Incidence and predictors of Uveitis in juvenile idiopathic arthritis in a Nordic long-term cohort study
Background: The incidence of uveitis associated with juvenile idiopathic arthritis (JIA) varies around the world. Our aim was to investigate the incidence and predictors of uveitis in a Nordic population-based cohort. Methods: Consecutive JIA cases from defined geographical areas in Denmark, Finland...
Published in: | Pediatric Rheumatology |
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Online Access: | http://hdl.handle.net/10138/224273 |
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/224273 2024-01-07T09:40:44+01:00 Incidence and predictors of Uveitis in juvenile idiopathic arthritis in a Nordic long-term cohort study Nordal, Ellen Rypdal, Veronika Christoffersen, Terje Aalto, Kristiina Berntson, Lillemor Fasth, Anders Herlin, Troels Nielsen, Susan Peltoniemi, Suvi Straume, Bjorn Zak, Marek Rygg, Marite Nordic Study Grp Pediat Rheumatolo Children's Hospital University of Helsinki Clinicum HUS Children and Adolescents 2017-09-18T11:21:00Z 8 application/pdf http://hdl.handle.net/10138/224273 eng eng BioMed Central Ltd 10.1186/s12969-017-0195-8 This work was supported by grants from the Helse Nord Research Program, and the Grete Harbitz foundation. UiT the Arctic University of Norway funded the publication costs. Nordal , E , Rypdal , V , Christoffersen , T , Aalto , K , Berntson , L , Fasth , A , Herlin , T , Nielsen , S , Peltoniemi , S , Straume , B , Zak , M , Rygg , M & Nordic Study Grp Pediat Rheumatolo 2017 , ' Incidence and predictors of Uveitis in juvenile idiopathic arthritis in a Nordic long-term cohort study ' , Pediatric Rheumatology Online Journal , vol. 15 , 66 . https://doi.org/10.1186/s12969-017-0195-8 85027528899 e69bd663-23ba-4599-a1bd-cb47239b403e http://hdl.handle.net/10138/224273 000408003800001 cc_by openAccess info:eu-repo/semantics/openAccess Juvenile idiopathic arthritis Uveitis Epidemiology Biomarkers Histones Antinuclear antibody FOLLOW-UP ANTIHISTONE ANTIBODIES ANTINUCLEAR ANTIBODIES CLINICAL-FEATURES NORTHERN NORWAY DISEASE COURSE RISK-FACTORS PREVALENCE COMPLICATIONS CLASSIFICATION 3121 General medicine internal medicine and other clinical medicine 3123 Gynaecology and paediatrics Article publishedVersion 2017 ftunivhelsihelda 2023-12-14T00:12:48Z Background: The incidence of uveitis associated with juvenile idiopathic arthritis (JIA) varies around the world. Our aim was to investigate the incidence and predictors of uveitis in a Nordic population-based cohort. Methods: Consecutive JIA cases from defined geographical areas in Denmark, Finland, Sweden and Norway with disease onset between January 1997 to June 2000 were followed for median 98 months in this prospective longitudinal cohort study. Potential clinical and immunological predictors of uveitis were identified with logistic regression analysis. Results: Uveitis occurred in 89 (20.5%) of the 435 children with regular ophtalmologic follow-up among the 500 included. Chronic asymptomatic uveitis developed in 80 and acute symptomatic uveitis in 9 children. Uveitis developed at a median interval of 0.8 (range - 4.7 to 9.4) years after onset of arthritis. Predictors of uveitis were age <7 years at JIA onset (Odds ratio (OR) 2.1, 95% confidence interval (CI) 1.3 to 3.5), presence of antihistone antibodies (AHA) > 15 U/ml (OR 4.8 (1.8 to 13.4)) and antinuclear antibodies (ANA) (OR 2.4 (1.5 to 4.0)). Mean combined IgM/IgG AHA was significantly higher in the uveitis group (19.2 U/ml) than in the non-uveitis group (10.2 U/ml) (p = 0.002). Young age at JIA onset predicted uveitis in girls (p <0.001), but not in boys (p = 0.390). Conclusion: Early-onset arthritis and presence of AHA in girls, as well as presence of ANA in both genders, were significant predictors of chronic uveitis. The high incidence of uveitis in this long-term Nordic JIA cohort may have severe implications in a lifelong perspective. Peer reviewed Article in Journal/Newspaper Arctic Northern Norway HELDA – University of Helsinki Open Repository Norway Pediatric Rheumatology 15 1 |
institution |
Open Polar |
collection |
HELDA – University of Helsinki Open Repository |
op_collection_id |
ftunivhelsihelda |
language |
English |
topic |
Juvenile idiopathic arthritis Uveitis Epidemiology Biomarkers Histones Antinuclear antibody FOLLOW-UP ANTIHISTONE ANTIBODIES ANTINUCLEAR ANTIBODIES CLINICAL-FEATURES NORTHERN NORWAY DISEASE COURSE RISK-FACTORS PREVALENCE COMPLICATIONS CLASSIFICATION 3121 General medicine internal medicine and other clinical medicine 3123 Gynaecology and paediatrics |
spellingShingle |
Juvenile idiopathic arthritis Uveitis Epidemiology Biomarkers Histones Antinuclear antibody FOLLOW-UP ANTIHISTONE ANTIBODIES ANTINUCLEAR ANTIBODIES CLINICAL-FEATURES NORTHERN NORWAY DISEASE COURSE RISK-FACTORS PREVALENCE COMPLICATIONS CLASSIFICATION 3121 General medicine internal medicine and other clinical medicine 3123 Gynaecology and paediatrics Nordal, Ellen Rypdal, Veronika Christoffersen, Terje Aalto, Kristiina Berntson, Lillemor Fasth, Anders Herlin, Troels Nielsen, Susan Peltoniemi, Suvi Straume, Bjorn Zak, Marek Rygg, Marite Nordic Study Grp Pediat Rheumatolo Incidence and predictors of Uveitis in juvenile idiopathic arthritis in a Nordic long-term cohort study |
topic_facet |
Juvenile idiopathic arthritis Uveitis Epidemiology Biomarkers Histones Antinuclear antibody FOLLOW-UP ANTIHISTONE ANTIBODIES ANTINUCLEAR ANTIBODIES CLINICAL-FEATURES NORTHERN NORWAY DISEASE COURSE RISK-FACTORS PREVALENCE COMPLICATIONS CLASSIFICATION 3121 General medicine internal medicine and other clinical medicine 3123 Gynaecology and paediatrics |
description |
Background: The incidence of uveitis associated with juvenile idiopathic arthritis (JIA) varies around the world. Our aim was to investigate the incidence and predictors of uveitis in a Nordic population-based cohort. Methods: Consecutive JIA cases from defined geographical areas in Denmark, Finland, Sweden and Norway with disease onset between January 1997 to June 2000 were followed for median 98 months in this prospective longitudinal cohort study. Potential clinical and immunological predictors of uveitis were identified with logistic regression analysis. Results: Uveitis occurred in 89 (20.5%) of the 435 children with regular ophtalmologic follow-up among the 500 included. Chronic asymptomatic uveitis developed in 80 and acute symptomatic uveitis in 9 children. Uveitis developed at a median interval of 0.8 (range - 4.7 to 9.4) years after onset of arthritis. Predictors of uveitis were age <7 years at JIA onset (Odds ratio (OR) 2.1, 95% confidence interval (CI) 1.3 to 3.5), presence of antihistone antibodies (AHA) > 15 U/ml (OR 4.8 (1.8 to 13.4)) and antinuclear antibodies (ANA) (OR 2.4 (1.5 to 4.0)). Mean combined IgM/IgG AHA was significantly higher in the uveitis group (19.2 U/ml) than in the non-uveitis group (10.2 U/ml) (p = 0.002). Young age at JIA onset predicted uveitis in girls (p <0.001), but not in boys (p = 0.390). Conclusion: Early-onset arthritis and presence of AHA in girls, as well as presence of ANA in both genders, were significant predictors of chronic uveitis. The high incidence of uveitis in this long-term Nordic JIA cohort may have severe implications in a lifelong perspective. Peer reviewed |
author2 |
Children's Hospital University of Helsinki Clinicum HUS Children and Adolescents |
format |
Article in Journal/Newspaper |
author |
Nordal, Ellen Rypdal, Veronika Christoffersen, Terje Aalto, Kristiina Berntson, Lillemor Fasth, Anders Herlin, Troels Nielsen, Susan Peltoniemi, Suvi Straume, Bjorn Zak, Marek Rygg, Marite Nordic Study Grp Pediat Rheumatolo |
author_facet |
Nordal, Ellen Rypdal, Veronika Christoffersen, Terje Aalto, Kristiina Berntson, Lillemor Fasth, Anders Herlin, Troels Nielsen, Susan Peltoniemi, Suvi Straume, Bjorn Zak, Marek Rygg, Marite Nordic Study Grp Pediat Rheumatolo |
author_sort |
Nordal, Ellen |
title |
Incidence and predictors of Uveitis in juvenile idiopathic arthritis in a Nordic long-term cohort study |
title_short |
Incidence and predictors of Uveitis in juvenile idiopathic arthritis in a Nordic long-term cohort study |
title_full |
Incidence and predictors of Uveitis in juvenile idiopathic arthritis in a Nordic long-term cohort study |
title_fullStr |
Incidence and predictors of Uveitis in juvenile idiopathic arthritis in a Nordic long-term cohort study |
title_full_unstemmed |
Incidence and predictors of Uveitis in juvenile idiopathic arthritis in a Nordic long-term cohort study |
title_sort |
incidence and predictors of uveitis in juvenile idiopathic arthritis in a nordic long-term cohort study |
publisher |
BioMed Central Ltd |
publishDate |
2017 |
url |
http://hdl.handle.net/10138/224273 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Arctic Northern Norway |
genre_facet |
Arctic Northern Norway |
op_relation |
10.1186/s12969-017-0195-8 This work was supported by grants from the Helse Nord Research Program, and the Grete Harbitz foundation. UiT the Arctic University of Norway funded the publication costs. Nordal , E , Rypdal , V , Christoffersen , T , Aalto , K , Berntson , L , Fasth , A , Herlin , T , Nielsen , S , Peltoniemi , S , Straume , B , Zak , M , Rygg , M & Nordic Study Grp Pediat Rheumatolo 2017 , ' Incidence and predictors of Uveitis in juvenile idiopathic arthritis in a Nordic long-term cohort study ' , Pediatric Rheumatology Online Journal , vol. 15 , 66 . https://doi.org/10.1186/s12969-017-0195-8 85027528899 e69bd663-23ba-4599-a1bd-cb47239b403e http://hdl.handle.net/10138/224273 000408003800001 |
op_rights |
cc_by openAccess info:eu-repo/semantics/openAccess |
container_title |
Pediatric Rheumatology |
container_volume |
15 |
container_issue |
1 |
_version_ |
1787421542711296000 |