Maternal prepregnancy body mass index and offspring white matter microstructure: results from three birth cohorts
Prepregnancy maternal obesity is a global health problem and has been associated with offspring metabolic and mental ill-health. However, there is a knowledge gap in understanding potential neurobiological factors related to these associations. This study explored the relation between maternal prepr...
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Online Access: | http://hdl.handle.net/10481/57469 https://doi.org/10.1038/s41366-018-0268-x |
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ftunivgranada:oai:digibug.ugr.es:10481/57469 2023-05-15T17:42:41+02:00 Maternal prepregnancy body mass index and offspring white matter microstructure: results from three birth cohorts Verdejo Román, Juan Torres Espinola, Francisco Jose Campos, Daniel Campoy Folgoso, Cristina 2019 http://hdl.handle.net/10481/57469 https://doi.org/10.1038/s41366-018-0268-x eng eng Springer Nature info:eu-repo/grantAgreement/EC/FP7/633595 DynaHEALTH info:eu-repo/grantAgreement/EC/FP7/733206 LifeCycle Verdejo-Román, J., Björnholm, L., Muetzel, R.L. et al. Maternal prepregnancy body mass index and offspring white matter microstructure: results from three birth cohorts. Int J Obes 43, 1995–2006 (2019). [https://doi.org/10.1038/s41366-018-0268-x] http://hdl.handle.net/10481/57469 doi:10.1038/s41366-018-0268-x Atribución-NoComercial-SinDerivadas 3.0 España http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess CC-BY-NC-ND info:eu-repo/semantics/article 2019 ftunivgranada https://doi.org/10.1038/s41366-018-0268-x 2021-07-20T23:21:12Z Prepregnancy maternal obesity is a global health problem and has been associated with offspring metabolic and mental ill-health. However, there is a knowledge gap in understanding potential neurobiological factors related to these associations. This study explored the relation between maternal prepregnancy body mass index (BMI) and offspring brain white matter microstructure at the age of 6, 10, and 26 years in three independent cohorts. Maternal BMI was associated with higher FA and lower MD in multiple brain tracts in offspring aged 10 and 26 years, but not at 6 years of age. Future studies should examine whether our observations can be replicated and explore the potential causal nature of the findings. This work was supported by the European Union’s Horizon 2020 research and innovation program [grant agreement no. 633595 DynaHEALTH] and no. 733206 LifeCycle], the Netherlands Organization for Health Research and Development [ZONMW Vici project 016.VICI.170.200]. The PREOBE cohort was funded by Spanish Ministry of Innovation and Science. Junta de Andalucía: Excellence Projects (P06-CTS-02341) and Spanish Ministry of Economy and Competitiveness (BFU2012-40254-C03-01). The first phase of the Generation R Study is made possible by financial support from the Erasmus Medical Centre, the Erasmus University, and the Netherlands Organization for Health Research and Development (ZonMW, grant ZonMW Geestkracht 10.000.1003). The Northern Finland Birth Cohort 1986 is funded by University of Oulu, University Hospital of Oulu, Academy of Finland (EGEA), Sigrid Juselius Foundation, European Commission (EURO-BLCS, Framework 5 award QLG1-CT-2000-01643), NIH/NIMH (5R01MH63706:02) Article in Journal/Newspaper Northern Finland DIGIBUG: Repositorio Institucional de la Universidad de Granada Sigrid ENVELOPE(-64.233,-64.233,-64.250,-64.250) International Journal of Obesity 43 10 1995 2006 |
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DIGIBUG: Repositorio Institucional de la Universidad de Granada |
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English |
description |
Prepregnancy maternal obesity is a global health problem and has been associated with offspring metabolic and mental ill-health. However, there is a knowledge gap in understanding potential neurobiological factors related to these associations. This study explored the relation between maternal prepregnancy body mass index (BMI) and offspring brain white matter microstructure at the age of 6, 10, and 26 years in three independent cohorts. Maternal BMI was associated with higher FA and lower MD in multiple brain tracts in offspring aged 10 and 26 years, but not at 6 years of age. Future studies should examine whether our observations can be replicated and explore the potential causal nature of the findings. This work was supported by the European Union’s Horizon 2020 research and innovation program [grant agreement no. 633595 DynaHEALTH] and no. 733206 LifeCycle], the Netherlands Organization for Health Research and Development [ZONMW Vici project 016.VICI.170.200]. The PREOBE cohort was funded by Spanish Ministry of Innovation and Science. Junta de Andalucía: Excellence Projects (P06-CTS-02341) and Spanish Ministry of Economy and Competitiveness (BFU2012-40254-C03-01). The first phase of the Generation R Study is made possible by financial support from the Erasmus Medical Centre, the Erasmus University, and the Netherlands Organization for Health Research and Development (ZonMW, grant ZonMW Geestkracht 10.000.1003). The Northern Finland Birth Cohort 1986 is funded by University of Oulu, University Hospital of Oulu, Academy of Finland (EGEA), Sigrid Juselius Foundation, European Commission (EURO-BLCS, Framework 5 award QLG1-CT-2000-01643), NIH/NIMH (5R01MH63706:02) |
format |
Article in Journal/Newspaper |
author |
Verdejo Román, Juan Torres Espinola, Francisco Jose Campos, Daniel Campoy Folgoso, Cristina |
spellingShingle |
Verdejo Román, Juan Torres Espinola, Francisco Jose Campos, Daniel Campoy Folgoso, Cristina Maternal prepregnancy body mass index and offspring white matter microstructure: results from three birth cohorts |
author_facet |
Verdejo Román, Juan Torres Espinola, Francisco Jose Campos, Daniel Campoy Folgoso, Cristina |
author_sort |
Verdejo Román, Juan |
title |
Maternal prepregnancy body mass index and offspring white matter microstructure: results from three birth cohorts |
title_short |
Maternal prepregnancy body mass index and offspring white matter microstructure: results from three birth cohorts |
title_full |
Maternal prepregnancy body mass index and offspring white matter microstructure: results from three birth cohorts |
title_fullStr |
Maternal prepregnancy body mass index and offspring white matter microstructure: results from three birth cohorts |
title_full_unstemmed |
Maternal prepregnancy body mass index and offspring white matter microstructure: results from three birth cohorts |
title_sort |
maternal prepregnancy body mass index and offspring white matter microstructure: results from three birth cohorts |
publisher |
Springer Nature |
publishDate |
2019 |
url |
http://hdl.handle.net/10481/57469 https://doi.org/10.1038/s41366-018-0268-x |
long_lat |
ENVELOPE(-64.233,-64.233,-64.250,-64.250) |
geographic |
Sigrid |
geographic_facet |
Sigrid |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
info:eu-repo/grantAgreement/EC/FP7/633595 DynaHEALTH info:eu-repo/grantAgreement/EC/FP7/733206 LifeCycle Verdejo-Román, J., Björnholm, L., Muetzel, R.L. et al. Maternal prepregnancy body mass index and offspring white matter microstructure: results from three birth cohorts. Int J Obes 43, 1995–2006 (2019). [https://doi.org/10.1038/s41366-018-0268-x] http://hdl.handle.net/10481/57469 doi:10.1038/s41366-018-0268-x |
op_rights |
Atribución-NoComercial-SinDerivadas 3.0 España http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1038/s41366-018-0268-x |
container_title |
International Journal of Obesity |
container_volume |
43 |
container_issue |
10 |
container_start_page |
1995 |
op_container_end_page |
2006 |
_version_ |
1766144595598508032 |