Positional cloning and pathway analysis of the asthma susceptibility gene, NPSR1

• Main Author: Vendelin, Johanna
• Other Authors: von Mutius, Erika, University of Helsinki, Faculty of Biosciences, Department of Biological and Environmental Sciences, Biochemistry, Department of Medical Genetics, Faculty of Medicine, University of Helsinki, Helsingin yliopisto, biotieteellinen tiedekunta, bio- ja ympäristötieteiden laitos, Helsingfors universitet, biovetenskapliga fakulteten, institutionen för bio- och miljövetenskaper, Kere, Juha, Pirskanen, Asta
• Format: Doctoral or Postdoctoral Thesis
• Language: English
• Published: Helsingin yliopisto 2010
• Subjects: lääketiede; Canada; Kainuu; karelia*
• Online Access: http://hdl.handle.net/10138/22389

In the present study, we identified a novel asthma susceptibility gene, NPSR1 (neuropeptide S receptor 1) on chromosome 7p14.3 by the positional cloning strategy. An earlier significant linkage mapping result among Finnish Kainuu asthma families was confirmed in two independent cohorts: in asthma fa...