Fine Mapping and Evolution of the Major Sex Determining Region in Turbot (Scophthalmus maximus)
Fish sex determination (SD) systems are varied, suggesting evolutionary changes including either multiple evolution origins of genetic SD from nongenetic systems (such as environmental SD) and/or turnover events replacing one genetic system by another. When genetic SD is found, cytological different...
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ftunivgironadugi:oai:dugi-doc.udg.edu:10256/16511 2023-05-15T18:15:45+02:00 Fine Mapping and Evolution of the Major Sex Determining Region in Turbot (Scophthalmus maximus) Taboada, Xoana Hermida, Miguel Pardo, Belén G. Vera Rodríguez, Manuel Piferrer, Francesc Viñas, Ana Bouza da Costa, Carmen Martínez, Paulino 2014-10-01 application/pdf http://hdl.handle.net/10256/16511 eng eng Genetics Society of America info:eu-repo/semantics/altIdentifier/doi/10.1534/g3.114.012328 info:eu-repo/semantics/altIdentifier/eissn/2160-1836 http://hdl.handle.net/10256/16511 Attribution 3.0 International http://creativecommons.org/licenses/by/3.0/ info:eu-repo/semantics/openAccess CC-BY G3: Genes Genomes Genetics, 2014, vol. 4, núm. 10, p. 1871-1880 Articles publicats (D-B) Rèmols de petxines Turbots Peixos -- Citogenètica Fishes -- Cytogenetics Peixos -- Conducta sexual Fishes -- Sexual behavior info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer-reviewed 2014 ftunivgironadugi https://doi.org/10.1534/g3.114.012328 2022-05-19T06:14:29Z Fish sex determination (SD) systems are varied, suggesting evolutionary changes including either multiple evolution origins of genetic SD from nongenetic systems (such as environmental SD) and/or turnover events replacing one genetic system by another. When genetic SD is found, cytological differentiation between the two members of the sex chromosome pair is often minor or undetectable. The turbot (Scophthalmus maximus), a valuable commercial flatfish, has a ZZ/ZW system and a major SD region on linkage group 5 (LG5), but there are also other minor genetic and environmental influences. We here report refined mapping of the turbot SD region, supported by comparative mapping with model fish species, to identify the turbot master SD gene. Six genes were located to the SD region, two of them associated with gonad development (sox2 and dnajc19). All showed a high association with sex within families (P = 0), but not at the population level, so they are probably partially sex-linked genes, but not SD gene itself. Analysis of crossovers in LG5 using two families confirmed a ZZ/ZW system in turbot and suggested a revised map position for the master gene. Genetic diversity and differentiation for 25 LG5 genetic markers showed no differences between males and females sampled from a wild population, suggesting a recent origin of the SD region in turbot. We also analyzed associations with markers of the most relevant sex-related linkage groups in brill (S. rhombus), a closely related species to turbot; the data suggest that an ancient XX/XY system in brill changed to a ZZ/ZW mechanism in turbot Article in Journal/Newspaper Scophthalmus maximus Turbot Universitat de Girona: DUGiDocs (UdG Digital Repository) G3 Genes|Genomes|Genetics 4 10 1871 1880 |
institution |
Open Polar |
collection |
Universitat de Girona: DUGiDocs (UdG Digital Repository) |
op_collection_id |
ftunivgironadugi |
language |
English |
topic |
Rèmols de petxines Turbots Peixos -- Citogenètica Fishes -- Cytogenetics Peixos -- Conducta sexual Fishes -- Sexual behavior |
spellingShingle |
Rèmols de petxines Turbots Peixos -- Citogenètica Fishes -- Cytogenetics Peixos -- Conducta sexual Fishes -- Sexual behavior Taboada, Xoana Hermida, Miguel Pardo, Belén G. Vera Rodríguez, Manuel Piferrer, Francesc Viñas, Ana Bouza da Costa, Carmen Martínez, Paulino Fine Mapping and Evolution of the Major Sex Determining Region in Turbot (Scophthalmus maximus) |
topic_facet |
Rèmols de petxines Turbots Peixos -- Citogenètica Fishes -- Cytogenetics Peixos -- Conducta sexual Fishes -- Sexual behavior |
description |
Fish sex determination (SD) systems are varied, suggesting evolutionary changes including either multiple evolution origins of genetic SD from nongenetic systems (such as environmental SD) and/or turnover events replacing one genetic system by another. When genetic SD is found, cytological differentiation between the two members of the sex chromosome pair is often minor or undetectable. The turbot (Scophthalmus maximus), a valuable commercial flatfish, has a ZZ/ZW system and a major SD region on linkage group 5 (LG5), but there are also other minor genetic and environmental influences. We here report refined mapping of the turbot SD region, supported by comparative mapping with model fish species, to identify the turbot master SD gene. Six genes were located to the SD region, two of them associated with gonad development (sox2 and dnajc19). All showed a high association with sex within families (P = 0), but not at the population level, so they are probably partially sex-linked genes, but not SD gene itself. Analysis of crossovers in LG5 using two families confirmed a ZZ/ZW system in turbot and suggested a revised map position for the master gene. Genetic diversity and differentiation for 25 LG5 genetic markers showed no differences between males and females sampled from a wild population, suggesting a recent origin of the SD region in turbot. We also analyzed associations with markers of the most relevant sex-related linkage groups in brill (S. rhombus), a closely related species to turbot; the data suggest that an ancient XX/XY system in brill changed to a ZZ/ZW mechanism in turbot |
format |
Article in Journal/Newspaper |
author |
Taboada, Xoana Hermida, Miguel Pardo, Belén G. Vera Rodríguez, Manuel Piferrer, Francesc Viñas, Ana Bouza da Costa, Carmen Martínez, Paulino |
author_facet |
Taboada, Xoana Hermida, Miguel Pardo, Belén G. Vera Rodríguez, Manuel Piferrer, Francesc Viñas, Ana Bouza da Costa, Carmen Martínez, Paulino |
author_sort |
Taboada, Xoana |
title |
Fine Mapping and Evolution of the Major Sex Determining Region in Turbot (Scophthalmus maximus) |
title_short |
Fine Mapping and Evolution of the Major Sex Determining Region in Turbot (Scophthalmus maximus) |
title_full |
Fine Mapping and Evolution of the Major Sex Determining Region in Turbot (Scophthalmus maximus) |
title_fullStr |
Fine Mapping and Evolution of the Major Sex Determining Region in Turbot (Scophthalmus maximus) |
title_full_unstemmed |
Fine Mapping and Evolution of the Major Sex Determining Region in Turbot (Scophthalmus maximus) |
title_sort |
fine mapping and evolution of the major sex determining region in turbot (scophthalmus maximus) |
publisher |
Genetics Society of America |
publishDate |
2014 |
url |
http://hdl.handle.net/10256/16511 |
genre |
Scophthalmus maximus Turbot |
genre_facet |
Scophthalmus maximus Turbot |
op_source |
G3: Genes Genomes Genetics, 2014, vol. 4, núm. 10, p. 1871-1880 Articles publicats (D-B) |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1534/g3.114.012328 info:eu-repo/semantics/altIdentifier/eissn/2160-1836 http://hdl.handle.net/10256/16511 |
op_rights |
Attribution 3.0 International http://creativecommons.org/licenses/by/3.0/ info:eu-repo/semantics/openAccess |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1534/g3.114.012328 |
container_title |
G3 Genes|Genomes|Genetics |
container_volume |
4 |
container_issue |
10 |
container_start_page |
1871 |
op_container_end_page |
1880 |
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1766188949441609728 |