A cationic ruthenium complex for the dynamic kinetic resolution of secondary alcohols
A synthetic protocol making use of a well-defined cationic ruthenium complex 2 enabling the racemization of enantiomerically pure secondary alcohols in the presence of a weak base (K2CO3) is described. The compatibility of 2 with Candida Antarctica lipase B (Novozym 435) allows the development of an...
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ftunivgent:oai:archive.ugent.be:8168444 2023-06-11T04:05:39+02:00 A cationic ruthenium complex for the dynamic kinetic resolution of secondary alcohols Fernandez-Salas, Jose A Manzini, Simone Nolan, Steven 2014 https://biblio.ugent.be/publication/8168444 http://hdl.handle.net/1854/LU-8168444 https://doi.org/10.1002/chem.201404096 eng eng https://biblio.ugent.be/publication/8168444 http://hdl.handle.net/1854/LU-8168444 http://dx.doi.org/10.1002/chem.201404096 CHEMISTRY-A EUROPEAN JOURNAL ISSN: 0947-6539 Chemistry dynamic kinetic resolution enzyme catalysis metal catalysis racemization ruthenium CATALYTIC RACEMIZATION ASYMMETRIC TRANSFORMATIONS ENZYMATIC RESOLUTION AMBIENT-TEMPERATURE CHIRAL ACETATES ENOL ACETATES LIPASE KETONES ENZYMES journalArticle info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2014 ftunivgent https://doi.org/10.1002/chem.201404096 2023-05-10T22:40:08Z A synthetic protocol making use of a well-defined cationic ruthenium complex 2 enabling the racemization of enantiomerically pure secondary alcohols in the presence of a weak base (K2CO3) is described. The compatibility of 2 with Candida Antarctica lipase B (Novozym 435) allows the development of an efficient dynamic kinetic resolution of sec-alcohols in the absence of an additional strong base. This procedure involves the first example of a dynamic kinetic resolution of alcohols in the presence of a cationic ruthenium catalyst. In addition, we describe the conversion of ketones to the enantioenriched acetates in a one-pot reaction, probing the versatility of complex 2. Article in Journal/Newspaper Antarc* Antarctica Ghent University Academic Bibliography Chemistry - A European Journal 20 41 13132 13135 |
institution |
Open Polar |
collection |
Ghent University Academic Bibliography |
op_collection_id |
ftunivgent |
language |
English |
topic |
Chemistry dynamic kinetic resolution enzyme catalysis metal catalysis racemization ruthenium CATALYTIC RACEMIZATION ASYMMETRIC TRANSFORMATIONS ENZYMATIC RESOLUTION AMBIENT-TEMPERATURE CHIRAL ACETATES ENOL ACETATES LIPASE KETONES ENZYMES |
spellingShingle |
Chemistry dynamic kinetic resolution enzyme catalysis metal catalysis racemization ruthenium CATALYTIC RACEMIZATION ASYMMETRIC TRANSFORMATIONS ENZYMATIC RESOLUTION AMBIENT-TEMPERATURE CHIRAL ACETATES ENOL ACETATES LIPASE KETONES ENZYMES Fernandez-Salas, Jose A Manzini, Simone Nolan, Steven A cationic ruthenium complex for the dynamic kinetic resolution of secondary alcohols |
topic_facet |
Chemistry dynamic kinetic resolution enzyme catalysis metal catalysis racemization ruthenium CATALYTIC RACEMIZATION ASYMMETRIC TRANSFORMATIONS ENZYMATIC RESOLUTION AMBIENT-TEMPERATURE CHIRAL ACETATES ENOL ACETATES LIPASE KETONES ENZYMES |
description |
A synthetic protocol making use of a well-defined cationic ruthenium complex 2 enabling the racemization of enantiomerically pure secondary alcohols in the presence of a weak base (K2CO3) is described. The compatibility of 2 with Candida Antarctica lipase B (Novozym 435) allows the development of an efficient dynamic kinetic resolution of sec-alcohols in the absence of an additional strong base. This procedure involves the first example of a dynamic kinetic resolution of alcohols in the presence of a cationic ruthenium catalyst. In addition, we describe the conversion of ketones to the enantioenriched acetates in a one-pot reaction, probing the versatility of complex 2. |
format |
Article in Journal/Newspaper |
author |
Fernandez-Salas, Jose A Manzini, Simone Nolan, Steven |
author_facet |
Fernandez-Salas, Jose A Manzini, Simone Nolan, Steven |
author_sort |
Fernandez-Salas, Jose A |
title |
A cationic ruthenium complex for the dynamic kinetic resolution of secondary alcohols |
title_short |
A cationic ruthenium complex for the dynamic kinetic resolution of secondary alcohols |
title_full |
A cationic ruthenium complex for the dynamic kinetic resolution of secondary alcohols |
title_fullStr |
A cationic ruthenium complex for the dynamic kinetic resolution of secondary alcohols |
title_full_unstemmed |
A cationic ruthenium complex for the dynamic kinetic resolution of secondary alcohols |
title_sort |
cationic ruthenium complex for the dynamic kinetic resolution of secondary alcohols |
publishDate |
2014 |
url |
https://biblio.ugent.be/publication/8168444 http://hdl.handle.net/1854/LU-8168444 https://doi.org/10.1002/chem.201404096 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
CHEMISTRY-A EUROPEAN JOURNAL ISSN: 0947-6539 |
op_relation |
https://biblio.ugent.be/publication/8168444 http://hdl.handle.net/1854/LU-8168444 http://dx.doi.org/10.1002/chem.201404096 |
op_doi |
https://doi.org/10.1002/chem.201404096 |
container_title |
Chemistry - A European Journal |
container_volume |
20 |
container_issue |
41 |
container_start_page |
13132 |
op_container_end_page |
13135 |
_version_ |
1768377216690814976 |