How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime
European eels (Anguilla anguilla) undertake an impressive 5 000 km long migration from European fresh waters through the North Atlantic Ocean to the Sargasso Sea. Along with sexual maturation, the eel skeleton undergoes a remarkable morphological transformation during migration, where a hitherto com...
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ftunivgent:oai:archive.ugent.be:8525447 2023-06-11T04:03:43+02:00 How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime Rolvien, Tim Nagel, Florian Milovanovic, Petar Wuertz, Sven Marshall, Robert Percy Jeschke, Anke Schmidt, Felix N Hahn, Michael Witten, Paul Eckhard Amling, Michael Busse, Bjoern 2016 application/pdf https://biblio.ugent.be/publication/8525447 http://hdl.handle.net/1854/LU-8525447 https://doi.org/10.1098/rspb.2016.1550 https://biblio.ugent.be/publication/8525447/file/8643533 eng eng https://biblio.ugent.be/publication/8525447 http://hdl.handle.net/1854/LU-8525447 http://dx.doi.org/10.1098/rspb.2016.1550 https://biblio.ugent.be/publication/8525447/file/8643533 No license (in copyright) info:eu-repo/semantics/restrictedAccess PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES ISSN: 0962-8452 ISSN: 1471-2954 Biology and Life Sciences MEDAKA OSTEOPOROSIS MODEL SALMON SALMO-SALAR TELEOST FISH SEXUAL-MATURATION ATLANTIC SALMON ACELLULAR BONE 2ND-HARMONIC GENERATION DENSITY DISTRIBUTION SPAWNING MIGRATION VERTEBRAL SKELETON European eel bone loss osteoclasts journalArticle info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2016 ftunivgent https://doi.org/10.1098/rspb.2016.1550 2023-05-10T22:20:25Z European eels (Anguilla anguilla) undertake an impressive 5 000 km long migration from European fresh waters through the North Atlantic Ocean to the Sargasso Sea. Along with sexual maturation, the eel skeleton undergoes a remarkable morphological transformation during migration, where a hitherto completely obscure bone loss phenomenon occurs. To unravel mechanisms of the maturation-related decay of the skeleton, we performed a multiscale assessment of eels' bones at different life-cycle stages. Accordingly, the skeleton reflects extensive bone loss that is mediated via multinucleated bone-resorbing osteoclasts, while other resorption mechanisms such as osteocytic osteolysis or matrix demineralization were not observed. Preserving mechanical stability and releasing minerals for energy metabolism are two mutually exclusive functions of the skeleton that are orchestrated in eels through the presence of two spatially segregated hard tissues: cellular bone and acellular notochord. The cellular bone serves as a source of mineral release following osteoclastic resorption, whereas the mineralized notochord sheath, which is inaccessible for resorption processes due to an unmineralized cover layer, ensures sufficient mechanical stability as a part of the notochord sheath. Clearly, an eel's skeleton is structurally optimized to meet the metabolic challenge of fasting and simultaneous sexual development during an exhausting journey to spawning areas, while the function of the vertebral column is maintained to achieve this goal. Article in Journal/Newspaper Anguilla anguilla Atlantic salmon North Atlantic Salmo salar Ghent University Academic Bibliography Proceedings of the Royal Society B: Biological Sciences 283 1841 20161550 |
institution |
Open Polar |
collection |
Ghent University Academic Bibliography |
op_collection_id |
ftunivgent |
language |
English |
topic |
Biology and Life Sciences MEDAKA OSTEOPOROSIS MODEL SALMON SALMO-SALAR TELEOST FISH SEXUAL-MATURATION ATLANTIC SALMON ACELLULAR BONE 2ND-HARMONIC GENERATION DENSITY DISTRIBUTION SPAWNING MIGRATION VERTEBRAL SKELETON European eel bone loss osteoclasts |
spellingShingle |
Biology and Life Sciences MEDAKA OSTEOPOROSIS MODEL SALMON SALMO-SALAR TELEOST FISH SEXUAL-MATURATION ATLANTIC SALMON ACELLULAR BONE 2ND-HARMONIC GENERATION DENSITY DISTRIBUTION SPAWNING MIGRATION VERTEBRAL SKELETON European eel bone loss osteoclasts Rolvien, Tim Nagel, Florian Milovanovic, Petar Wuertz, Sven Marshall, Robert Percy Jeschke, Anke Schmidt, Felix N Hahn, Michael Witten, Paul Eckhard Amling, Michael Busse, Bjoern How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime |
topic_facet |
Biology and Life Sciences MEDAKA OSTEOPOROSIS MODEL SALMON SALMO-SALAR TELEOST FISH SEXUAL-MATURATION ATLANTIC SALMON ACELLULAR BONE 2ND-HARMONIC GENERATION DENSITY DISTRIBUTION SPAWNING MIGRATION VERTEBRAL SKELETON European eel bone loss osteoclasts |
description |
European eels (Anguilla anguilla) undertake an impressive 5 000 km long migration from European fresh waters through the North Atlantic Ocean to the Sargasso Sea. Along with sexual maturation, the eel skeleton undergoes a remarkable morphological transformation during migration, where a hitherto completely obscure bone loss phenomenon occurs. To unravel mechanisms of the maturation-related decay of the skeleton, we performed a multiscale assessment of eels' bones at different life-cycle stages. Accordingly, the skeleton reflects extensive bone loss that is mediated via multinucleated bone-resorbing osteoclasts, while other resorption mechanisms such as osteocytic osteolysis or matrix demineralization were not observed. Preserving mechanical stability and releasing minerals for energy metabolism are two mutually exclusive functions of the skeleton that are orchestrated in eels through the presence of two spatially segregated hard tissues: cellular bone and acellular notochord. The cellular bone serves as a source of mineral release following osteoclastic resorption, whereas the mineralized notochord sheath, which is inaccessible for resorption processes due to an unmineralized cover layer, ensures sufficient mechanical stability as a part of the notochord sheath. Clearly, an eel's skeleton is structurally optimized to meet the metabolic challenge of fasting and simultaneous sexual development during an exhausting journey to spawning areas, while the function of the vertebral column is maintained to achieve this goal. |
format |
Article in Journal/Newspaper |
author |
Rolvien, Tim Nagel, Florian Milovanovic, Petar Wuertz, Sven Marshall, Robert Percy Jeschke, Anke Schmidt, Felix N Hahn, Michael Witten, Paul Eckhard Amling, Michael Busse, Bjoern |
author_facet |
Rolvien, Tim Nagel, Florian Milovanovic, Petar Wuertz, Sven Marshall, Robert Percy Jeschke, Anke Schmidt, Felix N Hahn, Michael Witten, Paul Eckhard Amling, Michael Busse, Bjoern |
author_sort |
Rolvien, Tim |
title |
How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime |
title_short |
How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime |
title_full |
How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime |
title_fullStr |
How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime |
title_full_unstemmed |
How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime |
title_sort |
how the european eel (anguilla anguilla) loses its skeletal framework across lifetime |
publishDate |
2016 |
url |
https://biblio.ugent.be/publication/8525447 http://hdl.handle.net/1854/LU-8525447 https://doi.org/10.1098/rspb.2016.1550 https://biblio.ugent.be/publication/8525447/file/8643533 |
genre |
Anguilla anguilla Atlantic salmon North Atlantic Salmo salar |
genre_facet |
Anguilla anguilla Atlantic salmon North Atlantic Salmo salar |
op_source |
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES ISSN: 0962-8452 ISSN: 1471-2954 |
op_relation |
https://biblio.ugent.be/publication/8525447 http://hdl.handle.net/1854/LU-8525447 http://dx.doi.org/10.1098/rspb.2016.1550 https://biblio.ugent.be/publication/8525447/file/8643533 |
op_rights |
No license (in copyright) info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1098/rspb.2016.1550 |
container_title |
Proceedings of the Royal Society B: Biological Sciences |
container_volume |
283 |
container_issue |
1841 |
container_start_page |
20161550 |
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1768382332678438912 |