Living on the edge : Population genetics of Finno-Ugric-speaking humans in North Eurasia
The major aim of this thesis was to examine the origins and distribution of uniparental and autosomal genetic variation among the Finno-Ugric-speaking human populations living in Boreal and Arctic regions of North Eurasia. In more detail, I aimed to disentangle the underlying molecular and populatio...
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/20330 2023-08-20T04:04:58+02:00 Living on the edge : Population genetics of Finno-Ugric-speaking humans in North Eurasia Suomalais-ugrilaisia kieliä puhuvien väestöjen geneettinen monimuotoisuus Pimenoff, Ville Quintana-Murci, Lluis University of Helsinki, Faculty of Medicine, Department of Forensic Medicine Departament de Ciencies de la Salut i de la Vida, Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, Barcelona, Spain Helsingin yliopisto, lääketieteellinen tiedekunta, oikeuslääketieteen laitos Helsingfors universitet, medicinska fakulteten, institutionen för rättsmedicin Sajantila, Antti Comas, David 2010-11-25T11:21:37Z application/pdf http://hdl.handle.net/10138/20330 eng eng Helsingin yliopisto Helsingfors universitet University of Helsinki URN:ISBN:978-952-92-4331-0 Yliopistopaino: 2008 http://hdl.handle.net/10138/20330 URN:ISBN:978-952-10-4913-2 Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty. This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited. Publikationen är skyddad av upphovsrätten. Den får läsas och skrivas ut för personligt bruk. Användning i kommersiellt syfte är förbjuden. populaatiogenetiikka Text Doctoral dissertation (article-based) Artikkeliväitöskirja Artikelavhandling doctoralThesis 2010 ftunivhelsihelda 2023-07-28T06:09:40Z The major aim of this thesis was to examine the origins and distribution of uniparental and autosomal genetic variation among the Finno-Ugric-speaking human populations living in Boreal and Arctic regions of North Eurasia. In more detail, I aimed to disentangle the underlying molecular and population genetic factors which have produced the patterns of uniparental and autosomal genetic diversity in these populations. Among Finno-Ugrics the genetic amalgamation and clinal distribution of West and East Eurasian gene pools were observed within uniparental markers. This admixture indicates that North Eurasia was colonized through Central Asia/ South Siberia by human groups already carrying both West and East Eurasian lineages. The complex combination of founder effects, gene flow and genetic drift underlying the genetic diversity of the Finno-Ugric- speaking populations were emphasized by low haplotype diversity within and among uniparental and biparental markers. A high prevalence of lactase persistence allele among the North Eurasian Finno- Ugric agriculturalist populations was also shown indicating a local adaptation to subsistence change with lactose rich diet. Moreover, the haplotype background of lactase persistence allele among the Finno- Ugric-speakers strongly suggested that the lactase persistence T-13910 mutation was introduced independently more than once to the North Eurasian gene pool. A significant difference in genetic diversity, haplotype structure and LD distribution within the cytochrome P450 CYP2C and CYP2D regions revealed the unique gene pool of the Finno-Ugric Saami created mainly by population genetic processes compared to other Europeans and sub-Saharan Mandenka population. From all studied populations the Saami showed also significantly the highest allele frequency of a CYP2C19 gene mutation causing variable drug reactions. The diversity patterns observed within CYP2C and CYP2D regions emphasize the strong effect of demographic history shaping genetic diversity and LD especially among such ... Doctoral or Postdoctoral Thesis Arctic saami Siberia Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto Arctic |
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Open Polar |
collection |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
op_collection_id |
ftunivhelsihelda |
language |
English |
topic |
populaatiogenetiikka |
spellingShingle |
populaatiogenetiikka Pimenoff, Ville Living on the edge : Population genetics of Finno-Ugric-speaking humans in North Eurasia |
topic_facet |
populaatiogenetiikka |
description |
The major aim of this thesis was to examine the origins and distribution of uniparental and autosomal genetic variation among the Finno-Ugric-speaking human populations living in Boreal and Arctic regions of North Eurasia. In more detail, I aimed to disentangle the underlying molecular and population genetic factors which have produced the patterns of uniparental and autosomal genetic diversity in these populations. Among Finno-Ugrics the genetic amalgamation and clinal distribution of West and East Eurasian gene pools were observed within uniparental markers. This admixture indicates that North Eurasia was colonized through Central Asia/ South Siberia by human groups already carrying both West and East Eurasian lineages. The complex combination of founder effects, gene flow and genetic drift underlying the genetic diversity of the Finno-Ugric- speaking populations were emphasized by low haplotype diversity within and among uniparental and biparental markers. A high prevalence of lactase persistence allele among the North Eurasian Finno- Ugric agriculturalist populations was also shown indicating a local adaptation to subsistence change with lactose rich diet. Moreover, the haplotype background of lactase persistence allele among the Finno- Ugric-speakers strongly suggested that the lactase persistence T-13910 mutation was introduced independently more than once to the North Eurasian gene pool. A significant difference in genetic diversity, haplotype structure and LD distribution within the cytochrome P450 CYP2C and CYP2D regions revealed the unique gene pool of the Finno-Ugric Saami created mainly by population genetic processes compared to other Europeans and sub-Saharan Mandenka population. From all studied populations the Saami showed also significantly the highest allele frequency of a CYP2C19 gene mutation causing variable drug reactions. The diversity patterns observed within CYP2C and CYP2D regions emphasize the strong effect of demographic history shaping genetic diversity and LD especially among such ... |
author2 |
Quintana-Murci, Lluis University of Helsinki, Faculty of Medicine, Department of Forensic Medicine Departament de Ciencies de la Salut i de la Vida, Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, Barcelona, Spain Helsingin yliopisto, lääketieteellinen tiedekunta, oikeuslääketieteen laitos Helsingfors universitet, medicinska fakulteten, institutionen för rättsmedicin Sajantila, Antti Comas, David |
format |
Doctoral or Postdoctoral Thesis |
author |
Pimenoff, Ville |
author_facet |
Pimenoff, Ville |
author_sort |
Pimenoff, Ville |
title |
Living on the edge : Population genetics of Finno-Ugric-speaking humans in North Eurasia |
title_short |
Living on the edge : Population genetics of Finno-Ugric-speaking humans in North Eurasia |
title_full |
Living on the edge : Population genetics of Finno-Ugric-speaking humans in North Eurasia |
title_fullStr |
Living on the edge : Population genetics of Finno-Ugric-speaking humans in North Eurasia |
title_full_unstemmed |
Living on the edge : Population genetics of Finno-Ugric-speaking humans in North Eurasia |
title_sort |
living on the edge : population genetics of finno-ugric-speaking humans in north eurasia |
publisher |
Helsingin yliopisto |
publishDate |
2010 |
url |
http://hdl.handle.net/10138/20330 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic saami Siberia |
genre_facet |
Arctic saami Siberia |
op_relation |
URN:ISBN:978-952-92-4331-0 Yliopistopaino: 2008 http://hdl.handle.net/10138/20330 URN:ISBN:978-952-10-4913-2 |
op_rights |
Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty. This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited. Publikationen är skyddad av upphovsrätten. Den får läsas och skrivas ut för personligt bruk. Användning i kommersiellt syfte är förbjuden. |
_version_ |
1774715385771196416 |