Buried alive : how osteoblasts become osteocytes
During osteogenesis, osteoblasts lay down osteoid and transform into osteocytes embedded in mineralized bone matrix. Despite the fact that osteocytes are the most abundant cellular component of bone, little is known about the process of osteoblast-to-osteocyte transformation. What is known is that o...
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ftunivgent:oai:archive.ugent.be:8646034 2023-06-11T04:16:21+02:00 Buried alive : how osteoblasts become osteocytes Franz-Odendaal, Tamara A. Hall, Brian K. Witten, Paul Eckhard 2006 application/pdf https://biblio.ugent.be/publication/8646034 http://hdl.handle.net/1854/LU-8646034 https://doi.org/10.1002/dvdy.20603 https://biblio.ugent.be/publication/8646034/file/8646035 eng eng https://biblio.ugent.be/publication/8646034 http://hdl.handle.net/1854/LU-8646034 http://dx.doi.org/10.1002/dvdy.20603 https://biblio.ugent.be/publication/8646034/file/8646035 No license (in copyright) info:eu-repo/semantics/restrictedAccess DEVELOPMENTAL DYNAMICS ISSN: 1058-8388 ISSN: 1097-0177 Biology and Life Sciences Developmental Biology osteoblast osteocyte osteogenesis intramembranous ossification preosteoblast osteoid-osteocyte preosteocyte TRABECULAR BONE PACKETS MEAN WALL THICKNESS ORYZIAS-LATIPES TELEOSTEI SALMON SALMO-SALAR GROWTH-FACTOR-I RAT BONE MESSENGER-RNA HYPERTROPHIC CHONDROCYTES SKELETAL DEVELOPMENT CELL-PROLIFERATION journalArticle info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2006 ftunivgent https://doi.org/10.1002/dvdy.20603 2023-05-10T22:38:25Z During osteogenesis, osteoblasts lay down osteoid and transform into osteocytes embedded in mineralized bone matrix. Despite the fact that osteocytes are the most abundant cellular component of bone, little is known about the process of osteoblast-to-osteocyte transformation. What is known is that osteoblasts undergo a number of changes during this transformation, yet retain their connections to preosteoblasts and osteocytes. This review explores the osteoblast-to-osteocyte transformation during intramembranous ossification from both morphological and molecular perspectives. We investigate how these data support five schemes that describe how an osteoblast could become entrapped in the bone matrix (in mammals) and suggest one of the five scenarios that best fits as a model. Those osteoblasts on the bone surface that are destined for burial and destined to become osteocytes slow down matrix production compared to neighbouring osteoblasts, which continue to produce bone matrix. That is, cells that continue to produce matrix actively bury cells producing less or no new bone matrix (passive burial). We summarize which morphological and molecular changes could be used as characters (or markers) to follow the transformation process. Article in Journal/Newspaper Salmo salar Ghent University Academic Bibliography Developmental Dynamics 235 1 176 190 |
institution |
Open Polar |
collection |
Ghent University Academic Bibliography |
op_collection_id |
ftunivgent |
language |
English |
topic |
Biology and Life Sciences Developmental Biology osteoblast osteocyte osteogenesis intramembranous ossification preosteoblast osteoid-osteocyte preosteocyte TRABECULAR BONE PACKETS MEAN WALL THICKNESS ORYZIAS-LATIPES TELEOSTEI SALMON SALMO-SALAR GROWTH-FACTOR-I RAT BONE MESSENGER-RNA HYPERTROPHIC CHONDROCYTES SKELETAL DEVELOPMENT CELL-PROLIFERATION |
spellingShingle |
Biology and Life Sciences Developmental Biology osteoblast osteocyte osteogenesis intramembranous ossification preosteoblast osteoid-osteocyte preosteocyte TRABECULAR BONE PACKETS MEAN WALL THICKNESS ORYZIAS-LATIPES TELEOSTEI SALMON SALMO-SALAR GROWTH-FACTOR-I RAT BONE MESSENGER-RNA HYPERTROPHIC CHONDROCYTES SKELETAL DEVELOPMENT CELL-PROLIFERATION Franz-Odendaal, Tamara A. Hall, Brian K. Witten, Paul Eckhard Buried alive : how osteoblasts become osteocytes |
topic_facet |
Biology and Life Sciences Developmental Biology osteoblast osteocyte osteogenesis intramembranous ossification preosteoblast osteoid-osteocyte preosteocyte TRABECULAR BONE PACKETS MEAN WALL THICKNESS ORYZIAS-LATIPES TELEOSTEI SALMON SALMO-SALAR GROWTH-FACTOR-I RAT BONE MESSENGER-RNA HYPERTROPHIC CHONDROCYTES SKELETAL DEVELOPMENT CELL-PROLIFERATION |
description |
During osteogenesis, osteoblasts lay down osteoid and transform into osteocytes embedded in mineralized bone matrix. Despite the fact that osteocytes are the most abundant cellular component of bone, little is known about the process of osteoblast-to-osteocyte transformation. What is known is that osteoblasts undergo a number of changes during this transformation, yet retain their connections to preosteoblasts and osteocytes. This review explores the osteoblast-to-osteocyte transformation during intramembranous ossification from both morphological and molecular perspectives. We investigate how these data support five schemes that describe how an osteoblast could become entrapped in the bone matrix (in mammals) and suggest one of the five scenarios that best fits as a model. Those osteoblasts on the bone surface that are destined for burial and destined to become osteocytes slow down matrix production compared to neighbouring osteoblasts, which continue to produce bone matrix. That is, cells that continue to produce matrix actively bury cells producing less or no new bone matrix (passive burial). We summarize which morphological and molecular changes could be used as characters (or markers) to follow the transformation process. |
format |
Article in Journal/Newspaper |
author |
Franz-Odendaal, Tamara A. Hall, Brian K. Witten, Paul Eckhard |
author_facet |
Franz-Odendaal, Tamara A. Hall, Brian K. Witten, Paul Eckhard |
author_sort |
Franz-Odendaal, Tamara A. |
title |
Buried alive : how osteoblasts become osteocytes |
title_short |
Buried alive : how osteoblasts become osteocytes |
title_full |
Buried alive : how osteoblasts become osteocytes |
title_fullStr |
Buried alive : how osteoblasts become osteocytes |
title_full_unstemmed |
Buried alive : how osteoblasts become osteocytes |
title_sort |
buried alive : how osteoblasts become osteocytes |
publishDate |
2006 |
url |
https://biblio.ugent.be/publication/8646034 http://hdl.handle.net/1854/LU-8646034 https://doi.org/10.1002/dvdy.20603 https://biblio.ugent.be/publication/8646034/file/8646035 |
genre |
Salmo salar |
genre_facet |
Salmo salar |
op_source |
DEVELOPMENTAL DYNAMICS ISSN: 1058-8388 ISSN: 1097-0177 |
op_relation |
https://biblio.ugent.be/publication/8646034 http://hdl.handle.net/1854/LU-8646034 http://dx.doi.org/10.1002/dvdy.20603 https://biblio.ugent.be/publication/8646034/file/8646035 |
op_rights |
No license (in copyright) info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1002/dvdy.20603 |
container_title |
Developmental Dynamics |
container_volume |
235 |
container_issue |
1 |
container_start_page |
176 |
op_container_end_page |
190 |
_version_ |
1768374048784384000 |