A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes : results from an exome-wide association study of albuminuria

• Published in: Diabetologia
• Main Authors: Ahluwalia, Tarunveer S., Schulz, Christina-Alexandra, Waage, Johannes, Skaaby, Tea, Sandholm, Niina, van Zuydam, Natalie, Charmet, Romain, Bork-Jensen, Jette, Almgren, Peter, Thuesen, Betina H., Bedin, Mathilda, Brandslund, Ivan, Christensen, Cramer K., Linneberg, Allan, Ahlqvist, Emma, Groop, Per-Henrik, Hadjadj, Samy, Tregouet, David-Alexandre, Jorgensen, Marit E., Grarup, Niels, Pedersen, Oluf, Simons, Matias, Groop, Leif, Orho-Melander, Marju, McCarthy, Mark I., Melander, Olle, Rossing, Peter, Kilpeläinen, Tuomas O., Hansen, Torben
• Other Authors: Clinicum, Research Programs Unit, Nefrologian yksikkö, Diabetes and Obesity Research Program, Department of Medicine, Per Henrik Groop / Principal Investigator, Centre of Excellence in Complex Disease Genetics, Institute for Molecular Medicine Finland, University of Helsinki, HUS Abdominal Center
• Format: Article in Journal/Newspaper
• Language: English
• Published: Springer 2019
• Subjects: Albuminuria; Diabetes; DKD; Exome chip; Genetics; Genome-wide association study; Kidney disease; GWAS; Rare variant; SKAT; Type 2 diabetes; GENOME-WIDE; KIDNEY-DISEASE; RISK; REVEALS; LOCI; METAANALYSIS; PROTECTION; RECEPTORS; DISCOVERY; FRAMEWORK; 3121 General medicine; internal medicine and other clinical medicine; 3111 Biomedicine; 1184 Genetics; developmental biology; physiology; Skat; greenlander*
• Online Access: http://hdl.handle.net/10138/298740

Aims/hypothesisIdentifying rare coding variants associated with albuminuria may open new avenues for preventing chronic kidney disease and end-stage renal disease, which are highly prevalent in individuals with diabetes. Efforts to identify genetic susceptibility variants for albuminuria have so far...