Relation Between Methylmercury Exposure and Serum Paraoxonase Activity in Cree and Inuit Communities of Northern Québec
I7. Principal investigator: Pierre Ayotte Methylmercury (MeHg) exposure has been linked to an increased risk of cardiovascular diseases, in particular myocardial infarction. Paraoxonase 1 (PON1) is an enzyme located in the high density lipoprotein (HDL) fraction of blood lipids. It metabolizes toxic...
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ftunivguelph:oai:atrium.lib.uoguelph.ca:10214/2163 2023-11-05T03:43:03+01:00 Relation Between Methylmercury Exposure and Serum Paraoxonase Activity in Cree and Inuit Communities of Northern Québec Dewailley, Eric Ayotte, Pierre 2010-04-29T18:58:53Z application/pdf http://hdl.handle.net/10214/2163 en eng I;7 http://hdl.handle.net/10214/2163 All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated. Inuit communities Cree communities Cardiovascular diseases Methylmercury PON1 activity Other 2010 ftunivguelph 2023-10-08T06:10:31Z I7. Principal investigator: Pierre Ayotte Methylmercury (MeHg) exposure has been linked to an increased risk of cardiovascular diseases, in particular myocardial infarction. Paraoxonase 1 (PON1) is an enzyme located in the high density lipoprotein (HDL) fraction of blood lipids. It metabolizes toxic oxidized lipids associated with both low density liproprotein (LDL) and HDL. MeHg and various metals (Cd, Co, Cu, Fe, Mn, Ni, Zn) have been shown to inhibit PON1 activity in vitro but the relation between metal exposure and PON1 activity has not been studied in human populations. We hypothesize that mercury concentration in blood could be linked to decreased serum PON1 activity in populations highly exposed to methylmercury such as Aboriginal populations relying on fish for sustenance. PON1 activity will be determined in serum samples from participants to the Cree Health Survey who will be recruited in two Northern Quebec Cree communities to be visited in 2007. Associations between PON1 activity and metals will be tested, taking into consideration possible confounders. The influence of PON1 genotypes will be taken into consideration. In addition, we will examine possible relations between PON1 activity and the concentration of oxidized LDL, and the thickness of the carotid intima media. Metals in the Human Environment Strategic Network Other/Unknown Material inuit University of Guelph: DSpace digital archive |
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Open Polar |
collection |
University of Guelph: DSpace digital archive |
op_collection_id |
ftunivguelph |
language |
English |
topic |
Inuit communities Cree communities Cardiovascular diseases Methylmercury PON1 activity |
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Inuit communities Cree communities Cardiovascular diseases Methylmercury PON1 activity Dewailley, Eric Ayotte, Pierre Relation Between Methylmercury Exposure and Serum Paraoxonase Activity in Cree and Inuit Communities of Northern Québec |
topic_facet |
Inuit communities Cree communities Cardiovascular diseases Methylmercury PON1 activity |
description |
I7. Principal investigator: Pierre Ayotte Methylmercury (MeHg) exposure has been linked to an increased risk of cardiovascular diseases, in particular myocardial infarction. Paraoxonase 1 (PON1) is an enzyme located in the high density lipoprotein (HDL) fraction of blood lipids. It metabolizes toxic oxidized lipids associated with both low density liproprotein (LDL) and HDL. MeHg and various metals (Cd, Co, Cu, Fe, Mn, Ni, Zn) have been shown to inhibit PON1 activity in vitro but the relation between metal exposure and PON1 activity has not been studied in human populations. We hypothesize that mercury concentration in blood could be linked to decreased serum PON1 activity in populations highly exposed to methylmercury such as Aboriginal populations relying on fish for sustenance. PON1 activity will be determined in serum samples from participants to the Cree Health Survey who will be recruited in two Northern Quebec Cree communities to be visited in 2007. Associations between PON1 activity and metals will be tested, taking into consideration possible confounders. The influence of PON1 genotypes will be taken into consideration. In addition, we will examine possible relations between PON1 activity and the concentration of oxidized LDL, and the thickness of the carotid intima media. Metals in the Human Environment Strategic Network |
format |
Other/Unknown Material |
author |
Dewailley, Eric Ayotte, Pierre |
author_facet |
Dewailley, Eric Ayotte, Pierre |
author_sort |
Dewailley, Eric |
title |
Relation Between Methylmercury Exposure and Serum Paraoxonase Activity in Cree and Inuit Communities of Northern Québec |
title_short |
Relation Between Methylmercury Exposure and Serum Paraoxonase Activity in Cree and Inuit Communities of Northern Québec |
title_full |
Relation Between Methylmercury Exposure and Serum Paraoxonase Activity in Cree and Inuit Communities of Northern Québec |
title_fullStr |
Relation Between Methylmercury Exposure and Serum Paraoxonase Activity in Cree and Inuit Communities of Northern Québec |
title_full_unstemmed |
Relation Between Methylmercury Exposure and Serum Paraoxonase Activity in Cree and Inuit Communities of Northern Québec |
title_sort |
relation between methylmercury exposure and serum paraoxonase activity in cree and inuit communities of northern québec |
publishDate |
2010 |
url |
http://hdl.handle.net/10214/2163 |
genre |
inuit |
genre_facet |
inuit |
op_relation |
I;7 http://hdl.handle.net/10214/2163 |
op_rights |
All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated. |
_version_ |
1781700824056987648 |