Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection
Staphylococcus aureus is the most common cause of surgical site infections and its treatment is challenging due to the emergence of multi-drug resistant strains such as methicillin-resistant S. aureus (MRSA). Natural berry-derived compounds have shown antimicrobial potential, e.g., ellagitannins suc...
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Multidisciplinary Digital Publishing Institute
2021
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/337286 2023-05-15T18:07:47+02:00 Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection Aguilera-Correa, John Jairo Fernández-López, Sara Cuñas-Figueroa, Iskra Dennisse Pérez-Rial, Sandra Alakomi, Hanna-Leena Nohynek, Liisa Oksman-Caldentey, Kirsi-Marja Salminen, Juha-Pekka Esteban, Jaime Cuadros, Juan Puupponen-Pimiä, Riitta Pérez-Tanoira, Ramón Kinnari, Teemu J. 2021-12-03 http://hdl.handle.net/10138/337286 eng eng Multidisciplinary Digital Publishing Institute Aguilera-Correa, J.J.; Fernández-López, S.; Cuñas-Figueroa, I.D.; Pérez-Rial, S.; Alakomi, H.-L.; Nohynek, L.; Oksman-Caldentey, K.-M.; Salminen, J.-P.; Esteban, J.; Cuadros, J.; Puupponen-Pimiä, R.; Perez-Tanoira, R.; Kinnari, T.J. Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection. Antibiotics 2021, 10, 1481. http://hdl.handle.net/10138/337286 http://purl.org/eprint/entityType/JournalArticle http://purl.org/eprint/entityType/Expression 2021 ftunivhelsihelda 2022-11-02T23:58:26Z Staphylococcus aureus is the most common cause of surgical site infections and its treatment is challenging due to the emergence of multi-drug resistant strains such as methicillin-resistant S. aureus (MRSA). Natural berry-derived compounds have shown antimicrobial potential, e.g., ellagitannins such as sanguiin H-6 and lambertianin C, the main phenolic compounds in Rubus seeds, have shown antimicrobial activity. The aim of this study was to evaluate the effect of sanguiin H-6 and lambertianin C fractionated from cloudberry seeds, on the MRSA growth, and as treatment of a MRSA biofilm development in different growth media in vitro and in vivo by using a murine wound infection model where sanguiin H-6 and lambertianin C were used to prevent the MRSA infection. Sanguiin H-6 and lambertianin C inhibited the in vitro biofilm development and growth of MRSA. Furthermore, sanguiin H-6 showed significant anti-MRSA effect in the in vivo wound model. Our study shows the possible use of sanguiin H-6 as a preventive measure in surgical sites to avoid postoperative infections, whilst lambertianin C showed no anti-MRSA activity. Other/Unknown Material Rubus chamaemorus Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
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Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
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ftunivhelsihelda |
language |
English |
description |
Staphylococcus aureus is the most common cause of surgical site infections and its treatment is challenging due to the emergence of multi-drug resistant strains such as methicillin-resistant S. aureus (MRSA). Natural berry-derived compounds have shown antimicrobial potential, e.g., ellagitannins such as sanguiin H-6 and lambertianin C, the main phenolic compounds in Rubus seeds, have shown antimicrobial activity. The aim of this study was to evaluate the effect of sanguiin H-6 and lambertianin C fractionated from cloudberry seeds, on the MRSA growth, and as treatment of a MRSA biofilm development in different growth media in vitro and in vivo by using a murine wound infection model where sanguiin H-6 and lambertianin C were used to prevent the MRSA infection. Sanguiin H-6 and lambertianin C inhibited the in vitro biofilm development and growth of MRSA. Furthermore, sanguiin H-6 showed significant anti-MRSA effect in the in vivo wound model. Our study shows the possible use of sanguiin H-6 as a preventive measure in surgical sites to avoid postoperative infections, whilst lambertianin C showed no anti-MRSA activity. |
format |
Other/Unknown Material |
author |
Aguilera-Correa, John Jairo Fernández-López, Sara Cuñas-Figueroa, Iskra Dennisse Pérez-Rial, Sandra Alakomi, Hanna-Leena Nohynek, Liisa Oksman-Caldentey, Kirsi-Marja Salminen, Juha-Pekka Esteban, Jaime Cuadros, Juan Puupponen-Pimiä, Riitta Pérez-Tanoira, Ramón Kinnari, Teemu J. |
spellingShingle |
Aguilera-Correa, John Jairo Fernández-López, Sara Cuñas-Figueroa, Iskra Dennisse Pérez-Rial, Sandra Alakomi, Hanna-Leena Nohynek, Liisa Oksman-Caldentey, Kirsi-Marja Salminen, Juha-Pekka Esteban, Jaime Cuadros, Juan Puupponen-Pimiä, Riitta Pérez-Tanoira, Ramón Kinnari, Teemu J. Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection |
author_facet |
Aguilera-Correa, John Jairo Fernández-López, Sara Cuñas-Figueroa, Iskra Dennisse Pérez-Rial, Sandra Alakomi, Hanna-Leena Nohynek, Liisa Oksman-Caldentey, Kirsi-Marja Salminen, Juha-Pekka Esteban, Jaime Cuadros, Juan Puupponen-Pimiä, Riitta Pérez-Tanoira, Ramón Kinnari, Teemu J. |
author_sort |
Aguilera-Correa, John Jairo |
title |
Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection |
title_short |
Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection |
title_full |
Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection |
title_fullStr |
Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection |
title_full_unstemmed |
Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection |
title_sort |
sanguiin h-6 fractionated from cloudberry (rubus chamaemorus) seeds can prevent the methicillin-resistant staphylococcus aureus biofilm development during wound infection |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2021 |
url |
http://hdl.handle.net/10138/337286 |
genre |
Rubus chamaemorus |
genre_facet |
Rubus chamaemorus |
op_relation |
Aguilera-Correa, J.J.; Fernández-López, S.; Cuñas-Figueroa, I.D.; Pérez-Rial, S.; Alakomi, H.-L.; Nohynek, L.; Oksman-Caldentey, K.-M.; Salminen, J.-P.; Esteban, J.; Cuadros, J.; Puupponen-Pimiä, R.; Perez-Tanoira, R.; Kinnari, T.J. Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection. Antibiotics 2021, 10, 1481. http://hdl.handle.net/10138/337286 |
_version_ |
1766180012046680064 |