Spermatogonial quantity in human prepubertal testicular tissue collected for fertility preservation prior to potentially sterilizing therapy

• Published in: Human Reproduction
• Main Authors: Stukenborg, J. -B., Alves-Lopes, J. P., Kurek, M., Albalushi, H., Reda, A., Keros, V., Töhönen, V., Bjarnason, R., Romerius, P., Sundin, M., Nyström, U. Noren, Langenskiöld, C., Vogt, H., Henningsohn, L., Mitchell, R. T., Söder, O., Petersen, C., Jahnukainen, K.
• Other Authors: Children's Hospital, Clinicum, University of Helsinki, HUS Children and Adolescents
• Format: Article in Journal/Newspaper
• Language: English
• Published: Oxford University Press 2019
• Subjects: fertility preservation; childhood cancer; sickle cell disease; alkylating agents; spermatogonial quantity; SICKLE-CELL-DISEASE; CANCER-TREATMENT; WORKING PARTY; CHILDHOOD; CHILDREN; HYDROXYUREA; CRYOPRESERVATION; TRANSPLANTATION; ADOLESCENTS; EBMT; 3123 Gynaecology and paediatrics; Sickle; Iceland
• Online Access: http://hdl.handle.net/10138/288214

STUDY QUESTION: Does chemotherapy exposure (with or without alkylating agents) or primary diagnosis affect spermatogonial quantity in human prepubertal testicular tissue? SUMMARY ANSWER: Spermatogonial quantity is significantly reduced in testes of prepubertal boys treated with alkylating agent ther...