Evolutionary analysis and genetic mapping of neuropeptide Y (NPY) receptors in rainbow trout(Oncorhynchus mykiss) and Arctic charr (Salvelinus alpinus)
Neuropeptide Y (NPY) receptors are an important multifunctional gene family found in vertebrates characterized by a complex evolutionary history of gene duplication and loss. I genetically mapped and sequenced the NPY receptors in rainbow trout (Oncorhynchus mykiss) and Arctic charr (Salvelinus alpi...
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University of Guelph
2012
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ftunivguelph:oai:atrium.lib.uoguelph.ca:10214/4048 2024-06-23T07:48:54+00:00 Evolutionary analysis and genetic mapping of neuropeptide Y (NPY) receptors in rainbow trout(Oncorhynchus mykiss) and Arctic charr (Salvelinus alpinus) Goldt, Aaron Danzmann, Roy Ferguson, Moira 2012-10-03 text/plain application/pdf http://hdl.handle.net/10214/4048 en eng University of Guelph http://hdl.handle.net/10214/4048 Attribution-ShareAlike 2.5 Canada http://creativecommons.org/licenses/by-sa/2.5/ca/ rainbow trout (Oncorhynchus mykiss) Arctic charr (Salvelinus alpinus) gene duplication neuropeptide Y (NPY) Thesis 2012 ftunivguelph 2024-06-05T00:00:30Z Neuropeptide Y (NPY) receptors are an important multifunctional gene family found in vertebrates characterized by a complex evolutionary history of gene duplication and loss. I genetically mapped and sequenced the NPY receptors in rainbow trout (Oncorhynchus mykiss) and Arctic charr (Salvelinus alpinus) to examine the fate of this receptor family following the whole genome duplication in the salmonid ancestor. Based on receptors present in model teleosts, the Y1, Y2, Y4, Y7, Y8a and Y8b receptors were predicted to occur in the salmonid genome. Single copies of Y2, Y7 and Y8b and a tandem duplication of Y8a were detected in both rainbow trout and Arctic charr. Bayesian phylogenetic analysis strongly supports the model of NPY receptor evolution through multiple duplication events. The absence of multiple receptor subtypes and the presence of a tandem duplicate were unexpected but fall within patterns observed from previous duplication events. Natural Sciences and Engineering Research Council of Canada Thesis Arctic charr Arctic Salvelinus alpinus University of Guelph: DSpace digital archive Arctic Canada |
institution |
Open Polar |
collection |
University of Guelph: DSpace digital archive |
op_collection_id |
ftunivguelph |
language |
English |
topic |
rainbow trout (Oncorhynchus mykiss) Arctic charr (Salvelinus alpinus) gene duplication neuropeptide Y (NPY) |
spellingShingle |
rainbow trout (Oncorhynchus mykiss) Arctic charr (Salvelinus alpinus) gene duplication neuropeptide Y (NPY) Goldt, Aaron Evolutionary analysis and genetic mapping of neuropeptide Y (NPY) receptors in rainbow trout(Oncorhynchus mykiss) and Arctic charr (Salvelinus alpinus) |
topic_facet |
rainbow trout (Oncorhynchus mykiss) Arctic charr (Salvelinus alpinus) gene duplication neuropeptide Y (NPY) |
description |
Neuropeptide Y (NPY) receptors are an important multifunctional gene family found in vertebrates characterized by a complex evolutionary history of gene duplication and loss. I genetically mapped and sequenced the NPY receptors in rainbow trout (Oncorhynchus mykiss) and Arctic charr (Salvelinus alpinus) to examine the fate of this receptor family following the whole genome duplication in the salmonid ancestor. Based on receptors present in model teleosts, the Y1, Y2, Y4, Y7, Y8a and Y8b receptors were predicted to occur in the salmonid genome. Single copies of Y2, Y7 and Y8b and a tandem duplication of Y8a were detected in both rainbow trout and Arctic charr. Bayesian phylogenetic analysis strongly supports the model of NPY receptor evolution through multiple duplication events. The absence of multiple receptor subtypes and the presence of a tandem duplicate were unexpected but fall within patterns observed from previous duplication events. Natural Sciences and Engineering Research Council of Canada |
author2 |
Danzmann, Roy Ferguson, Moira |
format |
Thesis |
author |
Goldt, Aaron |
author_facet |
Goldt, Aaron |
author_sort |
Goldt, Aaron |
title |
Evolutionary analysis and genetic mapping of neuropeptide Y (NPY) receptors in rainbow trout(Oncorhynchus mykiss) and Arctic charr (Salvelinus alpinus) |
title_short |
Evolutionary analysis and genetic mapping of neuropeptide Y (NPY) receptors in rainbow trout(Oncorhynchus mykiss) and Arctic charr (Salvelinus alpinus) |
title_full |
Evolutionary analysis and genetic mapping of neuropeptide Y (NPY) receptors in rainbow trout(Oncorhynchus mykiss) and Arctic charr (Salvelinus alpinus) |
title_fullStr |
Evolutionary analysis and genetic mapping of neuropeptide Y (NPY) receptors in rainbow trout(Oncorhynchus mykiss) and Arctic charr (Salvelinus alpinus) |
title_full_unstemmed |
Evolutionary analysis and genetic mapping of neuropeptide Y (NPY) receptors in rainbow trout(Oncorhynchus mykiss) and Arctic charr (Salvelinus alpinus) |
title_sort |
evolutionary analysis and genetic mapping of neuropeptide y (npy) receptors in rainbow trout(oncorhynchus mykiss) and arctic charr (salvelinus alpinus) |
publisher |
University of Guelph |
publishDate |
2012 |
url |
http://hdl.handle.net/10214/4048 |
geographic |
Arctic Canada |
geographic_facet |
Arctic Canada |
genre |
Arctic charr Arctic Salvelinus alpinus |
genre_facet |
Arctic charr Arctic Salvelinus alpinus |
op_relation |
http://hdl.handle.net/10214/4048 |
op_rights |
Attribution-ShareAlike 2.5 Canada http://creativecommons.org/licenses/by-sa/2.5/ca/ |
_version_ |
1802639214595014656 |