Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia
Abstract Background Atopic allergy is much more common in Finnish compared with Russian Karelia, although these areas are geographically and genetically close. To explore the role of environmental chemicals on the atopy difference a random sample of 200 individuals, 25 atopic and 25 non-atopic schoo...
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/161073 2023-08-20T04:07:41+02:00 Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia Koskinen, Jyri-Pekka Kiviranta, Hannu Vartiainen, Erkki Jousilahti, Pekka Vlasoff, Tiina von Hertzen, Leena Mäkelä, Mika Laatikainen, Tiina Haahtela, Tari 2016-04-04T03:24:20Z application/pdf http://hdl.handle.net/10138/161073 eng eng BioMed Central Clinical and Translational Allergy. 2016 Apr 04;6(1):14 http://hdl.handle.net/10138/161073 Koskinen et al. http://purl.org/eprint/entityType/ScholarlyWork http://purl.org/eprint/entityType/Expression http://purl.org/eprint/type/JournalArticle 2016 ftunivhelsihelda 2023-07-28T06:26:54Z Abstract Background Atopic allergy is much more common in Finnish compared with Russian Karelia, although these areas are geographically and genetically close. To explore the role of environmental chemicals on the atopy difference a random sample of 200 individuals, 25 atopic and 25 non-atopic school-aged children and their mothers, were studied. Atopy was defined as having at least one positive skin prick test response to 14 common inhalant and food allergens tested. Concentrations of 11 common environmental pollutants were measured in blood samples. Results Overall, the chemical levels were much higher in Russia than in Finland, except for 2,2′,4,4′-tetra-bromodiphenyl ether (BDE47). In Finland but not in Russia, the atopic children had higher concentrations of polychlorinated biphenyls and 1,1-Dichloro-2,2-bis-(p-chlorophenyl)-ethylene (DDE) than the non-atopic children. In Russia but not in Finland, the atopic mothers had higher DDE concentrations than the non-atopic mothers. Conclusions Higher concentrations of common environmental chemicals were measured in Russian compared with Finnish Karelian children and mothers. The chemicals did not explain the higher prevalence of atopy on the Finnish side. Article in Journal/Newspaper karelia* karelia* karelian Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
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Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
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ftunivhelsihelda |
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English |
description |
Abstract Background Atopic allergy is much more common in Finnish compared with Russian Karelia, although these areas are geographically and genetically close. To explore the role of environmental chemicals on the atopy difference a random sample of 200 individuals, 25 atopic and 25 non-atopic school-aged children and their mothers, were studied. Atopy was defined as having at least one positive skin prick test response to 14 common inhalant and food allergens tested. Concentrations of 11 common environmental pollutants were measured in blood samples. Results Overall, the chemical levels were much higher in Russia than in Finland, except for 2,2′,4,4′-tetra-bromodiphenyl ether (BDE47). In Finland but not in Russia, the atopic children had higher concentrations of polychlorinated biphenyls and 1,1-Dichloro-2,2-bis-(p-chlorophenyl)-ethylene (DDE) than the non-atopic children. In Russia but not in Finland, the atopic mothers had higher DDE concentrations than the non-atopic mothers. Conclusions Higher concentrations of common environmental chemicals were measured in Russian compared with Finnish Karelian children and mothers. The chemicals did not explain the higher prevalence of atopy on the Finnish side. |
format |
Article in Journal/Newspaper |
author |
Koskinen, Jyri-Pekka Kiviranta, Hannu Vartiainen, Erkki Jousilahti, Pekka Vlasoff, Tiina von Hertzen, Leena Mäkelä, Mika Laatikainen, Tiina Haahtela, Tari |
spellingShingle |
Koskinen, Jyri-Pekka Kiviranta, Hannu Vartiainen, Erkki Jousilahti, Pekka Vlasoff, Tiina von Hertzen, Leena Mäkelä, Mika Laatikainen, Tiina Haahtela, Tari Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia |
author_facet |
Koskinen, Jyri-Pekka Kiviranta, Hannu Vartiainen, Erkki Jousilahti, Pekka Vlasoff, Tiina von Hertzen, Leena Mäkelä, Mika Laatikainen, Tiina Haahtela, Tari |
author_sort |
Koskinen, Jyri-Pekka |
title |
Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia |
title_short |
Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia |
title_full |
Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia |
title_fullStr |
Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia |
title_full_unstemmed |
Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia |
title_sort |
common environmental chemicals do not explain atopy contrast in the finnish and russian karelia |
publisher |
BioMed Central |
publishDate |
2016 |
url |
http://hdl.handle.net/10138/161073 |
genre |
karelia* karelia* karelian |
genre_facet |
karelia* karelia* karelian |
op_relation |
Clinical and Translational Allergy. 2016 Apr 04;6(1):14 http://hdl.handle.net/10138/161073 |
op_rights |
Koskinen et al. |
_version_ |
1774719501951041536 |