openAccess |
container_title |
Pancreatology |
container_volume |
21 |
container_issue |
6 |
container_start_page |
1112 |
op_container_end_page |
1118 |
_version_ |
1787427117506494464 |