Preimplantation genetic testing legislation and accessibility in the Nordic countries
Abstract Introduction Assisted Reproduction Technologies are in rapid development and implementation of preimplantation genetic testing (PGT) has allowed patients with genetic disorders to initiate pregnancies while minimizing or eliminating the risk of transmitting these disorders to their offsprin...
Published in: | Acta Obstetricia et Gynecologica Scandinavica |
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/327100 2024-01-07T09:44:17+01:00 Preimplantation genetic testing legislation and accessibility in the Nordic countries Hreinsson, Julius Lundin, Kersti Iwarsson, Erik Hausken, Jon Einarsson, Snorri Grøndahl, Marie Louise Hydén-Granskog, Christel Ingerslev, Hans Jakob HUS Helsinki and Uusimaa Hospital District Clinicum 2021-02-25T22:58:44Z 6 application/pdf http://hdl.handle.net/10138/327100 eng eng Wiley 10.1111/aogs.13831 Hreinsson , J , Lundin , K , Iwarsson , E , Hausken , J , Einarsson , S , Grøndahl , M L , Hydén-Granskog , C & Ingerslev , H J 2020 , ' Preimplantation genetic testing legislation and accessibility in the Nordic countries ' , Acta Obstetricia et Gynecologica Scandinavica , vol. 99 , no. 6 , pp. 716-721 . https://doi.org/10.1111/aogs.13831 RIS: urn:055B16883FDF912C1D59A5BBD39D13CA fa6dba2c-b807-4234-b1bb-6b8a6958498a http://hdl.handle.net/10138/327100 000535323400005 unspecified openAccess info:eu-repo/semantics/openAccess aneuploidies assisted reproductive technologies Legislation in ART monogenic disorders Nordic PGT legislation preimplantation genetic testing structural rearrangements DIAGNOSIS preimplantation genetic testing legislation legislation in assisted reproductive technologies ANEUPLOIDY DNA AGE 3123 Gynaecology and paediatrics Article acceptedVersion 2021 ftunivhelsihelda 2023-12-14T00:10:36Z Abstract Introduction Assisted Reproduction Technologies are in rapid development and implementation of preimplantation genetic testing (PGT) has allowed patients with genetic disorders to initiate pregnancies while minimizing or eliminating the risk of transmitting these disorders to their offspring. Testing for numeric chromosomal anomalies has been proposed as a way to increase efficacy in assisted reproduction, however this remains disputed. Legislation is lagging behind the rapid developments in this field. Material and methods We conducted a structured online survey of legislation and accessibility to Preimplantation Genetic Testing in the Nordic countries to compare the regulation and uptake of this technique. The survey was designed and answered by the authors. Results Key elements in regulation of preimplantation testing for monogenic disorders and structural rearrangements are similar in the Nordic countries although accessibility varies since only Denmark, Finland and Sweden have national clinics offering treatment. In addition, Denmark and Finland have private clinics offering PGT. Regulation is most stringent in Norway where a national board evaluates all couples seeking treatment. Treatment volumes vary between the Nordic countries with Norway and Finland having lowest treatment numbers. Preimplantation genetic testing for aneuploidy in the embryo varies between the Nordic countries where Finland and Iceland are allowed to offer this form of treatment, Denmark and Sweden only in the form of a research protocol while this form of testing is not allowed at all in Norway. Therefore the number of treatment cycles involving testing for embryo aneuploidy are lower in the Nordic countries compared to other countries where this treatment option is more common. Conclusions Science needs to inform politics regarding the rapidly evolving field of reproductive medicine and we recommend harmonization of legislation and accessibility between the Nordic countries. Peer reviewed Article in Journal/Newspaper Iceland HELDA – University of Helsinki Open Repository Norway Acta Obstetricia et Gynecologica Scandinavica 99 6 716 721 |
institution |
Open Polar |
collection |
HELDA – University of Helsinki Open Repository |
op_collection_id |
ftunivhelsihelda |
language |
English |
topic |
aneuploidies assisted reproductive technologies Legislation in ART monogenic disorders Nordic PGT legislation preimplantation genetic testing structural rearrangements DIAGNOSIS preimplantation genetic testing legislation legislation in assisted reproductive technologies ANEUPLOIDY DNA AGE 3123 Gynaecology and paediatrics |
spellingShingle |
aneuploidies assisted reproductive technologies Legislation in ART monogenic disorders Nordic PGT legislation preimplantation genetic testing structural rearrangements DIAGNOSIS preimplantation genetic testing legislation legislation in assisted reproductive technologies ANEUPLOIDY DNA AGE 3123 Gynaecology and paediatrics Hreinsson, Julius Lundin, Kersti Iwarsson, Erik Hausken, Jon Einarsson, Snorri Grøndahl, Marie Louise Hydén-Granskog, Christel Ingerslev, Hans Jakob Preimplantation genetic testing legislation and accessibility in the Nordic countries |
topic_facet |
aneuploidies assisted reproductive technologies Legislation in ART monogenic disorders Nordic PGT legislation preimplantation genetic testing structural rearrangements DIAGNOSIS preimplantation genetic testing legislation legislation in assisted reproductive technologies ANEUPLOIDY DNA AGE 3123 Gynaecology and paediatrics |
description |
Abstract Introduction Assisted Reproduction Technologies are in rapid development and implementation of preimplantation genetic testing (PGT) has allowed patients with genetic disorders to initiate pregnancies while minimizing or eliminating the risk of transmitting these disorders to their offspring. Testing for numeric chromosomal anomalies has been proposed as a way to increase efficacy in assisted reproduction, however this remains disputed. Legislation is lagging behind the rapid developments in this field. Material and methods We conducted a structured online survey of legislation and accessibility to Preimplantation Genetic Testing in the Nordic countries to compare the regulation and uptake of this technique. The survey was designed and answered by the authors. Results Key elements in regulation of preimplantation testing for monogenic disorders and structural rearrangements are similar in the Nordic countries although accessibility varies since only Denmark, Finland and Sweden have national clinics offering treatment. In addition, Denmark and Finland have private clinics offering PGT. Regulation is most stringent in Norway where a national board evaluates all couples seeking treatment. Treatment volumes vary between the Nordic countries with Norway and Finland having lowest treatment numbers. Preimplantation genetic testing for aneuploidy in the embryo varies between the Nordic countries where Finland and Iceland are allowed to offer this form of treatment, Denmark and Sweden only in the form of a research protocol while this form of testing is not allowed at all in Norway. Therefore the number of treatment cycles involving testing for embryo aneuploidy are lower in the Nordic countries compared to other countries where this treatment option is more common. Conclusions Science needs to inform politics regarding the rapidly evolving field of reproductive medicine and we recommend harmonization of legislation and accessibility between the Nordic countries. Peer reviewed |
author2 |
HUS Helsinki and Uusimaa Hospital District Clinicum |
format |
Article in Journal/Newspaper |
author |
Hreinsson, Julius Lundin, Kersti Iwarsson, Erik Hausken, Jon Einarsson, Snorri Grøndahl, Marie Louise Hydén-Granskog, Christel Ingerslev, Hans Jakob |
author_facet |
Hreinsson, Julius Lundin, Kersti Iwarsson, Erik Hausken, Jon Einarsson, Snorri Grøndahl, Marie Louise Hydén-Granskog, Christel Ingerslev, Hans Jakob |
author_sort |
Hreinsson, Julius |
title |
Preimplantation genetic testing legislation and accessibility in the Nordic countries |
title_short |
Preimplantation genetic testing legislation and accessibility in the Nordic countries |
title_full |
Preimplantation genetic testing legislation and accessibility in the Nordic countries |
title_fullStr |
Preimplantation genetic testing legislation and accessibility in the Nordic countries |
title_full_unstemmed |
Preimplantation genetic testing legislation and accessibility in the Nordic countries |
title_sort |
preimplantation genetic testing legislation and accessibility in the nordic countries |
publisher |
Wiley |
publishDate |
2021 |
url |
http://hdl.handle.net/10138/327100 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
10.1111/aogs.13831 Hreinsson , J , Lundin , K , Iwarsson , E , Hausken , J , Einarsson , S , Grøndahl , M L , Hydén-Granskog , C & Ingerslev , H J 2020 , ' Preimplantation genetic testing legislation and accessibility in the Nordic countries ' , Acta Obstetricia et Gynecologica Scandinavica , vol. 99 , no. 6 , pp. 716-721 . https://doi.org/10.1111/aogs.13831 RIS: urn:055B16883FDF912C1D59A5BBD39D13CA fa6dba2c-b807-4234-b1bb-6b8a6958498a http://hdl.handle.net/10138/327100 000535323400005 |
op_rights |
unspecified openAccess info:eu-repo/semantics/openAccess |
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Acta Obstetricia et Gynecologica Scandinavica |
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99 |
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6 |
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