Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts
Abstract Background The study aimed to explore the association between early life and life-course exposure to social disadvantage and later life body mass index (BMI) accounting for genetic predisposition and maternal BMI. Methods We studied participants of Helsinki Birth Cohort Study born in 1934–1...
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/315202 2023-08-20T04:08:44+02:00 Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts Lowry, Estelle Rautio, Nina Wasenius, Niko Bond, Tom A Lahti, Jari Tzoulaki, Ioanna Dehghan, Abbas Heiskala, Anni Ala-Mursula, Leena Miettunen, Jouko Eriksson, Johan Järvelin, Marjo-Riitta Sebert, Sylvain 2020-05-24T03:46:20Z application/pdf http://hdl.handle.net/10138/315202 eng eng BioMed Central BMC Public Health. 2020 May 18;20(1):708 http://hdl.handle.net/10138/315202 The Author(s) Early life Social disadvantage Body mass index (BMI) Maternal Polygenic risk score for BMI http://purl.org/eprint/entityType/ScholarlyWork http://purl.org/eprint/entityType/Expression http://purl.org/eprint/type/JournalArticle 2020 ftunivhelsihelda 2023-07-28T06:07:12Z Abstract Background The study aimed to explore the association between early life and life-course exposure to social disadvantage and later life body mass index (BMI) accounting for genetic predisposition and maternal BMI. Methods We studied participants of Helsinki Birth Cohort Study born in 1934–1944 (HBCS1934–1944, n = 1277) and Northern Finland Birth Cohorts born in 1966 and 1986 (NFBC1966, n = 5807, NFBC1986, n = 6717). Factor analysis produced scores of social disadvantage based on social and economic elements in early life and adulthood/over the life course, and was categorized as high, intermediate and low. BMI was measured at 62 years in HBCS1934–1944, at 46 years in NFBC1966 and at 16 years in NFBC1986. Multivariable linear regression analysis was used to explore associations between social disadvantages and BMI after adjustments for polygenic risk score for BMI (PRS BMI), maternal BMI and sex. Results The association between exposure to high early social disadvantage and increased later life BMI persisted after adjustments (β = 0.79, 95% CI, 0.33, 1.25, p < 0.001) in NFBC1966. In NFBC1986 this association was attenuated by PRS BMI (p = 0.181), and in HBCS1934–1944 there was no association between high early social disadvantage and increased later life BMI (β 0.22, 95% CI –0.91,1.35, p = 0.700). In HBCS1934–1944 and NFBC1966, participants who had reduced their exposure to social disadvantage during the life-course had lower later life BMI than those who had increased their exposure (β − 1.34, [− 2.37,-0.31], p = 0.011; β − 0.46, [− 0.89,-0.03], p = 0.038, respectively). Conclusions High social disadvantage in early life appears to be associated with higher BMI in later life. Reducing exposure to social disadvantage during the life-course may be a potential pathway for obesity reduction. Article in Journal/Newspaper Northern Finland Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
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Open Polar |
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Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
op_collection_id |
ftunivhelsihelda |
language |
English |
topic |
Early life Social disadvantage Body mass index (BMI) Maternal Polygenic risk score for BMI |
spellingShingle |
Early life Social disadvantage Body mass index (BMI) Maternal Polygenic risk score for BMI Lowry, Estelle Rautio, Nina Wasenius, Niko Bond, Tom A Lahti, Jari Tzoulaki, Ioanna Dehghan, Abbas Heiskala, Anni Ala-Mursula, Leena Miettunen, Jouko Eriksson, Johan Järvelin, Marjo-Riitta Sebert, Sylvain Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts |
topic_facet |
Early life Social disadvantage Body mass index (BMI) Maternal Polygenic risk score for BMI |
description |
Abstract Background The study aimed to explore the association between early life and life-course exposure to social disadvantage and later life body mass index (BMI) accounting for genetic predisposition and maternal BMI. Methods We studied participants of Helsinki Birth Cohort Study born in 1934–1944 (HBCS1934–1944, n = 1277) and Northern Finland Birth Cohorts born in 1966 and 1986 (NFBC1966, n = 5807, NFBC1986, n = 6717). Factor analysis produced scores of social disadvantage based on social and economic elements in early life and adulthood/over the life course, and was categorized as high, intermediate and low. BMI was measured at 62 years in HBCS1934–1944, at 46 years in NFBC1966 and at 16 years in NFBC1986. Multivariable linear regression analysis was used to explore associations between social disadvantages and BMI after adjustments for polygenic risk score for BMI (PRS BMI), maternal BMI and sex. Results The association between exposure to high early social disadvantage and increased later life BMI persisted after adjustments (β = 0.79, 95% CI, 0.33, 1.25, p < 0.001) in NFBC1966. In NFBC1986 this association was attenuated by PRS BMI (p = 0.181), and in HBCS1934–1944 there was no association between high early social disadvantage and increased later life BMI (β 0.22, 95% CI –0.91,1.35, p = 0.700). In HBCS1934–1944 and NFBC1966, participants who had reduced their exposure to social disadvantage during the life-course had lower later life BMI than those who had increased their exposure (β − 1.34, [− 2.37,-0.31], p = 0.011; β − 0.46, [− 0.89,-0.03], p = 0.038, respectively). Conclusions High social disadvantage in early life appears to be associated with higher BMI in later life. Reducing exposure to social disadvantage during the life-course may be a potential pathway for obesity reduction. |
format |
Article in Journal/Newspaper |
author |
Lowry, Estelle Rautio, Nina Wasenius, Niko Bond, Tom A Lahti, Jari Tzoulaki, Ioanna Dehghan, Abbas Heiskala, Anni Ala-Mursula, Leena Miettunen, Jouko Eriksson, Johan Järvelin, Marjo-Riitta Sebert, Sylvain |
author_facet |
Lowry, Estelle Rautio, Nina Wasenius, Niko Bond, Tom A Lahti, Jari Tzoulaki, Ioanna Dehghan, Abbas Heiskala, Anni Ala-Mursula, Leena Miettunen, Jouko Eriksson, Johan Järvelin, Marjo-Riitta Sebert, Sylvain |
author_sort |
Lowry, Estelle |
title |
Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts |
title_short |
Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts |
title_full |
Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts |
title_fullStr |
Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts |
title_full_unstemmed |
Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts |
title_sort |
early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of finnish birth cohorts |
publisher |
BioMed Central |
publishDate |
2020 |
url |
http://hdl.handle.net/10138/315202 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
BMC Public Health. 2020 May 18;20(1):708 http://hdl.handle.net/10138/315202 |
op_rights |
The Author(s) |
_version_ |
1774721175539154944 |