Maternal smoking during pregnancy affects adult onset of asthma in offspring : a follow up from birth to age 46 years
Rationale: Environmental tobacco smoke (ETS) exposure increases asthma risk in children. There is limited knowledge of prenatal ETS for adult-onset asthma. Objectives: To determine the association between prenatal ETS and adult onset asthma. Measurements and main results: The questionnaire and clini...
Published in: | European Respiratory Journal |
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Main Authors: | , , , , , , , |
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Format: | Article in Journal/Newspaper |
Language: | English |
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EUROPEAN RESPIRATORY SOC JOURNALS LTD
2021
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Online Access: | http://hdl.handle.net/10138/333865 |
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/333865 |
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Open Polar |
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HELDA – University of Helsinki Open Repository |
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ftunivhelsihelda |
language |
English |
topic |
ENVIRONMENTAL TOBACCO-SMOKE CHILDHOOD ASTHMA LUNG-FUNCTION PARENTAL SMOKING LSM PROTEINS IN-UTERO POPULATION EXPOSURE CHILDREN RISK 3121 General medicine internal medicine and other clinical medicine |
spellingShingle |
ENVIRONMENTAL TOBACCO-SMOKE CHILDHOOD ASTHMA LUNG-FUNCTION PARENTAL SMOKING LSM PROTEINS IN-UTERO POPULATION EXPOSURE CHILDREN RISK 3121 General medicine internal medicine and other clinical medicine Toppila-Salmi, Sanna Luukkainen, Annika T. Xu, Baizhuang Lampi, Jussi Auvinen, Juha Dhaygude, Kishor Järvelin, Marjo-Riitta Pekkanen, Juha Maternal smoking during pregnancy affects adult onset of asthma in offspring : a follow up from birth to age 46 years |
topic_facet |
ENVIRONMENTAL TOBACCO-SMOKE CHILDHOOD ASTHMA LUNG-FUNCTION PARENTAL SMOKING LSM PROTEINS IN-UTERO POPULATION EXPOSURE CHILDREN RISK 3121 General medicine internal medicine and other clinical medicine |
description |
Rationale: Environmental tobacco smoke (ETS) exposure increases asthma risk in children. There is limited knowledge of prenatal ETS for adult-onset asthma. Objectives: To determine the association between prenatal ETS and adult onset asthma. Measurements and main results: The questionnaire and clinical data of 5200 people, free of physician-diagnosed asthma by 31 years of age, who were included in the Northern Finland Birth Cohort 1966 Study was used. The association of maternal smoking during the last 3 months of pregnancy with onset of physician-diagnosed asthma and with lung function in adult offspring was studied using adjusted multivariate regression analyses. The cumulative incidence of physician-diagnosed asthma between the ages of 31 and 46 years was 5.1% among men and 8.8% among women. Gestational smoke exposure was associated with adult-onset asthma among offspring (adjusted OR 1.54, 95% CI 1.04-2.29), namely among offspring who reported either past non-diagnosed asthma (OR 9.63, 95% CI 2.28-40.67) or past cough with wheeze (3.21, 95% CI 1.71-6.05). A significant association was detected between gestational smoke exposure and the offspring's forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio at 31 years of age. In offspring with the haplotype rs11702779-AA of RUNX1, gestational smoke exposure was associated with adult-onset asthma (5.53, 95% CI 2.11-14.52, adjusted p-value for interaction 0.10). Conclusion: Maternal smoking during pregnancy is associated with the cumulative incidence of asthma in offspring between the ages of 31 and 46 years. The association was accentuated in offspring who at age 31, reported having past respiratory problems and/or who had haplotype rs11702779-AA. A reduction in FEV1/FVC ratio was also observed at age 31 years in offspring with gestational smoke exposure. These results could reflect the early vulnerability of offspring's airways to ETS and its putative long-term effects. Peer reviewed |
author2 |
HUS Inflammation Center Department of Pathology Department of Dermatology, Allergology and Venereology Medicum University of Helsinki Helsinki University Hospital Area Department of Public Health |
format |
Article in Journal/Newspaper |
author |
Toppila-Salmi, Sanna Luukkainen, Annika T. Xu, Baizhuang Lampi, Jussi Auvinen, Juha Dhaygude, Kishor Järvelin, Marjo-Riitta Pekkanen, Juha |
author_facet |
Toppila-Salmi, Sanna Luukkainen, Annika T. Xu, Baizhuang Lampi, Jussi Auvinen, Juha Dhaygude, Kishor Järvelin, Marjo-Riitta Pekkanen, Juha |
author_sort |
Toppila-Salmi, Sanna |
title |
Maternal smoking during pregnancy affects adult onset of asthma in offspring : a follow up from birth to age 46 years |
title_short |
Maternal smoking during pregnancy affects adult onset of asthma in offspring : a follow up from birth to age 46 years |
title_full |
Maternal smoking during pregnancy affects adult onset of asthma in offspring : a follow up from birth to age 46 years |
title_fullStr |
Maternal smoking during pregnancy affects adult onset of asthma in offspring : a follow up from birth to age 46 years |
title_full_unstemmed |
Maternal smoking during pregnancy affects adult onset of asthma in offspring : a follow up from birth to age 46 years |
title_sort |
maternal smoking during pregnancy affects adult onset of asthma in offspring : a follow up from birth to age 46 years |
publisher |
EUROPEAN RESPIRATORY SOC JOURNALS LTD |
publishDate |
2021 |
url |
http://hdl.handle.net/10138/333865 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
10.1183/13993003.01857-2019 The study was supported in part by research grants from the Finnish Society of Allergology and Immunology, the Jane and Aatos Erkko Foundation, the Finnish Cultural Foundation, State funding for university-level health research (TYH2018103, TYH2019322), Paulo Foundation, the Tampere Tuberculosis Foundation, the Vaino and Laina Kivi Foundation. Funding information for this article has been deposited with the Crossref Funder Registry. Toppila-Salmi , S , Luukkainen , A T , Xu , B , Lampi , J , Auvinen , J , Dhaygude , K , Järvelin , M-R & Pekkanen , J 2020 , ' Maternal smoking during pregnancy affects adult onset of asthma in offspring : a follow up from birth to age 46 years ' , European Respiratory Journal , vol. 55 , no. 6 , 1901857 . https://doi.org/10.1183/13993003.01857-2019 ORCID: /0000-0003-0890-6686/work/79519434 ORCID: /0000-0003-4499-6180/work/79519505 ORCID: /0000-0002-1083-8777/work/150722614 783f2b71-b6eb-46b4-86e4-7d1e86c60fa8 http://hdl.handle.net/10138/333865 000548160000044 |
op_rights |
openAccess info:eu-repo/semantics/openAccess |
container_title |
European Respiratory Journal |
container_volume |
55 |
container_issue |
6 |
container_start_page |
1901857 |
_version_ |
1790605269719318528 |
spelling |
ftunivhelsihelda:oai:helda.helsinki.fi:10138/333865 2024-02-11T10:07:07+01:00 Maternal smoking during pregnancy affects adult onset of asthma in offspring : a follow up from birth to age 46 years Toppila-Salmi, Sanna Luukkainen, Annika T. Xu, Baizhuang Lampi, Jussi Auvinen, Juha Dhaygude, Kishor Järvelin, Marjo-Riitta Pekkanen, Juha HUS Inflammation Center Department of Pathology Department of Dermatology, Allergology and Venereology Medicum University of Helsinki Helsinki University Hospital Area Department of Public Health 2021-08-31T22:06:39Z 11 application/pdf http://hdl.handle.net/10138/333865 eng eng EUROPEAN RESPIRATORY SOC JOURNALS LTD 10.1183/13993003.01857-2019 The study was supported in part by research grants from the Finnish Society of Allergology and Immunology, the Jane and Aatos Erkko Foundation, the Finnish Cultural Foundation, State funding for university-level health research (TYH2018103, TYH2019322), Paulo Foundation, the Tampere Tuberculosis Foundation, the Vaino and Laina Kivi Foundation. Funding information for this article has been deposited with the Crossref Funder Registry. Toppila-Salmi , S , Luukkainen , A T , Xu , B , Lampi , J , Auvinen , J , Dhaygude , K , Järvelin , M-R & Pekkanen , J 2020 , ' Maternal smoking during pregnancy affects adult onset of asthma in offspring : a follow up from birth to age 46 years ' , European Respiratory Journal , vol. 55 , no. 6 , 1901857 . https://doi.org/10.1183/13993003.01857-2019 ORCID: /0000-0003-0890-6686/work/79519434 ORCID: /0000-0003-4499-6180/work/79519505 ORCID: /0000-0002-1083-8777/work/150722614 783f2b71-b6eb-46b4-86e4-7d1e86c60fa8 http://hdl.handle.net/10138/333865 000548160000044 openAccess info:eu-repo/semantics/openAccess ENVIRONMENTAL TOBACCO-SMOKE CHILDHOOD ASTHMA LUNG-FUNCTION PARENTAL SMOKING LSM PROTEINS IN-UTERO POPULATION EXPOSURE CHILDREN RISK 3121 General medicine internal medicine and other clinical medicine Article acceptedVersion 2021 ftunivhelsihelda 2024-01-18T00:01:14Z Rationale: Environmental tobacco smoke (ETS) exposure increases asthma risk in children. There is limited knowledge of prenatal ETS for adult-onset asthma. Objectives: To determine the association between prenatal ETS and adult onset asthma. Measurements and main results: The questionnaire and clinical data of 5200 people, free of physician-diagnosed asthma by 31 years of age, who were included in the Northern Finland Birth Cohort 1966 Study was used. The association of maternal smoking during the last 3 months of pregnancy with onset of physician-diagnosed asthma and with lung function in adult offspring was studied using adjusted multivariate regression analyses. The cumulative incidence of physician-diagnosed asthma between the ages of 31 and 46 years was 5.1% among men and 8.8% among women. Gestational smoke exposure was associated with adult-onset asthma among offspring (adjusted OR 1.54, 95% CI 1.04-2.29), namely among offspring who reported either past non-diagnosed asthma (OR 9.63, 95% CI 2.28-40.67) or past cough with wheeze (3.21, 95% CI 1.71-6.05). A significant association was detected between gestational smoke exposure and the offspring's forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio at 31 years of age. In offspring with the haplotype rs11702779-AA of RUNX1, gestational smoke exposure was associated with adult-onset asthma (5.53, 95% CI 2.11-14.52, adjusted p-value for interaction 0.10). Conclusion: Maternal smoking during pregnancy is associated with the cumulative incidence of asthma in offspring between the ages of 31 and 46 years. The association was accentuated in offspring who at age 31, reported having past respiratory problems and/or who had haplotype rs11702779-AA. A reduction in FEV1/FVC ratio was also observed at age 31 years in offspring with gestational smoke exposure. These results could reflect the early vulnerability of offspring's airways to ETS and its putative long-term effects. Peer reviewed Article in Journal/Newspaper Northern Finland HELDA – University of Helsinki Open Repository European Respiratory Journal 55 6 1901857 |