Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP)
Fur Animal Epidemic Necrotic Pyoderma (FENP) is a severe, often lethal infectious disease affecting all three fur animal species: mink (Neovision vision), foxes (Vulpes lagopus) and finnraccoons (Nyctereutes procyonoides). Previous studies showed an association between Arcanobacterium phocae and FEN...
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/174570 2024-01-07T09:47:13+01:00 Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP) Nordgren, Heli Aaltonen, Kirsi Raunio-Saarnisto, Mirja Sukura, Antti Vapalahti, Olli Sironen, Tarja Veterinary Biosciences Medicum Department of Virology Clinicum Viral Zoonosis Research Unit Emerging Infections Research Group 2017-02-02T14:29:02Z 13 application/pdf http://hdl.handle.net/10138/174570 eng eng PUBLIC LIBRARY OF SCIENCE 10.1371/journal.pone.0168129 Nordgren , H , Aaltonen , K , Raunio-Saarnisto , M , Sukura , A , Vapalahti , O & Sironen , T 2016 , ' Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP) ' , PLoS One , vol. 11 , no. 12 , 0168129 , pp. 1-13 . https://doi.org/10.1371/journal.pone.0168129 Bibtex: urn:fb7ff00a2b390255348fadb187d86147 ORCID: /0000-0002-2344-2755/work/43226607 ORCID: /0000-0003-2270-6824/work/30029294 ORCID: /0000-0001-8901-6866/work/30030547 ORCID: /0000-0002-8992-1695/work/75942738 85006165327 3b875726-0fe3-49df-8755-c1f8b3e148f7 http://hdl.handle.net/10138/174570 000392754300058 cc_by openAccess info:eu-repo/semantics/openAccess 413 Veterinary science Article publishedVersion 2017 ftunivhelsihelda 2023-12-14T00:10:03Z Fur Animal Epidemic Necrotic Pyoderma (FENP) is a severe, often lethal infectious disease affecting all three fur animal species: mink (Neovision vision), foxes (Vulpes lagopus) and finnraccoons (Nyctereutes procyonoides). Previous studies showed an association between Arcanobacterium phocae and FENP. An experimental infection was conducted to confirm the ability of A. phocae to infect mink either alone or concurrently with a novel Streptococcus sp. found together with A. phocae in many cases of FENP. Different inoculation methods were tested to study possible routes of transmission. Typical signs, and gross- and histopathological findings for FENP were detected when naïve mink were infected with the tissue extract of mink with FENP, using a subcutaneous/ intradermal infection route. Edema, hemorrhage, necrosis and pus formation were detected in the infection site. A pure culture preparation of A. phocae alone or concurrently with the novel Streptococcus sp. caused severe acute signs of lethargy, apathy and anorexia and even mortality. The histopathological findings were similar to those found in naturally occurring cases of FENP. In contrast, the perorally infected mink presented no clinical signs nor any gross- or histopathological lesions. This study showed that A. phocae is able to cause FENP. The study also indicated that predisposing factors such as the environment, the general condition of the animals, temperature and skin trauma contribute to the development of the disease. Peer reviewed Article in Journal/Newspaper Vulpes lagopus HELDA – University of Helsinki Open Repository PLOS ONE 11 12 e0168129 |
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HELDA – University of Helsinki Open Repository |
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ftunivhelsihelda |
language |
English |
topic |
413 Veterinary science |
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413 Veterinary science Nordgren, Heli Aaltonen, Kirsi Raunio-Saarnisto, Mirja Sukura, Antti Vapalahti, Olli Sironen, Tarja Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP) |
topic_facet |
413 Veterinary science |
description |
Fur Animal Epidemic Necrotic Pyoderma (FENP) is a severe, often lethal infectious disease affecting all three fur animal species: mink (Neovision vision), foxes (Vulpes lagopus) and finnraccoons (Nyctereutes procyonoides). Previous studies showed an association between Arcanobacterium phocae and FENP. An experimental infection was conducted to confirm the ability of A. phocae to infect mink either alone or concurrently with a novel Streptococcus sp. found together with A. phocae in many cases of FENP. Different inoculation methods were tested to study possible routes of transmission. Typical signs, and gross- and histopathological findings for FENP were detected when naïve mink were infected with the tissue extract of mink with FENP, using a subcutaneous/ intradermal infection route. Edema, hemorrhage, necrosis and pus formation were detected in the infection site. A pure culture preparation of A. phocae alone or concurrently with the novel Streptococcus sp. caused severe acute signs of lethargy, apathy and anorexia and even mortality. The histopathological findings were similar to those found in naturally occurring cases of FENP. In contrast, the perorally infected mink presented no clinical signs nor any gross- or histopathological lesions. This study showed that A. phocae is able to cause FENP. The study also indicated that predisposing factors such as the environment, the general condition of the animals, temperature and skin trauma contribute to the development of the disease. Peer reviewed |
author2 |
Veterinary Biosciences Medicum Department of Virology Clinicum Viral Zoonosis Research Unit Emerging Infections Research Group |
format |
Article in Journal/Newspaper |
author |
Nordgren, Heli Aaltonen, Kirsi Raunio-Saarnisto, Mirja Sukura, Antti Vapalahti, Olli Sironen, Tarja |
author_facet |
Nordgren, Heli Aaltonen, Kirsi Raunio-Saarnisto, Mirja Sukura, Antti Vapalahti, Olli Sironen, Tarja |
author_sort |
Nordgren, Heli |
title |
Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP) |
title_short |
Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP) |
title_full |
Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP) |
title_fullStr |
Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP) |
title_full_unstemmed |
Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP) |
title_sort |
experimental infection of mink enforces the role of arcanobacterium phocae as causative agent of fur animal epidemic necrotic pyoderma (fenp) |
publisher |
PUBLIC LIBRARY OF SCIENCE |
publishDate |
2017 |
url |
http://hdl.handle.net/10138/174570 |
genre |
Vulpes lagopus |
genre_facet |
Vulpes lagopus |
op_relation |
10.1371/journal.pone.0168129 Nordgren , H , Aaltonen , K , Raunio-Saarnisto , M , Sukura , A , Vapalahti , O & Sironen , T 2016 , ' Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP) ' , PLoS One , vol. 11 , no. 12 , 0168129 , pp. 1-13 . https://doi.org/10.1371/journal.pone.0168129 Bibtex: urn:fb7ff00a2b390255348fadb187d86147 ORCID: /0000-0002-2344-2755/work/43226607 ORCID: /0000-0003-2270-6824/work/30029294 ORCID: /0000-0001-8901-6866/work/30030547 ORCID: /0000-0002-8992-1695/work/75942738 85006165327 3b875726-0fe3-49df-8755-c1f8b3e148f7 http://hdl.handle.net/10138/174570 000392754300058 |
op_rights |
cc_by openAccess info:eu-repo/semantics/openAccess |
container_title |
PLOS ONE |
container_volume |
11 |
container_issue |
12 |
container_start_page |
e0168129 |
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