Prevalence of oral mucosal normal variations and lesions in a middle-aged population : a Northern Finland Birth Cohort 1966 study
Background In this cross-sectional study we investigated the oral mucosal changes in a middle-aged Finnish population. We analyzed the prevalence of potentially malignant disorders and the influence of smoking, snuff and alcohol use on the mucosal changes. Methods Of the 12,068 members of the NFBC 1...
Published in: | BMC Oral Health |
---|---|
Main Authors: | , , , , |
Other Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BioMed Central Ltd
2021
|
Subjects: | |
Online Access: | http://hdl.handle.net/10138/324537 |
id |
ftunivhelsihelda:oai:helda.helsinki.fi:10138/324537 |
---|---|
record_format |
openpolar |
spelling |
ftunivhelsihelda:oai:helda.helsinki.fi:10138/324537 2024-01-07T09:45:27+01:00 Prevalence of oral mucosal normal variations and lesions in a middle-aged population : a Northern Finland Birth Cohort 1966 study Oivio, Ulla-Maija Pesonen, Paula Ylipalosaari, Merja Kullaa, Arja Salo, Tuula HUSLAB Department of Oral and Maxillofacial Diseases University of Helsinki Department of Pathology Helsinki University Hospital Area 2021-01-14T12:13:01Z 9 application/pdf http://hdl.handle.net/10138/324537 eng eng BioMed Central Ltd 10.1186/s12903-020-01351-9 NFBC1966 receives financial assistance from University of Oulu Grant no. 24000692, Oulu University Hospital Grant no. 24301140, ERDF European Regional Development Fund Grant No. 539/2010 A31592. This study did not have any financial support. Oivio , U-M , Pesonen , P , Ylipalosaari , M , Kullaa , A & Salo , T 2020 , ' Prevalence of oral mucosal normal variations and lesions in a middle-aged population : a Northern Finland Birth Cohort 1966 study ' , BMC Oral Health , vol. 20 , no. 1 , 357 . https://doi.org/10.1186/s12903-020-01351-9 ORCID: /0000-0001-6039-0088/work/86937890 3ba58fb0-ed46-4bd5-9e35-114f630ff384 http://hdl.handle.net/10138/324537 000600107100002 cc_by openAccess info:eu-repo/semantics/openAccess NFBC Cross-sectional study Middle-aged population Oral mucosa Normal variations and lesions Oral lichen planus Oral lichenoid reaction Prevalence Leukoplakia LICHEN-PLANUS WHITE LESIONS HABITS 313 Dentistry Article publishedVersion 2021 ftunivhelsihelda 2023-12-14T00:13:20Z Background In this cross-sectional study we investigated the oral mucosal changes in a middle-aged Finnish population. We analyzed the prevalence of potentially malignant disorders and the influence of smoking, snuff and alcohol use on the mucosal changes. Methods Of the 12,068 members of the NFBC 1966, a total of 1961 participants (16.2%) constituted the study population. Mucosal changes were diagnosed and photographed by seven general dentists, and two specialists re-analyzed all the diagnoses based on the documentation Cross-tabulation with Chi-square tests and logistic regression analysis were used to analyze the data. Results Of the participants, 10.5% had some mucosal changes, of which 81.8% were diagnosed as oral mucosal lesions (OML) and 18.2% as normal variations. Of the normal variations, the most common were Fordyce granules (1.2%), fissured tongue (1.1%) and geographic tongue (0.9%). The most common OMLs were white lesions (6.5%), of which oral lichen planus (OLP) and lichenoid reactions (OLR), grouped as oral lichenoid diseases, were present in 3.5%, males more often (3.8% vs. 3.1%). OLP was found in 1.5% of all participants, females more often (1.8% vs. 1.2%), while OLR was more common in males (2.7% vs. 1.3%). Leukoplakia was identified in 0.5% of the population; twice more often in males (0.6% vs. 0.3%). Erythroplakia was not found. Current smokers had higher risk for oral mucosal changes than former or non-smokers (OR 3.0, 95% CI 2.11-4.28), and snuff, used occasionally or regularly, also raised the risk (OR 2.6, 95% CI 1.48-4.70). Conclusions In the middle-aged northern Finland population, 4% of OMLs were potentially malignant disorders, including OLR (2%), OLP (1.5%) and leukoplakia (0.5%). In particular, smoking and snuff use increased the risk for having any oral mucosa changes. Peer reviewed Article in Journal/Newspaper Northern Finland HELDA – University of Helsinki Open Repository BMC Oral Health 20 1 |
institution |
Open Polar |
collection |
HELDA – University of Helsinki Open Repository |
op_collection_id |
ftunivhelsihelda |
language |
English |
topic |
NFBC Cross-sectional study Middle-aged population Oral mucosa Normal variations and lesions Oral lichen planus Oral lichenoid reaction Prevalence Leukoplakia LICHEN-PLANUS WHITE LESIONS HABITS 313 Dentistry |
spellingShingle |
NFBC Cross-sectional study Middle-aged population Oral mucosa Normal variations and lesions Oral lichen planus Oral lichenoid reaction Prevalence Leukoplakia LICHEN-PLANUS WHITE LESIONS HABITS 313 Dentistry Oivio, Ulla-Maija Pesonen, Paula Ylipalosaari, Merja Kullaa, Arja Salo, Tuula Prevalence of oral mucosal normal variations and lesions in a middle-aged population : a Northern Finland Birth Cohort 1966 study |
topic_facet |
NFBC Cross-sectional study Middle-aged population Oral mucosa Normal variations and lesions Oral lichen planus Oral lichenoid reaction Prevalence Leukoplakia LICHEN-PLANUS WHITE LESIONS HABITS 313 Dentistry |
description |
Background In this cross-sectional study we investigated the oral mucosal changes in a middle-aged Finnish population. We analyzed the prevalence of potentially malignant disorders and the influence of smoking, snuff and alcohol use on the mucosal changes. Methods Of the 12,068 members of the NFBC 1966, a total of 1961 participants (16.2%) constituted the study population. Mucosal changes were diagnosed and photographed by seven general dentists, and two specialists re-analyzed all the diagnoses based on the documentation Cross-tabulation with Chi-square tests and logistic regression analysis were used to analyze the data. Results Of the participants, 10.5% had some mucosal changes, of which 81.8% were diagnosed as oral mucosal lesions (OML) and 18.2% as normal variations. Of the normal variations, the most common were Fordyce granules (1.2%), fissured tongue (1.1%) and geographic tongue (0.9%). The most common OMLs were white lesions (6.5%), of which oral lichen planus (OLP) and lichenoid reactions (OLR), grouped as oral lichenoid diseases, were present in 3.5%, males more often (3.8% vs. 3.1%). OLP was found in 1.5% of all participants, females more often (1.8% vs. 1.2%), while OLR was more common in males (2.7% vs. 1.3%). Leukoplakia was identified in 0.5% of the population; twice more often in males (0.6% vs. 0.3%). Erythroplakia was not found. Current smokers had higher risk for oral mucosal changes than former or non-smokers (OR 3.0, 95% CI 2.11-4.28), and snuff, used occasionally or regularly, also raised the risk (OR 2.6, 95% CI 1.48-4.70). Conclusions In the middle-aged northern Finland population, 4% of OMLs were potentially malignant disorders, including OLR (2%), OLP (1.5%) and leukoplakia (0.5%). In particular, smoking and snuff use increased the risk for having any oral mucosa changes. Peer reviewed |
author2 |
HUSLAB Department of Oral and Maxillofacial Diseases University of Helsinki Department of Pathology Helsinki University Hospital Area |
format |
Article in Journal/Newspaper |
author |
Oivio, Ulla-Maija Pesonen, Paula Ylipalosaari, Merja Kullaa, Arja Salo, Tuula |
author_facet |
Oivio, Ulla-Maija Pesonen, Paula Ylipalosaari, Merja Kullaa, Arja Salo, Tuula |
author_sort |
Oivio, Ulla-Maija |
title |
Prevalence of oral mucosal normal variations and lesions in a middle-aged population : a Northern Finland Birth Cohort 1966 study |
title_short |
Prevalence of oral mucosal normal variations and lesions in a middle-aged population : a Northern Finland Birth Cohort 1966 study |
title_full |
Prevalence of oral mucosal normal variations and lesions in a middle-aged population : a Northern Finland Birth Cohort 1966 study |
title_fullStr |
Prevalence of oral mucosal normal variations and lesions in a middle-aged population : a Northern Finland Birth Cohort 1966 study |
title_full_unstemmed |
Prevalence of oral mucosal normal variations and lesions in a middle-aged population : a Northern Finland Birth Cohort 1966 study |
title_sort |
prevalence of oral mucosal normal variations and lesions in a middle-aged population : a northern finland birth cohort 1966 study |
publisher |
BioMed Central Ltd |
publishDate |
2021 |
url |
http://hdl.handle.net/10138/324537 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
10.1186/s12903-020-01351-9 NFBC1966 receives financial assistance from University of Oulu Grant no. 24000692, Oulu University Hospital Grant no. 24301140, ERDF European Regional Development Fund Grant No. 539/2010 A31592. This study did not have any financial support. Oivio , U-M , Pesonen , P , Ylipalosaari , M , Kullaa , A & Salo , T 2020 , ' Prevalence of oral mucosal normal variations and lesions in a middle-aged population : a Northern Finland Birth Cohort 1966 study ' , BMC Oral Health , vol. 20 , no. 1 , 357 . https://doi.org/10.1186/s12903-020-01351-9 ORCID: /0000-0001-6039-0088/work/86937890 3ba58fb0-ed46-4bd5-9e35-114f630ff384 http://hdl.handle.net/10138/324537 000600107100002 |
op_rights |
cc_by openAccess info:eu-repo/semantics/openAccess |
container_title |
BMC Oral Health |
container_volume |
20 |
container_issue |
1 |
_version_ |
1787426991381676032 |