The 4R genome duplication in salmonine fishes: insights from conserved non-coding elements
Gene and genome duplications are important processes in evolution. Salmonids are ideal animal model systems in which to study these processes, as they originated from a tetraploid ancestor. Conserved non-coding elements (CNEs) are of interest because of their highly conserved DNA consensus motifs sp...
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University of Guelph
2008
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ftunivguelph:oai:atrium.lib.uoguelph.ca:10214/20239 2023-11-05T03:44:48+01:00 The 4R genome duplication in salmonine fishes: insights from conserved non-coding elements Castillo, Anibal H. Ferguson, Moira M. Danzmann, Roy G. 2008 application/pdf https://hdl.handle.net/10214/20239 en eng University of Guelph https://hdl.handle.net/10214/20239 All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated. 4R Genome duplication Salmonine fisheries Conserved non-coding elements Phylogenetic Thesis 2008 ftunivguelph 2023-10-08T06:08:54Z Gene and genome duplications are important processes in evolution. Salmonids are ideal animal model systems in which to study these processes, as they originated from a tetraploid ancestor. Conserved non-coding elements (CNEs) are of interest because of their highly conserved DNA consensus motifs spanning lineages as diverse and divergent as humans and fish. The main goal of this study is to test CNEs as a tool to study genome duplications and to revisit the "4R" hypothesis and phylogeny of Salmonine fishes (Salmonidae) 'Salmo salar, Salvelinus alpinus' and ' Oncorhynchus mykiss' through the study of copy number and nucleotide variation in six pairs of CNEs. Allele numbers for most CNE sequence pairs are consistent with the 4R hypothesis, as is the symmetric phylogenetic topology shown by some CNE pairs; the estimated date of CNE duplication is consistent with the only reported range of 25-100Mya. However, the phylogenetic relationships within Salmoninae remain unresolved. Thesis Salmo salar Salvelinus alpinus University of Guelph: DSpace digital archive |
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Open Polar |
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University of Guelph: DSpace digital archive |
op_collection_id |
ftunivguelph |
language |
English |
topic |
4R Genome duplication Salmonine fisheries Conserved non-coding elements Phylogenetic |
spellingShingle |
4R Genome duplication Salmonine fisheries Conserved non-coding elements Phylogenetic Castillo, Anibal H. The 4R genome duplication in salmonine fishes: insights from conserved non-coding elements |
topic_facet |
4R Genome duplication Salmonine fisheries Conserved non-coding elements Phylogenetic |
description |
Gene and genome duplications are important processes in evolution. Salmonids are ideal animal model systems in which to study these processes, as they originated from a tetraploid ancestor. Conserved non-coding elements (CNEs) are of interest because of their highly conserved DNA consensus motifs spanning lineages as diverse and divergent as humans and fish. The main goal of this study is to test CNEs as a tool to study genome duplications and to revisit the "4R" hypothesis and phylogeny of Salmonine fishes (Salmonidae) 'Salmo salar, Salvelinus alpinus' and ' Oncorhynchus mykiss' through the study of copy number and nucleotide variation in six pairs of CNEs. Allele numbers for most CNE sequence pairs are consistent with the 4R hypothesis, as is the symmetric phylogenetic topology shown by some CNE pairs; the estimated date of CNE duplication is consistent with the only reported range of 25-100Mya. However, the phylogenetic relationships within Salmoninae remain unresolved. |
author2 |
Ferguson, Moira M. Danzmann, Roy G. |
format |
Thesis |
author |
Castillo, Anibal H. |
author_facet |
Castillo, Anibal H. |
author_sort |
Castillo, Anibal H. |
title |
The 4R genome duplication in salmonine fishes: insights from conserved non-coding elements |
title_short |
The 4R genome duplication in salmonine fishes: insights from conserved non-coding elements |
title_full |
The 4R genome duplication in salmonine fishes: insights from conserved non-coding elements |
title_fullStr |
The 4R genome duplication in salmonine fishes: insights from conserved non-coding elements |
title_full_unstemmed |
The 4R genome duplication in salmonine fishes: insights from conserved non-coding elements |
title_sort |
4r genome duplication in salmonine fishes: insights from conserved non-coding elements |
publisher |
University of Guelph |
publishDate |
2008 |
url |
https://hdl.handle.net/10214/20239 |
genre |
Salmo salar Salvelinus alpinus |
genre_facet |
Salmo salar Salvelinus alpinus |
op_relation |
https://hdl.handle.net/10214/20239 |
op_rights |
All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated. |
_version_ |
1781705634427699200 |