Modulations of neuroendocrine stress responses during confinement in Antarctica and the role of hypobaric hypoxia
The Antarctic continent is an environment of extreme conditions. Only few research stations exist that are occupied throughout the year. The German station Neumayer III and the French-Italian Concordia station are such research platforms and human outposts. The seasonal shifts of complete daylight (...
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ftunivgent:oai:archive.ugent.be:8600321 2023-06-11T04:05:39+02:00 Modulations of neuroendocrine stress responses during confinement in Antarctica and the role of hypobaric hypoxia Strewe, Claudia Thieme, Detlef Dangoisse, Carole Fiedel, Barbara van den Berg, Floris Bauer, Holger Salam, Alex P Gössmann-Lang, Petra Campolongo, Patrizia Moser, Dominique Quintens, Roel Moreels, Marjan Baatout, Sarah Kohlberg, Eberhard Schelling, Gustav Choukèr, Alexander Feuerecker, Matthias 2018 application/pdf https://biblio.ugent.be/publication/8600321 http://hdl.handle.net/1854/LU-8600321 https://doi.org/10.3389/fphys.2018.01647 https://biblio.ugent.be/publication/8600321/file/8600322 eng eng https://biblio.ugent.be/publication/8600321 http://hdl.handle.net/1854/LU-8600321 http://dx.doi.org/10.3389/fphys.2018.01647 https://biblio.ugent.be/publication/8600321/file/8600322 No license (in copyright) info:eu-repo/semantics/openAccess FRONTIERS IN PHYSIOLOGY ISSN: 1664-042X Medicine and Health Sciences Biology and Life Sciences Earth and Environmental Sciences endocannabinoids catecholamines glucocorticoids hypobaric hypoxia high altitude Antarctica SYMPATHETIC-NERVOUS-SYSTEM HIGH-ALTITUDE PHYSIOLOGICAL-RESPONSES ENDOCANNABINOID SYSTEM NORMOBARIC HYPOXIA GENE-EXPRESSION BLOOD-PRESSURE ADAPTATION RELEASE ANANDAMIDE journalArticle info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2018 ftunivgent https://doi.org/10.3389/fphys.2018.01647 2023-05-10T22:42:55Z The Antarctic continent is an environment of extreme conditions. Only few research stations exist that are occupied throughout the year. The German station Neumayer III and the French-Italian Concordia station are such research platforms and human outposts. The seasonal shifts of complete daylight (summer) to complete darkness (winter) as well as massive changes in outside temperatures (down to -80°C at Concordia) during winter result in complete confinement of the crews from the outside world. In addition, the crew at Concordia is subjected to hypobaric hypoxia of ∼650 hPa as the station is situated at high altitude (3,233 m). We studied three expedition crews at Neumayer III (sea level) (n = 16) and two at Concordia (high altitude) (n = 15) to determine the effects of hypobaric hypoxia on hormonal/metabolic stress parameters [endocannabinoids (ECs), catecholamines, and glucocorticoids] and evaluated the psychological stress over a period of 11 months including winter confinement. In the Neumayer III (sea level) crew, EC and n-acylethanolamide (NAE) concentrations increased significantly already at the beginning of the deployment (p < 0.001) whereas catecholamines and cortisol remained unaffected. Over the year, ECs and NAEs stayed elevated and fluctuated before slowly decreasing till the end of the deployment. The classical stress hormones showed small increases in the last third of deployment. By contrast, at Concordia (high altitude), norepinephrine concentrations increased significantly at the beginning (p < 0.001) which was paralleled by low EC levels. Prior to the second half of deployment, norepinephrine declined constantly to end on a low plateau level, whereas then the EC concentrations increased significantly in this second period during the overwintering (p < 0.001). Psychometric data showed no significant changes in the crews at either station. These findings demonstrate that exposition of healthy humans to the physically challenging extreme environment of Antarctica (i) has a distinct ... Article in Journal/Newspaper Antarc* Antarctic Antarctica Ghent University Academic Bibliography Antarctic Concordia Station ENVELOPE(123.333,123.333,-75.100,-75.100) Neumayer The Antarctic Frontiers in Physiology 9 |
institution |
Open Polar |
collection |
Ghent University Academic Bibliography |
op_collection_id |
ftunivgent |
language |
English |
topic |
Medicine and Health Sciences Biology and Life Sciences Earth and Environmental Sciences endocannabinoids catecholamines glucocorticoids hypobaric hypoxia high altitude Antarctica SYMPATHETIC-NERVOUS-SYSTEM HIGH-ALTITUDE PHYSIOLOGICAL-RESPONSES ENDOCANNABINOID SYSTEM NORMOBARIC HYPOXIA GENE-EXPRESSION BLOOD-PRESSURE ADAPTATION RELEASE ANANDAMIDE |
spellingShingle |
Medicine and Health Sciences Biology and Life Sciences Earth and Environmental Sciences endocannabinoids catecholamines glucocorticoids hypobaric hypoxia high altitude Antarctica SYMPATHETIC-NERVOUS-SYSTEM HIGH-ALTITUDE PHYSIOLOGICAL-RESPONSES ENDOCANNABINOID SYSTEM NORMOBARIC HYPOXIA GENE-EXPRESSION BLOOD-PRESSURE ADAPTATION RELEASE ANANDAMIDE Strewe, Claudia Thieme, Detlef Dangoisse, Carole Fiedel, Barbara van den Berg, Floris Bauer, Holger Salam, Alex P Gössmann-Lang, Petra Campolongo, Patrizia Moser, Dominique Quintens, Roel Moreels, Marjan Baatout, Sarah Kohlberg, Eberhard Schelling, Gustav Choukèr, Alexander Feuerecker, Matthias Modulations of neuroendocrine stress responses during confinement in Antarctica and the role of hypobaric hypoxia |
topic_facet |
Medicine and Health Sciences Biology and Life Sciences Earth and Environmental Sciences endocannabinoids catecholamines glucocorticoids hypobaric hypoxia high altitude Antarctica SYMPATHETIC-NERVOUS-SYSTEM HIGH-ALTITUDE PHYSIOLOGICAL-RESPONSES ENDOCANNABINOID SYSTEM NORMOBARIC HYPOXIA GENE-EXPRESSION BLOOD-PRESSURE ADAPTATION RELEASE ANANDAMIDE |
description |
The Antarctic continent is an environment of extreme conditions. Only few research stations exist that are occupied throughout the year. The German station Neumayer III and the French-Italian Concordia station are such research platforms and human outposts. The seasonal shifts of complete daylight (summer) to complete darkness (winter) as well as massive changes in outside temperatures (down to -80°C at Concordia) during winter result in complete confinement of the crews from the outside world. In addition, the crew at Concordia is subjected to hypobaric hypoxia of ∼650 hPa as the station is situated at high altitude (3,233 m). We studied three expedition crews at Neumayer III (sea level) (n = 16) and two at Concordia (high altitude) (n = 15) to determine the effects of hypobaric hypoxia on hormonal/metabolic stress parameters [endocannabinoids (ECs), catecholamines, and glucocorticoids] and evaluated the psychological stress over a period of 11 months including winter confinement. In the Neumayer III (sea level) crew, EC and n-acylethanolamide (NAE) concentrations increased significantly already at the beginning of the deployment (p < 0.001) whereas catecholamines and cortisol remained unaffected. Over the year, ECs and NAEs stayed elevated and fluctuated before slowly decreasing till the end of the deployment. The classical stress hormones showed small increases in the last third of deployment. By contrast, at Concordia (high altitude), norepinephrine concentrations increased significantly at the beginning (p < 0.001) which was paralleled by low EC levels. Prior to the second half of deployment, norepinephrine declined constantly to end on a low plateau level, whereas then the EC concentrations increased significantly in this second period during the overwintering (p < 0.001). Psychometric data showed no significant changes in the crews at either station. These findings demonstrate that exposition of healthy humans to the physically challenging extreme environment of Antarctica (i) has a distinct ... |
format |
Article in Journal/Newspaper |
author |
Strewe, Claudia Thieme, Detlef Dangoisse, Carole Fiedel, Barbara van den Berg, Floris Bauer, Holger Salam, Alex P Gössmann-Lang, Petra Campolongo, Patrizia Moser, Dominique Quintens, Roel Moreels, Marjan Baatout, Sarah Kohlberg, Eberhard Schelling, Gustav Choukèr, Alexander Feuerecker, Matthias |
author_facet |
Strewe, Claudia Thieme, Detlef Dangoisse, Carole Fiedel, Barbara van den Berg, Floris Bauer, Holger Salam, Alex P Gössmann-Lang, Petra Campolongo, Patrizia Moser, Dominique Quintens, Roel Moreels, Marjan Baatout, Sarah Kohlberg, Eberhard Schelling, Gustav Choukèr, Alexander Feuerecker, Matthias |
author_sort |
Strewe, Claudia |
title |
Modulations of neuroendocrine stress responses during confinement in Antarctica and the role of hypobaric hypoxia |
title_short |
Modulations of neuroendocrine stress responses during confinement in Antarctica and the role of hypobaric hypoxia |
title_full |
Modulations of neuroendocrine stress responses during confinement in Antarctica and the role of hypobaric hypoxia |
title_fullStr |
Modulations of neuroendocrine stress responses during confinement in Antarctica and the role of hypobaric hypoxia |
title_full_unstemmed |
Modulations of neuroendocrine stress responses during confinement in Antarctica and the role of hypobaric hypoxia |
title_sort |
modulations of neuroendocrine stress responses during confinement in antarctica and the role of hypobaric hypoxia |
publishDate |
2018 |
url |
https://biblio.ugent.be/publication/8600321 http://hdl.handle.net/1854/LU-8600321 https://doi.org/10.3389/fphys.2018.01647 https://biblio.ugent.be/publication/8600321/file/8600322 |
long_lat |
ENVELOPE(123.333,123.333,-75.100,-75.100) |
geographic |
Antarctic Concordia Station Neumayer The Antarctic |
geographic_facet |
Antarctic Concordia Station Neumayer The Antarctic |
genre |
Antarc* Antarctic Antarctica |
genre_facet |
Antarc* Antarctic Antarctica |
op_source |
FRONTIERS IN PHYSIOLOGY ISSN: 1664-042X |
op_relation |
https://biblio.ugent.be/publication/8600321 http://hdl.handle.net/1854/LU-8600321 http://dx.doi.org/10.3389/fphys.2018.01647 https://biblio.ugent.be/publication/8600321/file/8600322 |
op_rights |
No license (in copyright) info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3389/fphys.2018.01647 |
container_title |
Frontiers in Physiology |
container_volume |
9 |
_version_ |
1768377219820814336 |