Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk
Background: The etiology of type 1 diabetes (T1D) is largely unknown. Infections and microbial exposures are believed to play a role in the pathogenesis and in the development of islet autoimmunity in genetically susceptible individuals. Objective: To assess the relationships between early childhood...
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/235777 2023-08-20T04:07:42+02:00 Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk Mustonen, Neea Helsingin yliopisto, Lääketieteellinen tiedekunta University of Helsinki, Faculty of Medicine Helsingfors universitet, Medicinska fakulteten 2018 http://hdl.handle.net/10138/235777 eng eng Helsingin yliopisto University of Helsinki Helsingfors universitet URN:NBN:fi:hulib-201805211980 http://hdl.handle.net/10138/235777 Paediatrics Lastentaudit Barnsjukdomar pro gradu -tutkielmat master's thesis pro gradu-avhandlingar 2018 ftunivhelsihelda 2023-07-28T06:02:38Z Background: The etiology of type 1 diabetes (T1D) is largely unknown. Infections and microbial exposures are believed to play a role in the pathogenesis and in the development of islet autoimmunity in genetically susceptible individuals. Objective: To assess the relationships between early childhood infections, islet autoimmunity, and progression to T1D in genetically predisposed children. Methods: Children with HLA-conferred disease susceptibility (N=790; 51.5% males) from Finland (n=386), Estonia (n=322), and Russian Karelia (n=82) were observed from birth up to the age of 3 years. Children attended clinical visits at the age of 3, 6, 12, 18, 24, and 36 months. Serum samples for analyzing T1D-associated autoimmune markers were collected and health data recorded during the visits. Results: Children developing islet autoimmunity (n=46, 5.8%) had more infections during the first year of life (3.0 vs. 3.0, mean rank 439.1 vs. 336.2; p=0.001) and their first infection occurred earlier (3.6 vs. 5.0 months; p=0.005) than children with no islet autoimmunity. By May 2016, seven children (0.9%) had developed T1D (progressors). Compared to non-diabetic children, T1D progressors were younger at first infection (2.2 vs. 4.9 months; p=0.004) and had more infections during the first 2 years of life (during each year 6.0 vs. 3.0; p=0.001 and p=0.027, respectively). By 3 years of age, the T1D progressors had twice as many infections as the other children (17.5 vs. 9.0; p=0.006). Conclusions: Early childhood infections may play an important role in the pathogenesis of T1D. Current findings may reflect either differences in microbial exposures or early immunological aberrations making diabetes-prone children more susceptible to infections. Master Thesis karelia* Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
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Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
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ftunivhelsihelda |
language |
English |
topic |
Paediatrics Lastentaudit Barnsjukdomar |
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Paediatrics Lastentaudit Barnsjukdomar Mustonen, Neea Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk |
topic_facet |
Paediatrics Lastentaudit Barnsjukdomar |
description |
Background: The etiology of type 1 diabetes (T1D) is largely unknown. Infections and microbial exposures are believed to play a role in the pathogenesis and in the development of islet autoimmunity in genetically susceptible individuals. Objective: To assess the relationships between early childhood infections, islet autoimmunity, and progression to T1D in genetically predisposed children. Methods: Children with HLA-conferred disease susceptibility (N=790; 51.5% males) from Finland (n=386), Estonia (n=322), and Russian Karelia (n=82) were observed from birth up to the age of 3 years. Children attended clinical visits at the age of 3, 6, 12, 18, 24, and 36 months. Serum samples for analyzing T1D-associated autoimmune markers were collected and health data recorded during the visits. Results: Children developing islet autoimmunity (n=46, 5.8%) had more infections during the first year of life (3.0 vs. 3.0, mean rank 439.1 vs. 336.2; p=0.001) and their first infection occurred earlier (3.6 vs. 5.0 months; p=0.005) than children with no islet autoimmunity. By May 2016, seven children (0.9%) had developed T1D (progressors). Compared to non-diabetic children, T1D progressors were younger at first infection (2.2 vs. 4.9 months; p=0.004) and had more infections during the first 2 years of life (during each year 6.0 vs. 3.0; p=0.001 and p=0.027, respectively). By 3 years of age, the T1D progressors had twice as many infections as the other children (17.5 vs. 9.0; p=0.006). Conclusions: Early childhood infections may play an important role in the pathogenesis of T1D. Current findings may reflect either differences in microbial exposures or early immunological aberrations making diabetes-prone children more susceptible to infections. |
author2 |
Helsingin yliopisto, Lääketieteellinen tiedekunta University of Helsinki, Faculty of Medicine Helsingfors universitet, Medicinska fakulteten |
format |
Master Thesis |
author |
Mustonen, Neea |
author_facet |
Mustonen, Neea |
author_sort |
Mustonen, Neea |
title |
Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk |
title_short |
Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk |
title_full |
Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk |
title_fullStr |
Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk |
title_full_unstemmed |
Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk |
title_sort |
early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with hla-conferred disease risk |
publisher |
Helsingin yliopisto |
publishDate |
2018 |
url |
http://hdl.handle.net/10138/235777 |
genre |
karelia* |
genre_facet |
karelia* |
op_relation |
URN:NBN:fi:hulib-201805211980 http://hdl.handle.net/10138/235777 |
_version_ |
1774719519510495232 |