Effect of polycystic ovary syndrome on cardiac autonomic function at a late fertile age: a prospective Northern Finland Birth Cohort 1966 study
OBJECTIVES: Previous studies of women in their 20s and 30s have reported impaired autonomic function in women with polycystic ovary syndrome (PCOS). We aimed to study, for the first time, whether PCOS is associated with impaired cardiac autonomic function independent of metabolic and hormonal status...
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/313009 2024-01-07T09:45:27+01:00 Effect of polycystic ovary syndrome on cardiac autonomic function at a late fertile age: a prospective Northern Finland Birth Cohort 1966 study Ollila, Meri-Maija Kiviniemi, Antti Stener-Victorin, Elisabet Tulppo, Mikko Puukka, Katri Tapanainen, Juha Franks, Stephen Morin-Papunen, Laure Piltonen, Terhi HUS Gynecology and Obstetrics Reproductive Disease Modeling Clinicum Department of Obstetrics and Gynecology University of Helsinki 2020-03-05T07:29:01Z 10 application/pdf http://hdl.handle.net/10138/313009 eng eng BMJ Publishing Group Ltd 10.1136/bmjopen-2019-033780 Ollila , M-M , Kiviniemi , A , Stener-Victorin , E , Tulppo , M , Puukka , K , Tapanainen , J , Franks , S , Morin-Papunen , L & Piltonen , T 2019 , ' Effect of polycystic ovary syndrome on cardiac autonomic function at a late fertile age: a prospective Northern Finland Birth Cohort 1966 study ' , BMJ Open , vol. 9 , no. 12 , e033780 . https://doi.org/10.1136/bmjopen-2019-033780 RIS: urn:574C2B60F80F0DA36555C6AEABE7E548 a0ec2f1d-066f-4f2d-af3f-1ec1cf174286 http://hdl.handle.net/10138/313009 000512773400271 cc_by_nc openAccess info:eu-repo/semantics/openAccess PCOS heart rate heart rate variability metabolism obesity 3123 Gynaecology and paediatrics Article publishedVersion 2020 ftunivhelsihelda 2023-12-14T00:10:46Z OBJECTIVES: Previous studies of women in their 20s and 30s have reported impaired autonomic function in women with polycystic ovary syndrome (PCOS). We aimed to study, for the first time, whether PCOS is associated with impaired cardiac autonomic function independent of metabolic and hormonal status in their late reproductive years. DESIGN: A prospective Northern Finland Birth Cohort 1966 (NFBC1966) study including 5889 women born in 1966 and followed through the age of 46. At that age, n=3706/5123 women (72%) answered the postal questionnaires and n=3280/5123 women (64%) participated in the clinical examination. SETTING: General community. PARTICIPANTS: The sample included women presenting both irregular menses (oligomenorrhoea or amenorrhoea) and hirsutism at age 31 (n=125) or with formally diagnosed PCOS by age 46 (n=181) and women without PCOS symptoms or diagnosis (n=1577). PRIMARY AND SECONDARY OUTCOME MEASURES: Heart rate variability parameters: the root mean square of successive R-R differences (rMSSD), spectral power densities (LF: low frequency and HF: high frequency) and baroreflex sensitivity (BRS). RESULTS: We found that parasympathetic activity (assessed by rMSSD: 19.5 (12.4; 31.9) vs 24.3 (16.1; 34.8) ms, p=0.004 and HF: 172 (75; 399) vs 261 (112; 565) ms(2), p=0.002) and BRS (6.13±3.12 vs 6.99±3.52 ms/mm Hg, p=0.036) were lower in women with PCOS compared with the controls. However, in the multivariate regression analysis, PCOS, body mass index and the free androgen index did not significantly associate with rMSSD, whereas blood pressure, insulin resistance and triglycerides did. CONCLUSIONS: We report here for the first time that late reproductive-aged women with PCOS display impaired cardiac autonomic function manifested as decreased vagal activity. Metabolic status, rather than hyperandrogenaemia and PCOS per se, was the strongest contributing factor. Given the link between cardiac morbidity and impaired autonomic function, the findings underline the importance of screening and treating ... Article in Journal/Newspaper Northern Finland HELDA – University of Helsinki Open Repository BMJ Open 9 12 e033780 |
institution |
Open Polar |
collection |
HELDA – University of Helsinki Open Repository |
op_collection_id |
ftunivhelsihelda |
language |
English |
topic |
PCOS heart rate heart rate variability metabolism obesity 3123 Gynaecology and paediatrics |
spellingShingle |
PCOS heart rate heart rate variability metabolism obesity 3123 Gynaecology and paediatrics Ollila, Meri-Maija Kiviniemi, Antti Stener-Victorin, Elisabet Tulppo, Mikko Puukka, Katri Tapanainen, Juha Franks, Stephen Morin-Papunen, Laure Piltonen, Terhi Effect of polycystic ovary syndrome on cardiac autonomic function at a late fertile age: a prospective Northern Finland Birth Cohort 1966 study |
topic_facet |
PCOS heart rate heart rate variability metabolism obesity 3123 Gynaecology and paediatrics |
description |
OBJECTIVES: Previous studies of women in their 20s and 30s have reported impaired autonomic function in women with polycystic ovary syndrome (PCOS). We aimed to study, for the first time, whether PCOS is associated with impaired cardiac autonomic function independent of metabolic and hormonal status in their late reproductive years. DESIGN: A prospective Northern Finland Birth Cohort 1966 (NFBC1966) study including 5889 women born in 1966 and followed through the age of 46. At that age, n=3706/5123 women (72%) answered the postal questionnaires and n=3280/5123 women (64%) participated in the clinical examination. SETTING: General community. PARTICIPANTS: The sample included women presenting both irregular menses (oligomenorrhoea or amenorrhoea) and hirsutism at age 31 (n=125) or with formally diagnosed PCOS by age 46 (n=181) and women without PCOS symptoms or diagnosis (n=1577). PRIMARY AND SECONDARY OUTCOME MEASURES: Heart rate variability parameters: the root mean square of successive R-R differences (rMSSD), spectral power densities (LF: low frequency and HF: high frequency) and baroreflex sensitivity (BRS). RESULTS: We found that parasympathetic activity (assessed by rMSSD: 19.5 (12.4; 31.9) vs 24.3 (16.1; 34.8) ms, p=0.004 and HF: 172 (75; 399) vs 261 (112; 565) ms(2), p=0.002) and BRS (6.13±3.12 vs 6.99±3.52 ms/mm Hg, p=0.036) were lower in women with PCOS compared with the controls. However, in the multivariate regression analysis, PCOS, body mass index and the free androgen index did not significantly associate with rMSSD, whereas blood pressure, insulin resistance and triglycerides did. CONCLUSIONS: We report here for the first time that late reproductive-aged women with PCOS display impaired cardiac autonomic function manifested as decreased vagal activity. Metabolic status, rather than hyperandrogenaemia and PCOS per se, was the strongest contributing factor. Given the link between cardiac morbidity and impaired autonomic function, the findings underline the importance of screening and treating ... |
author2 |
HUS Gynecology and Obstetrics Reproductive Disease Modeling Clinicum Department of Obstetrics and Gynecology University of Helsinki |
format |
Article in Journal/Newspaper |
author |
Ollila, Meri-Maija Kiviniemi, Antti Stener-Victorin, Elisabet Tulppo, Mikko Puukka, Katri Tapanainen, Juha Franks, Stephen Morin-Papunen, Laure Piltonen, Terhi |
author_facet |
Ollila, Meri-Maija Kiviniemi, Antti Stener-Victorin, Elisabet Tulppo, Mikko Puukka, Katri Tapanainen, Juha Franks, Stephen Morin-Papunen, Laure Piltonen, Terhi |
author_sort |
Ollila, Meri-Maija |
title |
Effect of polycystic ovary syndrome on cardiac autonomic function at a late fertile age: a prospective Northern Finland Birth Cohort 1966 study |
title_short |
Effect of polycystic ovary syndrome on cardiac autonomic function at a late fertile age: a prospective Northern Finland Birth Cohort 1966 study |
title_full |
Effect of polycystic ovary syndrome on cardiac autonomic function at a late fertile age: a prospective Northern Finland Birth Cohort 1966 study |
title_fullStr |
Effect of polycystic ovary syndrome on cardiac autonomic function at a late fertile age: a prospective Northern Finland Birth Cohort 1966 study |
title_full_unstemmed |
Effect of polycystic ovary syndrome on cardiac autonomic function at a late fertile age: a prospective Northern Finland Birth Cohort 1966 study |
title_sort |
effect of polycystic ovary syndrome on cardiac autonomic function at a late fertile age: a prospective northern finland birth cohort 1966 study |
publisher |
BMJ Publishing Group Ltd |
publishDate |
2020 |
url |
http://hdl.handle.net/10138/313009 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
10.1136/bmjopen-2019-033780 Ollila , M-M , Kiviniemi , A , Stener-Victorin , E , Tulppo , M , Puukka , K , Tapanainen , J , Franks , S , Morin-Papunen , L & Piltonen , T 2019 , ' Effect of polycystic ovary syndrome on cardiac autonomic function at a late fertile age: a prospective Northern Finland Birth Cohort 1966 study ' , BMJ Open , vol. 9 , no. 12 , e033780 . https://doi.org/10.1136/bmjopen-2019-033780 RIS: urn:574C2B60F80F0DA36555C6AEABE7E548 a0ec2f1d-066f-4f2d-af3f-1ec1cf174286 http://hdl.handle.net/10138/313009 000512773400271 |
op_rights |
cc_by_nc openAccess info:eu-repo/semantics/openAccess |
container_title |
BMJ Open |
container_volume |
9 |
container_issue |
12 |
container_start_page |
e033780 |
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1787426992848633856 |