Administration of aromatase inhibitor MPV-2213ad to blue fox vixens (Vulpes lagopus) as a model for contraception in female dogs
The interest in non-surgical approaches to contraception and fertility control in female dogs has increased in recent years. In this study the effect of an aromatase inhibitor (finrozole) was evaluated in fur production animals, farmed blue fox vixens, as a model for contraception in bitches. A tota...
Published in: | Theriogenology |
---|---|
Main Authors: | , , , , , , , |
Other Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
2020
|
Subjects: | |
Online Access: | http://hdl.handle.net/10138/318028 |
id |
ftunivhelsihelda:oai:helda.helsinki.fi:10138/318028 |
---|---|
record_format |
openpolar |
spelling |
ftunivhelsihelda:oai:helda.helsinki.fi:10138/318028 2024-01-07T09:38:09+01:00 Administration of aromatase inhibitor MPV-2213ad to blue fox vixens (Vulpes lagopus) as a model for contraception in female dogs Lindh, Lena Lindeberg, H. Banting, A Banting, S. Sainmaa, S. Beasley, S. Korhonen, H. Peltoniemi, Olli Animal Reproduction Science Production Animal Medicine 2020-07-30T10:04:01Z 11 application/pdf http://hdl.handle.net/10138/318028 eng eng EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC 10.1016/j.theriogenology.2020.04.009 Lindh , L , Lindeberg , H , Banting , A , Banting , S , Sainmaa , S , Beasley , S , Korhonen , H & Peltoniemi , O 2020 , ' Administration of aromatase inhibitor MPV-2213ad to blue fox vixens (Vulpes lagopus) as a model for contraception in female dogs ' , Theriogenology , vol. 152 , pp. 53-63 . https://doi.org/10.1016/j.theriogenology.2020.04.009 ORCID: /0000-0002-9481-1837/work/78162561 bb56380a-350d-4ad3-99de-bb9477e37100 http://hdl.handle.net/10138/318028 000538937500007 cc_by_nc_nd openAccess info:eu-repo/semantics/openAccess ALOPEX-LAGOPUS Dog FERTILITY Fertility control Finrozole Fur bearing animal INSEMINATION OOCYTE MATURATION OVARIAN-FUNCTION Oestrus inhibition PERIPHERAL PLASMA PLASMA PROGESTERONE PREGNANCY PRO-ESTRUS REPRODUCTIVE SUCCESS 413 Veterinary science Article publishedVersion 2020 ftunivhelsihelda 2023-12-14T00:04:14Z The interest in non-surgical approaches to contraception and fertility control in female dogs has increased in recent years. In this study the effect of an aromatase inhibitor (finrozole) was evaluated in fur production animals, farmed blue fox vixens, as a model for contraception in bitches. A total of 80 vixens were divided into 4 groups, receiving orally placebo (A) or finrozole 0.5 mg/kg (B), 3.5 mg/kg (C) or 24.5 mg/kg (D) for 21 consecutive days beginning in the pre-ovulatory period of heat. Monitoring of the vixens included clinical signs of heat, measurement of vaginal electrical resistance (VER) as well as oestradiol and progesterone concentrations in plasma. The approximate relation of the start of treatment to ovulation varied from 11 days before to one day after ovulation provided that the LH peak occurred 0.5 -2 days before the VER peak and ovulation was then estimated to occur 2 days after the LH peak. Seventy vixens were artificially inseminated within 8 h after a 50 Omega decline in vaginal electrical resistance was detected. Ten vixens were not inseminated. Pregnancy was confirmed by transabdominal ultrasound examination and birth of cubs was recorded. The pregnancy rates in the groups were 89.5% (A), 81.3% (B), 55.6% (C) and 52.9% (D). The average number of live born pups in the four groups was 9.4 (A), 7.0 (B), 5.8 (C), and 3.8 (D), respectively. No deleterious effects (for instance malformations) of finrozole on pups could be verified. The administration of finrozole did not have a significant effect on oestradiol parameters and VER values in vixens. Progesterone values were significantly higher in treatment groups compared with the placebo group. The results indicate that pregnancy could be avoided by finrozole provided that doses of >= 3.5 mg/kg were used and the treatment was initiated at least four days before the day of artificial insemination. This corresponds with two to six days before ovulation provided that the LH peak occurred 0.5-2 days before the VER peak and that ovulation ... Article in Journal/Newspaper Alopex lagopus Vulpes lagopus HELDA – University of Helsinki Open Repository Theriogenology 152 53 63 |
institution |
Open Polar |
collection |
HELDA – University of Helsinki Open Repository |
op_collection_id |
ftunivhelsihelda |
language |
English |
topic |
ALOPEX-LAGOPUS Dog FERTILITY Fertility control Finrozole Fur bearing animal INSEMINATION OOCYTE MATURATION OVARIAN-FUNCTION Oestrus inhibition PERIPHERAL PLASMA PLASMA PROGESTERONE PREGNANCY PRO-ESTRUS REPRODUCTIVE SUCCESS 413 Veterinary science |
spellingShingle |
ALOPEX-LAGOPUS Dog FERTILITY Fertility control Finrozole Fur bearing animal INSEMINATION OOCYTE MATURATION OVARIAN-FUNCTION Oestrus inhibition PERIPHERAL PLASMA PLASMA PROGESTERONE PREGNANCY PRO-ESTRUS REPRODUCTIVE SUCCESS 413 Veterinary science Lindh, Lena Lindeberg, H. Banting, A Banting, S. Sainmaa, S. Beasley, S. Korhonen, H. Peltoniemi, Olli Administration of aromatase inhibitor MPV-2213ad to blue fox vixens (Vulpes lagopus) as a model for contraception in female dogs |
topic_facet |
ALOPEX-LAGOPUS Dog FERTILITY Fertility control Finrozole Fur bearing animal INSEMINATION OOCYTE MATURATION OVARIAN-FUNCTION Oestrus inhibition PERIPHERAL PLASMA PLASMA PROGESTERONE PREGNANCY PRO-ESTRUS REPRODUCTIVE SUCCESS 413 Veterinary science |
description |
The interest in non-surgical approaches to contraception and fertility control in female dogs has increased in recent years. In this study the effect of an aromatase inhibitor (finrozole) was evaluated in fur production animals, farmed blue fox vixens, as a model for contraception in bitches. A total of 80 vixens were divided into 4 groups, receiving orally placebo (A) or finrozole 0.5 mg/kg (B), 3.5 mg/kg (C) or 24.5 mg/kg (D) for 21 consecutive days beginning in the pre-ovulatory period of heat. Monitoring of the vixens included clinical signs of heat, measurement of vaginal electrical resistance (VER) as well as oestradiol and progesterone concentrations in plasma. The approximate relation of the start of treatment to ovulation varied from 11 days before to one day after ovulation provided that the LH peak occurred 0.5 -2 days before the VER peak and ovulation was then estimated to occur 2 days after the LH peak. Seventy vixens were artificially inseminated within 8 h after a 50 Omega decline in vaginal electrical resistance was detected. Ten vixens were not inseminated. Pregnancy was confirmed by transabdominal ultrasound examination and birth of cubs was recorded. The pregnancy rates in the groups were 89.5% (A), 81.3% (B), 55.6% (C) and 52.9% (D). The average number of live born pups in the four groups was 9.4 (A), 7.0 (B), 5.8 (C), and 3.8 (D), respectively. No deleterious effects (for instance malformations) of finrozole on pups could be verified. The administration of finrozole did not have a significant effect on oestradiol parameters and VER values in vixens. Progesterone values were significantly higher in treatment groups compared with the placebo group. The results indicate that pregnancy could be avoided by finrozole provided that doses of >= 3.5 mg/kg were used and the treatment was initiated at least four days before the day of artificial insemination. This corresponds with two to six days before ovulation provided that the LH peak occurred 0.5-2 days before the VER peak and that ovulation ... |
author2 |
Animal Reproduction Science Production Animal Medicine |
format |
Article in Journal/Newspaper |
author |
Lindh, Lena Lindeberg, H. Banting, A Banting, S. Sainmaa, S. Beasley, S. Korhonen, H. Peltoniemi, Olli |
author_facet |
Lindh, Lena Lindeberg, H. Banting, A Banting, S. Sainmaa, S. Beasley, S. Korhonen, H. Peltoniemi, Olli |
author_sort |
Lindh, Lena |
title |
Administration of aromatase inhibitor MPV-2213ad to blue fox vixens (Vulpes lagopus) as a model for contraception in female dogs |
title_short |
Administration of aromatase inhibitor MPV-2213ad to blue fox vixens (Vulpes lagopus) as a model for contraception in female dogs |
title_full |
Administration of aromatase inhibitor MPV-2213ad to blue fox vixens (Vulpes lagopus) as a model for contraception in female dogs |
title_fullStr |
Administration of aromatase inhibitor MPV-2213ad to blue fox vixens (Vulpes lagopus) as a model for contraception in female dogs |
title_full_unstemmed |
Administration of aromatase inhibitor MPV-2213ad to blue fox vixens (Vulpes lagopus) as a model for contraception in female dogs |
title_sort |
administration of aromatase inhibitor mpv-2213ad to blue fox vixens (vulpes lagopus) as a model for contraception in female dogs |
publisher |
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC |
publishDate |
2020 |
url |
http://hdl.handle.net/10138/318028 |
genre |
Alopex lagopus Vulpes lagopus |
genre_facet |
Alopex lagopus Vulpes lagopus |
op_relation |
10.1016/j.theriogenology.2020.04.009 Lindh , L , Lindeberg , H , Banting , A , Banting , S , Sainmaa , S , Beasley , S , Korhonen , H & Peltoniemi , O 2020 , ' Administration of aromatase inhibitor MPV-2213ad to blue fox vixens (Vulpes lagopus) as a model for contraception in female dogs ' , Theriogenology , vol. 152 , pp. 53-63 . https://doi.org/10.1016/j.theriogenology.2020.04.009 ORCID: /0000-0002-9481-1837/work/78162561 bb56380a-350d-4ad3-99de-bb9477e37100 http://hdl.handle.net/10138/318028 000538937500007 |
op_rights |
cc_by_nc_nd openAccess info:eu-repo/semantics/openAccess |
container_title |
Theriogenology |
container_volume |
152 |
container_start_page |
53 |
op_container_end_page |
63 |
_version_ |
1787430071485595648 |