Early-life infections, medications, and atopic sensitization in the development of immune-mediated diseases in Finland, Estonia, and Russian Karelia
Background: The incidence of immune-mediated diseases, such as type 1 diabetes (T1D), celiac disease (CD), and allergic diseases, has been increasing since the 1950s. This trend has been particularly conspicuous in affluent Westernized countries. Etiologies behind these diseases are still poorly und...
Main Author: | |
---|---|
Other Authors: | , , , , , , , , , |
Format: | Doctoral or Postdoctoral Thesis |
Language: | English |
Published: |
Helsingin yliopisto
2020
|
Subjects: | |
Online Access: | http://hdl.handle.net/10138/320993 |
id |
ftunivhelsihelda:oai:helda.helsinki.fi:10138/320993 |
---|---|
record_format |
openpolar |
spelling |
ftunivhelsihelda:oai:helda.helsinki.fi:10138/320993 2024-09-15T18:16:13+00:00 Early-life infections, medications, and atopic sensitization in the development of immune-mediated diseases in Finland, Estonia, and Russian Karelia Lapsuudenajan infektiot ja niiden yhteys allergisiin- ja immuunisairauksiin Suomessa, Virossa ja Venäjän Karjalassa Mustonen, Neea University of Helsinki, Faculty of Medicine, Research Program for Clinical and Molecular Metabolism Doctoral Program in Clinical Research Children’s Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital Helsingin yliopisto, lääketieteellinen tiedekunta Kliininen tohtoriohjelma Helsingfors universitet, medicinska fakulteten Doktorandprogrammet i klinisk forskning Almqvist Malmros, Catarina Knip, Mikael Siljander, Heli 2020-11-02T05:33:17Z application/pdf http://hdl.handle.net/10138/320993 eng eng Helsingin yliopisto Helsingfors universitet University of Helsinki URN:ISBN:978-951-51-6672-2 Unigrafia, Helsinki: 2020, Dissertationes Scholae Doctoralis Ad Sanitatem Investigandam Universitatis Helsinkiensis. 2342-3161 Dissertationes Scholae Doctoralis Ad Sanitatem Investigandam Universitatis Helsinkiensis URN:ISSN:2342-317X http://hdl.handle.net/10138/320993 URN:ISBN:978-951-51-6673-9 Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty. This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited. Publikationen är skyddad av upphovsrätten. Den får läsas och skrivas ut för personligt bruk. Användning i kommersiellt syfte är förbjuden. lääketieteellinen tiedekunta Doctoral dissertation (article-based) Artikkeliväitöskirja Artikelavhandling Text doctoralThesis 2020 ftunivhelsihelda 2024-07-04T04:52:39Z Background: The incidence of immune-mediated diseases, such as type 1 diabetes (T1D), celiac disease (CD), and allergic diseases, has been increasing since the 1950s. This trend has been particularly conspicuous in affluent Westernized countries. Etiologies behind these diseases are still poorly understood, but socioeconomic circumstances and environmental factors may play a crucial role in their pathomechanisms. The hygiene hypothesis aims to explain the rising trend in immune-mediated diseases by suggesting that children’s developing immune systems are vulnerable to malfunction in environments that provide inadequate microbial exposure early in life. Aims: This thesis aims to explore how early clinical infections, their medications, and allergic sensitization associate with the development of T1D, CD, and allergies in three geographically close areas in Finland, Estonia, and Russian Karelia. These neighboring countries have shown clear contrasts in the frequencies of immune-mediated diseases, standards of hygiene, and socioeconomic circumstances. Methods: As part of the DIABIMMUNE study, over 4500 children from Finland, Estonia, and Russian Karelia were prospectively followed either from birth to 3 years of age or from 3 to 5 years of age. Children attended regular clinical visits that comprised physical examinations and the collection of biological samples for the assessment of immune-mediated outcomes. Children’s parents prospectively reported all participating children’s illnesses, infections, medications, and allergic symptoms that appeared during the follow-up. Results: Regarding infectious illnesses, respiratory infections were most frequently reported, followed by gastrointestinal infections, unlocalized febrile episodes, and other localized infections. Compared to Russian Karelian and Estonian children, Finnish children experienced more infections and used more medications. Finnish children also had the highest frequency of T1D, CD, and allergic sensitization. In all, progression to T1D was associated ... Doctoral or Postdoctoral Thesis karelia* karelian HELDA – University of Helsinki Open Repository |
institution |
Open Polar |
collection |
HELDA – University of Helsinki Open Repository |
op_collection_id |
ftunivhelsihelda |
language |
English |
topic |
lääketieteellinen tiedekunta |
spellingShingle |
lääketieteellinen tiedekunta Mustonen, Neea Early-life infections, medications, and atopic sensitization in the development of immune-mediated diseases in Finland, Estonia, and Russian Karelia |
topic_facet |
lääketieteellinen tiedekunta |
description |
Background: The incidence of immune-mediated diseases, such as type 1 diabetes (T1D), celiac disease (CD), and allergic diseases, has been increasing since the 1950s. This trend has been particularly conspicuous in affluent Westernized countries. Etiologies behind these diseases are still poorly understood, but socioeconomic circumstances and environmental factors may play a crucial role in their pathomechanisms. The hygiene hypothesis aims to explain the rising trend in immune-mediated diseases by suggesting that children’s developing immune systems are vulnerable to malfunction in environments that provide inadequate microbial exposure early in life. Aims: This thesis aims to explore how early clinical infections, their medications, and allergic sensitization associate with the development of T1D, CD, and allergies in three geographically close areas in Finland, Estonia, and Russian Karelia. These neighboring countries have shown clear contrasts in the frequencies of immune-mediated diseases, standards of hygiene, and socioeconomic circumstances. Methods: As part of the DIABIMMUNE study, over 4500 children from Finland, Estonia, and Russian Karelia were prospectively followed either from birth to 3 years of age or from 3 to 5 years of age. Children attended regular clinical visits that comprised physical examinations and the collection of biological samples for the assessment of immune-mediated outcomes. Children’s parents prospectively reported all participating children’s illnesses, infections, medications, and allergic symptoms that appeared during the follow-up. Results: Regarding infectious illnesses, respiratory infections were most frequently reported, followed by gastrointestinal infections, unlocalized febrile episodes, and other localized infections. Compared to Russian Karelian and Estonian children, Finnish children experienced more infections and used more medications. Finnish children also had the highest frequency of T1D, CD, and allergic sensitization. In all, progression to T1D was associated ... |
author2 |
University of Helsinki, Faculty of Medicine, Research Program for Clinical and Molecular Metabolism Doctoral Program in Clinical Research Children’s Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital Helsingin yliopisto, lääketieteellinen tiedekunta Kliininen tohtoriohjelma Helsingfors universitet, medicinska fakulteten Doktorandprogrammet i klinisk forskning Almqvist Malmros, Catarina Knip, Mikael Siljander, Heli |
format |
Doctoral or Postdoctoral Thesis |
author |
Mustonen, Neea |
author_facet |
Mustonen, Neea |
author_sort |
Mustonen, Neea |
title |
Early-life infections, medications, and atopic sensitization in the development of immune-mediated diseases in Finland, Estonia, and Russian Karelia |
title_short |
Early-life infections, medications, and atopic sensitization in the development of immune-mediated diseases in Finland, Estonia, and Russian Karelia |
title_full |
Early-life infections, medications, and atopic sensitization in the development of immune-mediated diseases in Finland, Estonia, and Russian Karelia |
title_fullStr |
Early-life infections, medications, and atopic sensitization in the development of immune-mediated diseases in Finland, Estonia, and Russian Karelia |
title_full_unstemmed |
Early-life infections, medications, and atopic sensitization in the development of immune-mediated diseases in Finland, Estonia, and Russian Karelia |
title_sort |
early-life infections, medications, and atopic sensitization in the development of immune-mediated diseases in finland, estonia, and russian karelia |
publisher |
Helsingin yliopisto |
publishDate |
2020 |
url |
http://hdl.handle.net/10138/320993 |
genre |
karelia* karelian |
genre_facet |
karelia* karelian |
op_relation |
URN:ISBN:978-951-51-6672-2 Unigrafia, Helsinki: 2020, Dissertationes Scholae Doctoralis Ad Sanitatem Investigandam Universitatis Helsinkiensis. 2342-3161 Dissertationes Scholae Doctoralis Ad Sanitatem Investigandam Universitatis Helsinkiensis URN:ISSN:2342-317X http://hdl.handle.net/10138/320993 URN:ISBN:978-951-51-6673-9 |
op_rights |
Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty. This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited. Publikationen är skyddad av upphovsrätten. Den får läsas och skrivas ut för personligt bruk. Användning i kommersiellt syfte är förbjuden. |
_version_ |
1810454229788131328 |