Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm
Objective: It has been suggested that adverse early life exposures increase the risk of developing polycystic ovary syndrome (PCOS) in later life. We hypothesized that women born preterm would have more biochemical and clinical signs of PCOS than women born at term. Design: The ESTER Preterm Birth S...
Published in: | European Journal of Endocrinology |
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Main Authors: | , , , , , , , , , |
Other Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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BIOSCIENTIFICA LTD
2022
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Online Access: | http://hdl.handle.net/10138/339633 |
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/339633 |
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Open Polar |
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HELDA – University of Helsinki Open Repository |
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ftunivhelsihelda |
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English |
topic |
LOW-BIRTH-WEIGHT OLIGOMENORRHEA AND/OR HIRSUTISM HORMONE-BINDING GLOBULIN SELF-REPORTED SYMPTOMS PRECOCIOUS PUBARCHE MENSTRUAL-CYCLE RISK-FACTORS PREVALENCE ADULTS HYPERANDROGENISM 3123 Gynaecology and paediatrics |
spellingShingle |
LOW-BIRTH-WEIGHT OLIGOMENORRHEA AND/OR HIRSUTISM HORMONE-BINDING GLOBULIN SELF-REPORTED SYMPTOMS PRECOCIOUS PUBARCHE MENSTRUAL-CYCLE RISK-FACTORS PREVALENCE ADULTS HYPERANDROGENISM 3123 Gynaecology and paediatrics Paalanne, Marika Vääräsmäki, Marja Mustaniemi, Sanna Tikanmäki, Marjaana Wehkalampi, Karoliina Matinolli, Hanna-Maria Eriksson, Johan Järvelin, Marjo-Riitta Morin-Papunen, Laure Kajantie, Eero Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
topic_facet |
LOW-BIRTH-WEIGHT OLIGOMENORRHEA AND/OR HIRSUTISM HORMONE-BINDING GLOBULIN SELF-REPORTED SYMPTOMS PRECOCIOUS PUBARCHE MENSTRUAL-CYCLE RISK-FACTORS PREVALENCE ADULTS HYPERANDROGENISM 3123 Gynaecology and paediatrics |
description |
Objective: It has been suggested that adverse early life exposures increase the risk of developing polycystic ovary syndrome (PCOS) in later life. We hypothesized that women born preterm would have more biochemical and clinical signs of PCOS than women born at term. Design: The ESTER Preterm Birth Study participants were born in Northern Finland and identified from the Northern Finland Birth Cohort and the Finnish Medical Birth Register. Altogether, 74 women born very or moderately preterm (= 37 weeks, controls) were included in the analysis (mean age: 23.2 years). Methods: We measured serum total testosterone and sex hormone-binding globulin (SHBG) and calculated the free androgen index (FAI). PCOS according to the clinical and biochemical signs was defined either as hirsutism and oligoamenorrhea (via questionnaire) or as oligoamenorrhea and elevated testosterone levels (>2.4 nmol/L). Results: Women born VMPT/LPT exhibited 33.0% (8.7, 62.8)/16.4% (-2.0, 38.1) higher testosterone, 28.5% (5.3, 45.9)/24.1% (5.6, 38.9) lower SHBG levels, and 64.6% (19.4, 127.1)/42.5% (11.1, 82.9) higher FAI than controls after adjusting for age and recruitment cohort, maternal BMI, smoking, and pregnancy disorders, parental education, history of hypertension, diabetes, myocardial infarction or stroke, and subject's birth weight s.D. Odds ratios for having PCOS were 1.67 (0.44, 6.23)/3.11 (1.26, 7.70). Conclusions: Women born preterm have a more hyperandrogenic hormonal profile, and those born LPT are approximately three times more likely at risk to have PCOS compared to women born at term. Peer reviewed |
author2 |
HUS Children and Adolescents Children's Hospital University of Helsinki Clinicum Research Programs Unit Johan Eriksson / Principal Investigator Department of General Practice and Primary Health Care Lastentautien yksikkö |
format |
Article in Journal/Newspaper |
author |
Paalanne, Marika Vääräsmäki, Marja Mustaniemi, Sanna Tikanmäki, Marjaana Wehkalampi, Karoliina Matinolli, Hanna-Maria Eriksson, Johan Järvelin, Marjo-Riitta Morin-Papunen, Laure Kajantie, Eero |
author_facet |
Paalanne, Marika Vääräsmäki, Marja Mustaniemi, Sanna Tikanmäki, Marjaana Wehkalampi, Karoliina Matinolli, Hanna-Maria Eriksson, Johan Järvelin, Marjo-Riitta Morin-Papunen, Laure Kajantie, Eero |
author_sort |
Paalanne, Marika |
title |
Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
title_short |
Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
title_full |
Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
title_fullStr |
Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
title_full_unstemmed |
Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
title_sort |
clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
publisher |
BIOSCIENTIFICA LTD |
publishDate |
2022 |
url |
http://hdl.handle.net/10138/339633 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
10.1530/EJE-20-1462 The ESTER study was supported by grants from the Academy of Finland (SALVE program for 2009-2012 and grants 127437, 129306, 130326, 134791, 263924 and 315690 to E K) , the Emil Aaltonen Foundation, the European Commission (Framework 5 award QLG1-CT-2000-001643; to M R J and Horizon 2020 award 733280 RECAP Research for Children and Adults Born Preterm to E K) , Norface DIAL 462-16-040 Award PremLife to E K, the Finnish Foundation for Pediatric Research, the Finnish Government Special Subsidiary for Health Sciences (evo) , the Finnish Medical Society: Duodecim, the Jalmari and Rauha Ahokas Foundation, the Juho Vainio Foundation, the Novo Nordisk Foundation, the Signe and Ane Gyllenberg Foundation, the Sigrid Juselius Foundation, the Jenny and Antti Wihuri Foundation, and the Yrjo Jahnsson Foundation. In addition, NFBC 1986 received financial support from the Academy of Finland (grants 175617, 173454, 24300269, and 24300217) EU FP7-ENV-2008-1-226534; USA/NIH/NHLBI 1-R01-HL087679-01; RFP-RM-06-008; NorFA (50847) Thule Institute (50925) Oulu University Hospital, Oulu, Finland (24301140) and the University of Oulu, Finland (24000692, 24500283) . Paalanne , M , Vääräsmäki , M , Mustaniemi , S , Tikanmäki , M , Wehkalampi , K , Matinolli , H-M , Eriksson , J , Järvelin , M-R , Morin-Papunen , L & Kajantie , E 2021 , ' Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm ' , European Journal of Endocrinology , vol. 185 , no. 2 , pp. 279-288 . https://doi.org/10.1530/EJE-20-1462 87759c04-eb04-43b7-9933-a654d01770a2 http://hdl.handle.net/10138/339633 000691788100014 |
op_rights |
cc_by openAccess info:eu-repo/semantics/openAccess |
container_title |
European Journal of Endocrinology |
container_volume |
185 |
container_issue |
2 |
container_start_page |
279 |
op_container_end_page |
288 |
_version_ |
1787426985850437632 |
spelling |
ftunivhelsihelda:oai:helda.helsinki.fi:10138/339633 2024-01-07T09:45:27+01:00 Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm Paalanne, Marika Vääräsmäki, Marja Mustaniemi, Sanna Tikanmäki, Marjaana Wehkalampi, Karoliina Matinolli, Hanna-Maria Eriksson, Johan Järvelin, Marjo-Riitta Morin-Papunen, Laure Kajantie, Eero HUS Children and Adolescents Children's Hospital University of Helsinki Clinicum Research Programs Unit Johan Eriksson / Principal Investigator Department of General Practice and Primary Health Care Lastentautien yksikkö 2022-02-02T10:43:03Z 10 application/pdf http://hdl.handle.net/10138/339633 eng eng BIOSCIENTIFICA LTD 10.1530/EJE-20-1462 The ESTER study was supported by grants from the Academy of Finland (SALVE program for 2009-2012 and grants 127437, 129306, 130326, 134791, 263924 and 315690 to E K) , the Emil Aaltonen Foundation, the European Commission (Framework 5 award QLG1-CT-2000-001643; to M R J and Horizon 2020 award 733280 RECAP Research for Children and Adults Born Preterm to E K) , Norface DIAL 462-16-040 Award PremLife to E K, the Finnish Foundation for Pediatric Research, the Finnish Government Special Subsidiary for Health Sciences (evo) , the Finnish Medical Society: Duodecim, the Jalmari and Rauha Ahokas Foundation, the Juho Vainio Foundation, the Novo Nordisk Foundation, the Signe and Ane Gyllenberg Foundation, the Sigrid Juselius Foundation, the Jenny and Antti Wihuri Foundation, and the Yrjo Jahnsson Foundation. In addition, NFBC 1986 received financial support from the Academy of Finland (grants 175617, 173454, 24300269, and 24300217) EU FP7-ENV-2008-1-226534; USA/NIH/NHLBI 1-R01-HL087679-01; RFP-RM-06-008; NorFA (50847) Thule Institute (50925) Oulu University Hospital, Oulu, Finland (24301140) and the University of Oulu, Finland (24000692, 24500283) . Paalanne , M , Vääräsmäki , M , Mustaniemi , S , Tikanmäki , M , Wehkalampi , K , Matinolli , H-M , Eriksson , J , Järvelin , M-R , Morin-Papunen , L & Kajantie , E 2021 , ' Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm ' , European Journal of Endocrinology , vol. 185 , no. 2 , pp. 279-288 . https://doi.org/10.1530/EJE-20-1462 87759c04-eb04-43b7-9933-a654d01770a2 http://hdl.handle.net/10138/339633 000691788100014 cc_by openAccess info:eu-repo/semantics/openAccess LOW-BIRTH-WEIGHT OLIGOMENORRHEA AND/OR HIRSUTISM HORMONE-BINDING GLOBULIN SELF-REPORTED SYMPTOMS PRECOCIOUS PUBARCHE MENSTRUAL-CYCLE RISK-FACTORS PREVALENCE ADULTS HYPERANDROGENISM 3123 Gynaecology and paediatrics Article publishedVersion 2022 ftunivhelsihelda 2023-12-14T00:11:44Z Objective: It has been suggested that adverse early life exposures increase the risk of developing polycystic ovary syndrome (PCOS) in later life. We hypothesized that women born preterm would have more biochemical and clinical signs of PCOS than women born at term. Design: The ESTER Preterm Birth Study participants were born in Northern Finland and identified from the Northern Finland Birth Cohort and the Finnish Medical Birth Register. Altogether, 74 women born very or moderately preterm (= 37 weeks, controls) were included in the analysis (mean age: 23.2 years). Methods: We measured serum total testosterone and sex hormone-binding globulin (SHBG) and calculated the free androgen index (FAI). PCOS according to the clinical and biochemical signs was defined either as hirsutism and oligoamenorrhea (via questionnaire) or as oligoamenorrhea and elevated testosterone levels (>2.4 nmol/L). Results: Women born VMPT/LPT exhibited 33.0% (8.7, 62.8)/16.4% (-2.0, 38.1) higher testosterone, 28.5% (5.3, 45.9)/24.1% (5.6, 38.9) lower SHBG levels, and 64.6% (19.4, 127.1)/42.5% (11.1, 82.9) higher FAI than controls after adjusting for age and recruitment cohort, maternal BMI, smoking, and pregnancy disorders, parental education, history of hypertension, diabetes, myocardial infarction or stroke, and subject's birth weight s.D. Odds ratios for having PCOS were 1.67 (0.44, 6.23)/3.11 (1.26, 7.70). Conclusions: Women born preterm have a more hyperandrogenic hormonal profile, and those born LPT are approximately three times more likely at risk to have PCOS compared to women born at term. Peer reviewed Article in Journal/Newspaper Northern Finland HELDA – University of Helsinki Open Repository European Journal of Endocrinology 185 2 279 288 |