Relation Between Methylmercury Exposure and Serum Paraoxonase Activity in Cree and Inuit Communities of Northern Québec

I7. Principal investigator: Pierre Ayotte Methylmercury (MeHg) exposure has been linked to an increased risk of cardiovascular diseases, in particular myocardial infarction. Paraoxonase 1 (PON1) is an enzyme located in the high density lipoprotein (HDL) fraction of blood lipids. It metabolizes toxic...

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Main Authors: Dewailley, Eric, Ayotte, Pierre
Format: Other/Unknown Material
Language:English
Published: 2010
Subjects:
Online Access:http://hdl.handle.net/10214/2163
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spelling ftunivguelph:oai:atrium.lib.uoguelph.ca:10214/2163 2023-11-05T03:43:03+01:00 Relation Between Methylmercury Exposure and Serum Paraoxonase Activity in Cree and Inuit Communities of Northern Québec Dewailley, Eric Ayotte, Pierre 2010-04-29T18:58:53Z application/pdf http://hdl.handle.net/10214/2163 en eng I;7 http://hdl.handle.net/10214/2163 All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated. Inuit communities Cree communities Cardiovascular diseases Methylmercury PON1 activity Other 2010 ftunivguelph 2023-10-08T06:10:31Z I7. Principal investigator: Pierre Ayotte Methylmercury (MeHg) exposure has been linked to an increased risk of cardiovascular diseases, in particular myocardial infarction. Paraoxonase 1 (PON1) is an enzyme located in the high density lipoprotein (HDL) fraction of blood lipids. It metabolizes toxic oxidized lipids associated with both low density liproprotein (LDL) and HDL. MeHg and various metals (Cd, Co, Cu, Fe, Mn, Ni, Zn) have been shown to inhibit PON1 activity in vitro but the relation between metal exposure and PON1 activity has not been studied in human populations. We hypothesize that mercury concentration in blood could be linked to decreased serum PON1 activity in populations highly exposed to methylmercury such as Aboriginal populations relying on fish for sustenance. PON1 activity will be determined in serum samples from participants to the Cree Health Survey who will be recruited in two Northern Quebec Cree communities to be visited in 2007. Associations between PON1 activity and metals will be tested, taking into consideration possible confounders. The influence of PON1 genotypes will be taken into consideration. In addition, we will examine possible relations between PON1 activity and the concentration of oxidized LDL, and the thickness of the carotid intima media. Metals in the Human Environment Strategic Network Other/Unknown Material inuit University of Guelph: DSpace digital archive
institution Open Polar
collection University of Guelph: DSpace digital archive
op_collection_id ftunivguelph
language English
topic Inuit communities
Cree communities
Cardiovascular diseases
Methylmercury
PON1 activity
spellingShingle Inuit communities
Cree communities
Cardiovascular diseases
Methylmercury
PON1 activity
Dewailley, Eric
Ayotte, Pierre
Relation Between Methylmercury Exposure and Serum Paraoxonase Activity in Cree and Inuit Communities of Northern Québec
topic_facet Inuit communities
Cree communities
Cardiovascular diseases
Methylmercury
PON1 activity
description I7. Principal investigator: Pierre Ayotte Methylmercury (MeHg) exposure has been linked to an increased risk of cardiovascular diseases, in particular myocardial infarction. Paraoxonase 1 (PON1) is an enzyme located in the high density lipoprotein (HDL) fraction of blood lipids. It metabolizes toxic oxidized lipids associated with both low density liproprotein (LDL) and HDL. MeHg and various metals (Cd, Co, Cu, Fe, Mn, Ni, Zn) have been shown to inhibit PON1 activity in vitro but the relation between metal exposure and PON1 activity has not been studied in human populations. We hypothesize that mercury concentration in blood could be linked to decreased serum PON1 activity in populations highly exposed to methylmercury such as Aboriginal populations relying on fish for sustenance. PON1 activity will be determined in serum samples from participants to the Cree Health Survey who will be recruited in two Northern Quebec Cree communities to be visited in 2007. Associations between PON1 activity and metals will be tested, taking into consideration possible confounders. The influence of PON1 genotypes will be taken into consideration. In addition, we will examine possible relations between PON1 activity and the concentration of oxidized LDL, and the thickness of the carotid intima media. Metals in the Human Environment Strategic Network
format Other/Unknown Material
author Dewailley, Eric
Ayotte, Pierre
author_facet Dewailley, Eric
Ayotte, Pierre
author_sort Dewailley, Eric
title Relation Between Methylmercury Exposure and Serum Paraoxonase Activity in Cree and Inuit Communities of Northern Québec
title_short Relation Between Methylmercury Exposure and Serum Paraoxonase Activity in Cree and Inuit Communities of Northern Québec
title_full Relation Between Methylmercury Exposure and Serum Paraoxonase Activity in Cree and Inuit Communities of Northern Québec
title_fullStr Relation Between Methylmercury Exposure and Serum Paraoxonase Activity in Cree and Inuit Communities of Northern Québec
title_full_unstemmed Relation Between Methylmercury Exposure and Serum Paraoxonase Activity in Cree and Inuit Communities of Northern Québec
title_sort relation between methylmercury exposure and serum paraoxonase activity in cree and inuit communities of northern québec
publishDate 2010
url http://hdl.handle.net/10214/2163
genre inuit
genre_facet inuit
op_relation I;7
http://hdl.handle.net/10214/2163
op_rights All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
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