Axial spondyloarthritis - with special emphasis on prevalence, perceived health and predictors

The objectives of this thesis were to assess the validity of the diagnostic codes for ankylosing spondylitis and undifferentiated spondyloarthritis in the national patient register (study I), and to estimate the prevalence of ankylosing spondylitis in Sweden, as well as to compare the prevalence acc...

Full description

Bibliographic Details
Published in:Arthritis Research & Therapy
Main Author: Lindström, Ulf
Format: Doctoral or Postdoctoral Thesis
Language:English
Published: 2016
Subjects:
axial spondyloarthritis
ankylosing spondylitis
epidemiology
Northern Sweden
Online Access:http://hdl.handle.net/2077/47405
id ftunivgoeteborg:oai:gupea.ub.gu.se:2077/47405
record_format openpolar
spelling ftunivgoeteborg:oai:gupea.ub.gu.se:2077/47405 2023-10-29T02:38:58+01:00 Axial spondyloarthritis - with special emphasis on prevalence, perceived health and predictors Lindström, Ulf 2016-11-18 application/pdf http://hdl.handle.net/2077/47405 eng eng I. Lindström U, Exarchou S, Sigurdardottir V, Sundström B, Askling J, Eriksson J K, Forsblad-d'Elia H, Turesson C, Kristensen L E, Jacobsson L T H. Validity of ankylosing spondylitis and undifferentiated spondyloarthritis diagnoses in the Swedish National Patient Register. Scandinavian Journal of Rheumatology, 2015;44:369. ::doi::10.3109/03009742.2015.1010572 II. Exarchou S, Lindström U, Askling J, Eriksson J K, Forsblad-d'Elia H, Neovius M, Turesson C, Kristensen L E, Jacobsson L T H. The prevalence of clinically diagnosed ankylosing spondylitis and its clinical anifestations: a nationwide register study. Arthritis Research and Therapy, 2015;17:118. ::doi::10.1186/s13075-015-0627-0 III. Lindström U, Bremander A, Haglund E, Bergman S, Petersson I F, Jacobsson L T H. Back pain and health status in patients with clinically diagnosed ankylosing spondylitis, psoriatic arthritis and other spondyloarthritis: a cross-sectional population-based study. BMC Musculoskeletal Disorders, 2016;17:106. ::doi::10.1186/s12891-016-0960-8 IV. Lindström U, Forsblad-d'Elia H, Askling J, Kristensen L E, Lie E, Exarchou S, Jacobsson L T H. Perinatal characteristics, older siblings, and risk of ankylosing spondylitis: a case-control study based on national registers. Arthritis Research and Therapy, 2016;18:16. ::doi:10.1186/s13075-016-0917-1 V. Lindström U, Exarchou S, Lie E, Dehlin M, Forsblad-d'Elia H, Askling J, Jacobsson L T H. Childhood hospitalisation with infections and later development of ankylosing spondylitis: a national case-control study. Arthritis Research and Therapy, 2016;18:240. ::doi::10.1186/s13075-016-1141-8 978-91-628-9940-0 (pdf) 978-91-628-9939-4 (print) http://hdl.handle.net/2077/47405 axial spondyloarthritis ankylosing spondylitis epidemiology text Doctoral thesis Doctor of Philosophy (Medicine) 2016 ftunivgoeteborg https://doi.org/10.1186/s13075-016-0917-1 2023-10-04T21:16:00Z The objectives of this thesis were to assess the validity of the diagnostic codes for ankylosing spondylitis and undifferentiated spondyloarthritis in the national patient register (study I), and to estimate the prevalence of ankylosing spondylitis in Sweden, as well as to compare the prevalence according to geographic and demographic factors (study II). Further, to compare inflammatory back pain, and perceived health, in different subtypes of spondyloarthritis (study III), and to investigate predictive associations between perinatal characteristics, and childhood infections, with later development of ankylosing spondylitis (study IV and V). The diagnoses in the register, were found to have a high validity. The point-prevalence of ankylosing spondylitis in Sweden, in 2009, was estimated to be 0.18%, with a higher prevalence associated with a shorter formal education, and a higher prevalence in northern Sweden compared to the southern parts. Current inflammatory back pain was common across the three subtypes of spondyloarthritis analyzed (43% of ankylosing spondylitis, 31% of psoriatic arthritis and 39% of other spondyloarthritis) and the groups reported similar levels of perceived health. Having older siblings (odds ratio[OR]: 1.23; 95% confidence interval[CI]: 1.09-1.39), and hospitalization with respiratory tract infections during childhood (OR: 1.24; 95% CI: 1.07-1.44), were associated with an increased risk for development of ankylosing spondylitis, and appendicitis with a decreased risk (OR: 0.59; 95% CI: 0.41-0.83). In conclusion, axial spondyloarthritis is a significant health issue, and early life exposures appear to be associated with the disease development. Doctoral or Postdoctoral Thesis Northern Sweden University of Gothenburg: GUPEA (Gothenburg University Publications Electronic Archive) Arthritis Research & Therapy 18 1
institution Open Polar
collection University of Gothenburg: GUPEA (Gothenburg University Publications Electronic Archive)
op_collection_id ftunivgoeteborg
language English
topic axial spondyloarthritis
ankylosing spondylitis
epidemiology
spellingShingle axial spondyloarthritis
ankylosing spondylitis
epidemiology
Lindström, Ulf
Axial spondyloarthritis - with special emphasis on prevalence, perceived health and predictors
topic_facet axial spondyloarthritis
ankylosing spondylitis
epidemiology
description The objectives of this thesis were to assess the validity of the diagnostic codes for ankylosing spondylitis and undifferentiated spondyloarthritis in the national patient register (study I), and to estimate the prevalence of ankylosing spondylitis in Sweden, as well as to compare the prevalence according to geographic and demographic factors (study II). Further, to compare inflammatory back pain, and perceived health, in different subtypes of spondyloarthritis (study III), and to investigate predictive associations between perinatal characteristics, and childhood infections, with later development of ankylosing spondylitis (study IV and V). The diagnoses in the register, were found to have a high validity. The point-prevalence of ankylosing spondylitis in Sweden, in 2009, was estimated to be 0.18%, with a higher prevalence associated with a shorter formal education, and a higher prevalence in northern Sweden compared to the southern parts. Current inflammatory back pain was common across the three subtypes of spondyloarthritis analyzed (43% of ankylosing spondylitis, 31% of psoriatic arthritis and 39% of other spondyloarthritis) and the groups reported similar levels of perceived health. Having older siblings (odds ratio[OR]: 1.23; 95% confidence interval[CI]: 1.09-1.39), and hospitalization with respiratory tract infections during childhood (OR: 1.24; 95% CI: 1.07-1.44), were associated with an increased risk for development of ankylosing spondylitis, and appendicitis with a decreased risk (OR: 0.59; 95% CI: 0.41-0.83). In conclusion, axial spondyloarthritis is a significant health issue, and early life exposures appear to be associated with the disease development.
format Doctoral or Postdoctoral Thesis
author Lindström, Ulf
author_facet Lindström, Ulf
author_sort Lindström, Ulf
title Axial spondyloarthritis - with special emphasis on prevalence, perceived health and predictors
title_short Axial spondyloarthritis - with special emphasis on prevalence, perceived health and predictors
title_full Axial spondyloarthritis - with special emphasis on prevalence, perceived health and predictors
title_fullStr Axial spondyloarthritis - with special emphasis on prevalence, perceived health and predictors
title_full_unstemmed Axial spondyloarthritis - with special emphasis on prevalence, perceived health and predictors
title_sort axial spondyloarthritis - with special emphasis on prevalence, perceived health and predictors
publishDate 2016
url http://hdl.handle.net/2077/47405
genre Northern Sweden
genre_facet Northern Sweden
op_relation I. Lindström U, Exarchou S, Sigurdardottir V, Sundström B, Askling J, Eriksson J K, Forsblad-d'Elia H, Turesson C, Kristensen L E, Jacobsson L T H. Validity of ankylosing spondylitis and undifferentiated spondyloarthritis diagnoses in the Swedish National Patient Register. Scandinavian Journal of Rheumatology, 2015;44:369. ::doi::10.3109/03009742.2015.1010572
II. Exarchou S, Lindström U, Askling J, Eriksson J K, Forsblad-d'Elia H, Neovius M, Turesson C, Kristensen L E, Jacobsson L T H. The prevalence of clinically diagnosed ankylosing spondylitis and its clinical anifestations: a nationwide register study. Arthritis Research and Therapy, 2015;17:118. ::doi::10.1186/s13075-015-0627-0
III. Lindström U, Bremander A, Haglund E, Bergman S, Petersson I F, Jacobsson L T H. Back pain and health status in patients with clinically diagnosed ankylosing spondylitis, psoriatic arthritis and other spondyloarthritis: a cross-sectional population-based study. BMC Musculoskeletal Disorders, 2016;17:106. ::doi::10.1186/s12891-016-0960-8
IV. Lindström U, Forsblad-d'Elia H, Askling J, Kristensen L E, Lie E, Exarchou S, Jacobsson L T H. Perinatal characteristics, older siblings, and risk of ankylosing spondylitis: a case-control study based on national registers. Arthritis Research and Therapy, 2016;18:16. ::doi:10.1186/s13075-016-0917-1
V. Lindström U, Exarchou S, Lie E, Dehlin M, Forsblad-d'Elia H, Askling J, Jacobsson L T H. Childhood hospitalisation with infections and later development of ankylosing spondylitis: a national case-control study. Arthritis Research and Therapy, 2016;18:240. ::doi::10.1186/s13075-016-1141-8
978-91-628-9940-0 (pdf)
978-91-628-9939-4 (print)
http://hdl.handle.net/2077/47405
op_doi https://doi.org/10.1186/s13075-016-0917-1
container_title Arthritis Research & Therapy
container_volume 18
container_issue 1
_version_ 1781065478262751232

Similar Items