Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats
Fucus vesiculosus L., known as bladderwrack, belongs to the brown seaweeds, which are widely distributed throughout northern Russia, Atlantic shores of Europe, the Baltic Sea, Greenland, the Azores, the Canary Islands, and shores of the Pacific Ocean. Fucoidan is a major fucose-rich sulfated polysac...
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Online Access: | http://hdl.handle.net/10138/235213 |
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/235213 2024-01-07T09:43:40+01:00 Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats Pozharitskaya, Olga N. Shikov, Alexander N. Faustova, Natalya M. Obluchinskaya, Ekaterina D. Kosman, Vera M. Vuorela, Heikki Makarov, Valery G. Faculty of Pharmacy Division of Pharmaceutical Biosciences Pharmaceutical Design and Discovery group Drug Research Program 2018-05-17T14:05:01Z 10 application/pdf http://hdl.handle.net/10138/235213 eng eng MDPI 10.3390/md16040132 This study was done without financial support. The cost of publishing in open access will be paid from the budget of the Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki. Pozharitskaya , O N , Shikov , A N , Faustova , N M , Obluchinskaya , E D , Kosman , V M , Vuorela , H & Makarov , V G 2018 , ' Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats ' , Marine Drugs , vol. 16 , no. 4 , 132 . https://doi.org/10.3390/md16040132 85045541853 256eac7e-8b32-44e7-b344-8e4462e33136 http://hdl.handle.net/10138/235213 000431068000034 cc_by openAccess info:eu-repo/semantics/openAccess anti-Xa activity Fucus vesiculosus fucoidan kidneys liver pharmacokinetic spleen MOLECULAR-WEIGHT SULFATED POLYSACCHARIDES UNFRACTIONATED HEPARIN BROWN SEAWEEDS HUMAN PLASMA ANTICOAGULANT OSTEOARTHRITIS ENOXAPARIN ANTIBODY EXTRACT 317 Pharmacy Article publishedVersion 2018 ftunivhelsihelda 2023-12-14T00:07:01Z Fucus vesiculosus L., known as bladderwrack, belongs to the brown seaweeds, which are widely distributed throughout northern Russia, Atlantic shores of Europe, the Baltic Sea, Greenland, the Azores, the Canary Islands, and shores of the Pacific Ocean. Fucoidan is a major fucose-rich sulfated polysaccharide found in Fucus (F.) vesiculosus. The pharmacokinetic profiling of active compounds is essential for drug development and approval. The aim of the study was to evaluate the pharmacokinetics and tissue distribution of fucoidan in rats after a single-dose oral administration. Fucoidan was isolated from F. vesiculosus. The method of measuring anti-activated factor X (anti-Xa) activity by amidolytic assay was used to analyze the plasma and tissue concentrations of fucoidan. The tissue distribution of fucoidan after intragastric administration to the rats was characterized, and it exhibited considerable heterogeneity. Fucoidan preferentially accumulates in the kidneys (AUC(0-t) = 10.74 mu g.h/g; C-max = 1.23 mu g/g after 5 h), spleen (AUC(0-t) = 6.89 mu g.h/g; C-max = 0.78 mu g/g after 3 h), and liver (AUC(0-t) = 3.26 mu g.h/g; C-max = 0.53 mu g/g after 2 h) and shows a relatively long absorption time and extended circulation in the blood, with a mean residence time (MRT) = 6.79 h. The outcome of this study provides additional scientific data for traditional use of fucoidan-containing plants and offers tangible support for the continued development of new effective pharmaceuticals using fucoidan. Peer reviewed Article in Journal/Newspaper Greenland HELDA – University of Helsinki Open Repository Greenland Pacific Marine Drugs 16 4 132 |
institution |
Open Polar |
collection |
HELDA – University of Helsinki Open Repository |
op_collection_id |
ftunivhelsihelda |
language |
English |
topic |
anti-Xa activity Fucus vesiculosus fucoidan kidneys liver pharmacokinetic spleen MOLECULAR-WEIGHT SULFATED POLYSACCHARIDES UNFRACTIONATED HEPARIN BROWN SEAWEEDS HUMAN PLASMA ANTICOAGULANT OSTEOARTHRITIS ENOXAPARIN ANTIBODY EXTRACT 317 Pharmacy |
spellingShingle |
anti-Xa activity Fucus vesiculosus fucoidan kidneys liver pharmacokinetic spleen MOLECULAR-WEIGHT SULFATED POLYSACCHARIDES UNFRACTIONATED HEPARIN BROWN SEAWEEDS HUMAN PLASMA ANTICOAGULANT OSTEOARTHRITIS ENOXAPARIN ANTIBODY EXTRACT 317 Pharmacy Pozharitskaya, Olga N. Shikov, Alexander N. Faustova, Natalya M. Obluchinskaya, Ekaterina D. Kosman, Vera M. Vuorela, Heikki Makarov, Valery G. Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats |
topic_facet |
anti-Xa activity Fucus vesiculosus fucoidan kidneys liver pharmacokinetic spleen MOLECULAR-WEIGHT SULFATED POLYSACCHARIDES UNFRACTIONATED HEPARIN BROWN SEAWEEDS HUMAN PLASMA ANTICOAGULANT OSTEOARTHRITIS ENOXAPARIN ANTIBODY EXTRACT 317 Pharmacy |
description |
Fucus vesiculosus L., known as bladderwrack, belongs to the brown seaweeds, which are widely distributed throughout northern Russia, Atlantic shores of Europe, the Baltic Sea, Greenland, the Azores, the Canary Islands, and shores of the Pacific Ocean. Fucoidan is a major fucose-rich sulfated polysaccharide found in Fucus (F.) vesiculosus. The pharmacokinetic profiling of active compounds is essential for drug development and approval. The aim of the study was to evaluate the pharmacokinetics and tissue distribution of fucoidan in rats after a single-dose oral administration. Fucoidan was isolated from F. vesiculosus. The method of measuring anti-activated factor X (anti-Xa) activity by amidolytic assay was used to analyze the plasma and tissue concentrations of fucoidan. The tissue distribution of fucoidan after intragastric administration to the rats was characterized, and it exhibited considerable heterogeneity. Fucoidan preferentially accumulates in the kidneys (AUC(0-t) = 10.74 mu g.h/g; C-max = 1.23 mu g/g after 5 h), spleen (AUC(0-t) = 6.89 mu g.h/g; C-max = 0.78 mu g/g after 3 h), and liver (AUC(0-t) = 3.26 mu g.h/g; C-max = 0.53 mu g/g after 2 h) and shows a relatively long absorption time and extended circulation in the blood, with a mean residence time (MRT) = 6.79 h. The outcome of this study provides additional scientific data for traditional use of fucoidan-containing plants and offers tangible support for the continued development of new effective pharmaceuticals using fucoidan. Peer reviewed |
author2 |
Faculty of Pharmacy Division of Pharmaceutical Biosciences Pharmaceutical Design and Discovery group Drug Research Program |
format |
Article in Journal/Newspaper |
author |
Pozharitskaya, Olga N. Shikov, Alexander N. Faustova, Natalya M. Obluchinskaya, Ekaterina D. Kosman, Vera M. Vuorela, Heikki Makarov, Valery G. |
author_facet |
Pozharitskaya, Olga N. Shikov, Alexander N. Faustova, Natalya M. Obluchinskaya, Ekaterina D. Kosman, Vera M. Vuorela, Heikki Makarov, Valery G. |
author_sort |
Pozharitskaya, Olga N. |
title |
Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats |
title_short |
Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats |
title_full |
Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats |
title_fullStr |
Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats |
title_full_unstemmed |
Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats |
title_sort |
pharmacokinetic and tissue distribution of fucoidan from fucus vesiculosus after oral administration to rats |
publisher |
MDPI |
publishDate |
2018 |
url |
http://hdl.handle.net/10138/235213 |
geographic |
Greenland Pacific |
geographic_facet |
Greenland Pacific |
genre |
Greenland |
genre_facet |
Greenland |
op_relation |
10.3390/md16040132 This study was done without financial support. The cost of publishing in open access will be paid from the budget of the Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki. Pozharitskaya , O N , Shikov , A N , Faustova , N M , Obluchinskaya , E D , Kosman , V M , Vuorela , H & Makarov , V G 2018 , ' Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats ' , Marine Drugs , vol. 16 , no. 4 , 132 . https://doi.org/10.3390/md16040132 85045541853 256eac7e-8b32-44e7-b344-8e4462e33136 http://hdl.handle.net/10138/235213 000431068000034 |
op_rights |
cc_by openAccess info:eu-repo/semantics/openAccess |
container_title |
Marine Drugs |
container_volume |
16 |
container_issue |
4 |
container_start_page |
132 |
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1787424948536475648 |