A study of genes encoding cytokines ( IL6 , IL10 , TNF ), cytokine receptors ( IL6R , IL6ST ), and glucocorticoid receptor ( NR3C1 ) and susceptibility to bronchopulmonary dysplasia
Abstract Background Bronchopulmonary dysplasia (BPD) is a common chronic lung disease associated with very preterm birth. The major risk factors include lung inflammation and lung immaturity. In addition, genetic factors play an important role in susceptibility to moderate-to-severe BPD. In this stu...
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ftunivhelsihelda:oai:helda.helsinki.fi:10138/144113 2023-08-20T04:08:44+02:00 A study of genes encoding cytokines ( IL6 , IL10 , TNF ), cytokine receptors ( IL6R , IL6ST ), and glucocorticoid receptor ( NR3C1 ) and susceptibility to bronchopulmonary dysplasia Huusko, Johanna M Karjalainen, Minna K Mahlman, Mari Haataja, Ritva Kari, M A Andersson, Sture Toldi, Gergely Tammela, Outi Rämet, Mika Lavoie, Pascal M Hallman, Mikko on behalf of Gen-BPD Study Group 2014-11-19T20:03:42Z text/xml application/pdf http://hdl.handle.net/10138/144113 eng eng BioMed Central Ltd BMC Medical Genetics. 2014 Nov 01;15(1):120 http://hdl.handle.net/10138/144113 CC BY 4.0 openAccess Johanna M Huusko et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 http://purl.org/eprint/entityType/ScholarlyWork http://purl.org/eprint/entityType/Expression http://purl.org/eprint/type/JournalArticle 2014 ftunivhelsihelda 2023-07-28T06:22:15Z Abstract Background Bronchopulmonary dysplasia (BPD) is a common chronic lung disease associated with very preterm birth. The major risk factors include lung inflammation and lung immaturity. In addition, genetic factors play an important role in susceptibility to moderate-to-severe BPD. In this study, the aim was to investigate whether common polymorphisms of specific genes that are involved in inflammation or differentiation of the lung have influence on BPD susceptibility. Methods Genes encoding interleukin-6 (IL6) and its receptors (IL6R and IL6ST), IL-10 (IL10), tumor necrosis factor (TNF), and glucocorticoid receptor (NR3C1) were assessed for associations with moderate-to-severe BPD susceptibility. Five IL6, nine IL6R, four IL6ST, one IL10, two TNF, and 23 NR3C1 single nucleotide polymorphisms (SNPs) were analyzed in very preterm infants born in northern Finland (56 cases and 197 controls) and Canada (58 cases and 68 controls). IL-6, TNF and gp130 contents in umbilical cord blood, collected from very preterm infants, were studied for associations with the polymorphisms. Epistasis (i.e., interactions between SNPs in BPD susceptibility) was also examined. SNPs showing suggestive associations were analyzed in additional replication populations from Finland (39 cases and 188 controls) and Hungary (29 cases and 40 controls). Results None of the studied SNPs were associated with BPD nor were the IL6, TNF or IL6ST SNPs associated with cord blood IL-6, TNF and gp130, respectively. However, epistasis analysis suggested that SNPs in IL6ST and IL10 were associated interactively with risk of BPD in the northern Finnish population; however, this finding did not remain significant after correction for multiple testing and the finding was not replicated in the other populations. Conclusions We conclude that the analyzed SNPs within IL6, IL6R, IL6ST, IL10, TNF, and NR3C1 were not associated with BPD. Furthermore, there was no evidence that the studied SNPs directly contribute to the cord blood protein contents. Article in Journal/Newspaper Northern Finland Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto Canada |
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Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
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ftunivhelsihelda |
language |
English |
description |
Abstract Background Bronchopulmonary dysplasia (BPD) is a common chronic lung disease associated with very preterm birth. The major risk factors include lung inflammation and lung immaturity. In addition, genetic factors play an important role in susceptibility to moderate-to-severe BPD. In this study, the aim was to investigate whether common polymorphisms of specific genes that are involved in inflammation or differentiation of the lung have influence on BPD susceptibility. Methods Genes encoding interleukin-6 (IL6) and its receptors (IL6R and IL6ST), IL-10 (IL10), tumor necrosis factor (TNF), and glucocorticoid receptor (NR3C1) were assessed for associations with moderate-to-severe BPD susceptibility. Five IL6, nine IL6R, four IL6ST, one IL10, two TNF, and 23 NR3C1 single nucleotide polymorphisms (SNPs) were analyzed in very preterm infants born in northern Finland (56 cases and 197 controls) and Canada (58 cases and 68 controls). IL-6, TNF and gp130 contents in umbilical cord blood, collected from very preterm infants, were studied for associations with the polymorphisms. Epistasis (i.e., interactions between SNPs in BPD susceptibility) was also examined. SNPs showing suggestive associations were analyzed in additional replication populations from Finland (39 cases and 188 controls) and Hungary (29 cases and 40 controls). Results None of the studied SNPs were associated with BPD nor were the IL6, TNF or IL6ST SNPs associated with cord blood IL-6, TNF and gp130, respectively. However, epistasis analysis suggested that SNPs in IL6ST and IL10 were associated interactively with risk of BPD in the northern Finnish population; however, this finding did not remain significant after correction for multiple testing and the finding was not replicated in the other populations. Conclusions We conclude that the analyzed SNPs within IL6, IL6R, IL6ST, IL10, TNF, and NR3C1 were not associated with BPD. Furthermore, there was no evidence that the studied SNPs directly contribute to the cord blood protein contents. |
format |
Article in Journal/Newspaper |
author |
Huusko, Johanna M Karjalainen, Minna K Mahlman, Mari Haataja, Ritva Kari, M A Andersson, Sture Toldi, Gergely Tammela, Outi Rämet, Mika Lavoie, Pascal M Hallman, Mikko on behalf of Gen-BPD Study Group |
spellingShingle |
Huusko, Johanna M Karjalainen, Minna K Mahlman, Mari Haataja, Ritva Kari, M A Andersson, Sture Toldi, Gergely Tammela, Outi Rämet, Mika Lavoie, Pascal M Hallman, Mikko on behalf of Gen-BPD Study Group A study of genes encoding cytokines ( IL6 , IL10 , TNF ), cytokine receptors ( IL6R , IL6ST ), and glucocorticoid receptor ( NR3C1 ) and susceptibility to bronchopulmonary dysplasia |
author_facet |
Huusko, Johanna M Karjalainen, Minna K Mahlman, Mari Haataja, Ritva Kari, M A Andersson, Sture Toldi, Gergely Tammela, Outi Rämet, Mika Lavoie, Pascal M Hallman, Mikko on behalf of Gen-BPD Study Group |
author_sort |
Huusko, Johanna M |
title |
A study of genes encoding cytokines ( IL6 , IL10 , TNF ), cytokine receptors ( IL6R , IL6ST ), and glucocorticoid receptor ( NR3C1 ) and susceptibility to bronchopulmonary dysplasia |
title_short |
A study of genes encoding cytokines ( IL6 , IL10 , TNF ), cytokine receptors ( IL6R , IL6ST ), and glucocorticoid receptor ( NR3C1 ) and susceptibility to bronchopulmonary dysplasia |
title_full |
A study of genes encoding cytokines ( IL6 , IL10 , TNF ), cytokine receptors ( IL6R , IL6ST ), and glucocorticoid receptor ( NR3C1 ) and susceptibility to bronchopulmonary dysplasia |
title_fullStr |
A study of genes encoding cytokines ( IL6 , IL10 , TNF ), cytokine receptors ( IL6R , IL6ST ), and glucocorticoid receptor ( NR3C1 ) and susceptibility to bronchopulmonary dysplasia |
title_full_unstemmed |
A study of genes encoding cytokines ( IL6 , IL10 , TNF ), cytokine receptors ( IL6R , IL6ST ), and glucocorticoid receptor ( NR3C1 ) and susceptibility to bronchopulmonary dysplasia |
title_sort |
study of genes encoding cytokines ( il6 , il10 , tnf ), cytokine receptors ( il6r , il6st ), and glucocorticoid receptor ( nr3c1 ) and susceptibility to bronchopulmonary dysplasia |
publisher |
BioMed Central Ltd |
publishDate |
2014 |
url |
http://hdl.handle.net/10138/144113 |
geographic |
Canada |
geographic_facet |
Canada |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
BMC Medical Genetics. 2014 Nov 01;15(1):120 http://hdl.handle.net/10138/144113 |
op_rights |
CC BY 4.0 openAccess Johanna M Huusko et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 |
_version_ |
1774721185578221568 |