Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia
Background: Atopic allergy is much more common in Finnish compared with Russian Karelia, although these areas are geographically and genetically close. To explore the role of environmental chemicals on the atopy difference a random sample of 200 individuals, 25 atopic and 25 non-atopic school-aged c...
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/173636 2024-01-07T09:44:29+01:00 Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia Koskinen, Jyri-Pekka Kiviranta, Hannu Vartiainen, Erkki Jousilahti, Pekka Vlasoff, Tiina von Hertzen, Leena Mäkelä, Mika Laatikainen, Tiina Haahtela, Tari Department of Dermatology, Allergology and Venereology Clinicum 2017-01-17T10:20:03Z 4 application/pdf http://hdl.handle.net/10138/173636 eng eng BMC 10.1186/s13601-016-0103-1 The Karelia study was financed by Academy of Finland (Grant No. 138932), European Commission Seventh Framework Programme (Grant No. 261357, MeDALL), and Helsinki University Hospital (HUS) (Grant No. 8361). Koskinen , J-P , Kiviranta , H , Vartiainen , E , Jousilahti , P , Vlasoff , T , von Hertzen , L , Mäkelä , M , Laatikainen , T & Haahtela , T 2016 , ' Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia ' , Clinical and Translational Allergy , vol. 6 , 14 . https://doi.org/10.1186/s13601-016-0103-1 ORCID: /0000-0002-2933-3111/work/29548321 85006304558 1f804684-1b32-4914-9ef7-4f5bf4180e35 http://hdl.handle.net/10138/173636 000390114800001 cc_by openAccess info:eu-repo/semantics/openAccess Allergy Atopy Environmental chemicals Finnish Karelia Russian Karelia PERSISTENT ORGANIC POLLUTANTS PRENATAL EXPOSURE CHILDREN ASTHMA 3121 General medicine internal medicine and other clinical medicine Article publishedVersion 2017 ftunivhelsihelda 2023-12-14T00:05:30Z Background: Atopic allergy is much more common in Finnish compared with Russian Karelia, although these areas are geographically and genetically close. To explore the role of environmental chemicals on the atopy difference a random sample of 200 individuals, 25 atopic and 25 non-atopic school-aged children and their mothers, were studied. Atopy was defined as having at least one positive skin prick test response to 14 common inhalant and food allergens tested. Concentrations of 11 common environmental pollutants were measured in blood samples. Results: Overall, the chemical levels were much higher in Russia than in Finland, except for 2,2', 4,4'-tetra-bromodiphenyl ether (BDE47). In Finland but not in Russia, the atopic children had higher concentrations of polychlorinated biphenyls and 1,1-Dichloro-2,2-bis-(p-chlorophenyl)-ethylene (DDE) than the non-atopic children. In Russia but not in Finland, the atopic mothers had higher DDE concentrations than the non-atopic mothers. Conclusions: Higher concentrations of common environmental chemicals were measured in Russian compared with Finnish Karelian children and mothers. The chemicals did not explain the higher prevalence of atopy on the Finnish side. Peer reviewed Article in Journal/Newspaper karelia* karelia* karelian HELDA – University of Helsinki Open Repository Clinical and Translational Allergy 6 1 |
institution |
Open Polar |
collection |
HELDA – University of Helsinki Open Repository |
op_collection_id |
ftunivhelsihelda |
language |
English |
topic |
Allergy Atopy Environmental chemicals Finnish Karelia Russian Karelia PERSISTENT ORGANIC POLLUTANTS PRENATAL EXPOSURE CHILDREN ASTHMA 3121 General medicine internal medicine and other clinical medicine |
spellingShingle |
Allergy Atopy Environmental chemicals Finnish Karelia Russian Karelia PERSISTENT ORGANIC POLLUTANTS PRENATAL EXPOSURE CHILDREN ASTHMA 3121 General medicine internal medicine and other clinical medicine Koskinen, Jyri-Pekka Kiviranta, Hannu Vartiainen, Erkki Jousilahti, Pekka Vlasoff, Tiina von Hertzen, Leena Mäkelä, Mika Laatikainen, Tiina Haahtela, Tari Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia |
topic_facet |
Allergy Atopy Environmental chemicals Finnish Karelia Russian Karelia PERSISTENT ORGANIC POLLUTANTS PRENATAL EXPOSURE CHILDREN ASTHMA 3121 General medicine internal medicine and other clinical medicine |
description |
Background: Atopic allergy is much more common in Finnish compared with Russian Karelia, although these areas are geographically and genetically close. To explore the role of environmental chemicals on the atopy difference a random sample of 200 individuals, 25 atopic and 25 non-atopic school-aged children and their mothers, were studied. Atopy was defined as having at least one positive skin prick test response to 14 common inhalant and food allergens tested. Concentrations of 11 common environmental pollutants were measured in blood samples. Results: Overall, the chemical levels were much higher in Russia than in Finland, except for 2,2', 4,4'-tetra-bromodiphenyl ether (BDE47). In Finland but not in Russia, the atopic children had higher concentrations of polychlorinated biphenyls and 1,1-Dichloro-2,2-bis-(p-chlorophenyl)-ethylene (DDE) than the non-atopic children. In Russia but not in Finland, the atopic mothers had higher DDE concentrations than the non-atopic mothers. Conclusions: Higher concentrations of common environmental chemicals were measured in Russian compared with Finnish Karelian children and mothers. The chemicals did not explain the higher prevalence of atopy on the Finnish side. Peer reviewed |
author2 |
Department of Dermatology, Allergology and Venereology Clinicum |
format |
Article in Journal/Newspaper |
author |
Koskinen, Jyri-Pekka Kiviranta, Hannu Vartiainen, Erkki Jousilahti, Pekka Vlasoff, Tiina von Hertzen, Leena Mäkelä, Mika Laatikainen, Tiina Haahtela, Tari |
author_facet |
Koskinen, Jyri-Pekka Kiviranta, Hannu Vartiainen, Erkki Jousilahti, Pekka Vlasoff, Tiina von Hertzen, Leena Mäkelä, Mika Laatikainen, Tiina Haahtela, Tari |
author_sort |
Koskinen, Jyri-Pekka |
title |
Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia |
title_short |
Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia |
title_full |
Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia |
title_fullStr |
Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia |
title_full_unstemmed |
Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia |
title_sort |
common environmental chemicals do not explain atopy contrast in the finnish and russian karelia |
publisher |
BMC |
publishDate |
2017 |
url |
http://hdl.handle.net/10138/173636 |
genre |
karelia* karelia* karelian |
genre_facet |
karelia* karelia* karelian |
op_relation |
10.1186/s13601-016-0103-1 The Karelia study was financed by Academy of Finland (Grant No. 138932), European Commission Seventh Framework Programme (Grant No. 261357, MeDALL), and Helsinki University Hospital (HUS) (Grant No. 8361). Koskinen , J-P , Kiviranta , H , Vartiainen , E , Jousilahti , P , Vlasoff , T , von Hertzen , L , Mäkelä , M , Laatikainen , T & Haahtela , T 2016 , ' Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia ' , Clinical and Translational Allergy , vol. 6 , 14 . https://doi.org/10.1186/s13601-016-0103-1 ORCID: /0000-0002-2933-3111/work/29548321 85006304558 1f804684-1b32-4914-9ef7-4f5bf4180e35 http://hdl.handle.net/10138/173636 000390114800001 |
op_rights |
cc_by openAccess info:eu-repo/semantics/openAccess |
container_title |
Clinical and Translational Allergy |
container_volume |
6 |
container_issue |
1 |
_version_ |
1787425886536990720 |