Dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in Atlantic salmon (Salmo salar) postsmolts
Inflammation is a non-specific protective mechanism towards injury known to affect bone remodelling. This study aimed to investigate the effect of Freunds complete adjuvant (FCA) induced-inflammation on the prevalence of spinal deformities of Atlantic salmon postsmolts fed with two different dietary...
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ftunivgent:oai:archive.ugent.be:4090840 2023-06-11T04:10:14+02:00 Dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in Atlantic salmon (Salmo salar) postsmolts Martens, L Gil Fjelldal, PG Lock, E-J Wargelius, A Wergeland, H Witten, Paul Eckhard Hansen, T Waagbø, R Ørnsrud, R 2012 application/pdf https://biblio.ugent.be/publication/4090840 http://hdl.handle.net/1854/LU-4090840 https://doi.org/10.1111/j.1365-2095.2011.00871.x https://biblio.ugent.be/publication/4090840/file/5787536 eng eng https://biblio.ugent.be/publication/4090840 http://hdl.handle.net/1854/LU-4090840 http://dx.doi.org/10.1111/j.1365-2095.2011.00871.x https://biblio.ugent.be/publication/4090840/file/5787536 No license (in copyright) info:eu-repo/semantics/restrictedAccess AQUACULTURE NUTRITION ISSN: 1353-5773 Biology and Life Sciences phosphorus Salmo salar platyspondyly inflammation Freund adjuvant Freund's complete adjuvant bone Atlantic salmon spinal deformities EARLY SEAWATER PHASE VERTEBRAL DEFORMITIES CARBON-DIOXIDE POST-SMOLTS L GROWTH VACCINATION CYTOKINES COLUMN FISH journalArticle info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2012 ftunivgent https://doi.org/10.1111/j.1365-2095.2011.00871.x 2023-05-10T22:49:45Z Inflammation is a non-specific protective mechanism towards injury known to affect bone remodelling. This study aimed to investigate the effect of Freunds complete adjuvant (FCA) induced-inflammation on the prevalence of spinal deformities of Atlantic salmon postsmolts fed with two different dietary P levels. Sextuple groups of salmon postsmolts were fed with either a low-phosphorous (6 g kg-1 available P, LP) or a high-phosphorous (9 g kg-1 available P) diet for a period of 101 days. On Day 102, individually tagged fish were subjected to (i) single injection with FCA (0.125 mg kg-1 BW) dissolved in phosphate-buffered saline (PBS) (ii) placebo injection with PBS or (iii) sham injection (insertion of needle only) or (iv) remained untreated. On Day 103, fish were given a common diet for 174 days in seawater. No significant differences in body weight were observed. Injected fish, particularly the FCA group, had more compressions in the injection site than untreated fish. No effect of diet and no interaction between treatment and diet were observed. Severe scoliosis was observed in similar to 7% of FCA-injected individuals, corresponding to a mixture of bone malformations in the tail region. In conclusion, experimentally induced inflammation may be an independent risk factor for bone deformities in Atlantic salmon. Article in Journal/Newspaper Atlantic salmon Salmo salar Ghent University Academic Bibliography Aquaculture Nutrition 18 1 12 20 |
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Open Polar |
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Ghent University Academic Bibliography |
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ftunivgent |
language |
English |
topic |
Biology and Life Sciences phosphorus Salmo salar platyspondyly inflammation Freund adjuvant Freund's complete adjuvant bone Atlantic salmon spinal deformities EARLY SEAWATER PHASE VERTEBRAL DEFORMITIES CARBON-DIOXIDE POST-SMOLTS L GROWTH VACCINATION CYTOKINES COLUMN FISH |
spellingShingle |
Biology and Life Sciences phosphorus Salmo salar platyspondyly inflammation Freund adjuvant Freund's complete adjuvant bone Atlantic salmon spinal deformities EARLY SEAWATER PHASE VERTEBRAL DEFORMITIES CARBON-DIOXIDE POST-SMOLTS L GROWTH VACCINATION CYTOKINES COLUMN FISH Martens, L Gil Fjelldal, PG Lock, E-J Wargelius, A Wergeland, H Witten, Paul Eckhard Hansen, T Waagbø, R Ørnsrud, R Dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in Atlantic salmon (Salmo salar) postsmolts |
topic_facet |
Biology and Life Sciences phosphorus Salmo salar platyspondyly inflammation Freund adjuvant Freund's complete adjuvant bone Atlantic salmon spinal deformities EARLY SEAWATER PHASE VERTEBRAL DEFORMITIES CARBON-DIOXIDE POST-SMOLTS L GROWTH VACCINATION CYTOKINES COLUMN FISH |
description |
Inflammation is a non-specific protective mechanism towards injury known to affect bone remodelling. This study aimed to investigate the effect of Freunds complete adjuvant (FCA) induced-inflammation on the prevalence of spinal deformities of Atlantic salmon postsmolts fed with two different dietary P levels. Sextuple groups of salmon postsmolts were fed with either a low-phosphorous (6 g kg-1 available P, LP) or a high-phosphorous (9 g kg-1 available P) diet for a period of 101 days. On Day 102, individually tagged fish were subjected to (i) single injection with FCA (0.125 mg kg-1 BW) dissolved in phosphate-buffered saline (PBS) (ii) placebo injection with PBS or (iii) sham injection (insertion of needle only) or (iv) remained untreated. On Day 103, fish were given a common diet for 174 days in seawater. No significant differences in body weight were observed. Injected fish, particularly the FCA group, had more compressions in the injection site than untreated fish. No effect of diet and no interaction between treatment and diet were observed. Severe scoliosis was observed in similar to 7% of FCA-injected individuals, corresponding to a mixture of bone malformations in the tail region. In conclusion, experimentally induced inflammation may be an independent risk factor for bone deformities in Atlantic salmon. |
format |
Article in Journal/Newspaper |
author |
Martens, L Gil Fjelldal, PG Lock, E-J Wargelius, A Wergeland, H Witten, Paul Eckhard Hansen, T Waagbø, R Ørnsrud, R |
author_facet |
Martens, L Gil Fjelldal, PG Lock, E-J Wargelius, A Wergeland, H Witten, Paul Eckhard Hansen, T Waagbø, R Ørnsrud, R |
author_sort |
Martens, L Gil |
title |
Dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in Atlantic salmon (Salmo salar) postsmolts |
title_short |
Dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in Atlantic salmon (Salmo salar) postsmolts |
title_full |
Dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in Atlantic salmon (Salmo salar) postsmolts |
title_fullStr |
Dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in Atlantic salmon (Salmo salar) postsmolts |
title_full_unstemmed |
Dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in Atlantic salmon (Salmo salar) postsmolts |
title_sort |
dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in atlantic salmon (salmo salar) postsmolts |
publishDate |
2012 |
url |
https://biblio.ugent.be/publication/4090840 http://hdl.handle.net/1854/LU-4090840 https://doi.org/10.1111/j.1365-2095.2011.00871.x https://biblio.ugent.be/publication/4090840/file/5787536 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
AQUACULTURE NUTRITION ISSN: 1353-5773 |
op_relation |
https://biblio.ugent.be/publication/4090840 http://hdl.handle.net/1854/LU-4090840 http://dx.doi.org/10.1111/j.1365-2095.2011.00871.x https://biblio.ugent.be/publication/4090840/file/5787536 |
op_rights |
No license (in copyright) info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1111/j.1365-2095.2011.00871.x |
container_title |
Aquaculture Nutrition |
container_volume |
18 |
container_issue |
1 |
container_start_page |
12 |
op_container_end_page |
20 |
_version_ |
1768384536126685184 |