Compressed vertebrae in Atlantic salmon Salmo salar : evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny
Anterior/posterior (a/p) compression of the vertebral column, referred to as 'short tails', is a recurring event in farmed Atlantic salmon. Like other skeletal deformities, the problem usually becomes evident in a late life phase, too late for preventive measures, making it difficult to un...
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ftunivgent:oai:archive.ugent.be:336148 2023-10-01T03:54:46+02:00 Compressed vertebrae in Atlantic salmon Salmo salar : evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny Witten, Paul Gil-Martens, Laura Hall, Brian K. Huysseune, Ann Obach, Alex 2005 application/pdf https://biblio.ugent.be/publication/336148 http://hdl.handle.net/1854/LU-336148 https://doi.org/10.3354/dao064237 https://biblio.ugent.be/publication/336148/file/8668662 eng eng https://biblio.ugent.be/publication/336148 http://hdl.handle.net/1854/LU-336148 http://dx.doi.org/10.3354/dao064237 https://biblio.ugent.be/publication/336148/file/8668662 No license (in copyright) info:eu-repo/semantics/openAccess DISEASES OF AQUATIC ORGANISMS ISSN: 0177-5103 ISSN: 1616-1580 Biology and Life Sciences journalArticle info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2005 ftunivgent https://doi.org/10.3354/dao064237 2023-09-06T22:34:35Z Anterior/posterior (a/p) compression of the vertebral column, referred to as 'short tails', is a recurring event in farmed Atlantic salmon. Like other skeletal deformities, the problem usually becomes evident in a late life phase, too late for preventive measures, making it difficult to understand the aetiology of the disease. We use structural, radiological, histological, and mineral analyses to study 'short tail' adult salmon and to demonstrate that the study of adult fish can provide important insights into earlier developmental processes. 'Short tails' display a/p compressed vertebrae throughout the spine, except for the first post-cranial vertebrae. The vertebral number is unaltered, but the intervertebral space is reduced and the vertebrae are shorter. Compressed vertebrae are characterized by an unchanged central part, altered vertebral end plates (straight instead of funnel-shaped), an atypical inward bending of the vertebral edges, and structural alterations in the intervertebral tissue. The spongiosa is unaffected. The growth zones of adjacent vertebrae fuse and blend towards the intervertebral space into chondrogenic tissue. This tissue produces different types of cartilage, replacing the notochord. The correspondence in location of intervertebral cartilage and deformed vertebral end plates, and the clearly delimited, unaltered, central vertebral parts suggest that the a/p compression of vertebral bodies is a late developmental disorder that may be related to a metaplastic shift of osteogenic tissue into chondrogenic tissue in the vertebral growth zone. Given the lack of evidence for infections, metabolic disorders and/or genetic disorders, we propose that an altered mechanical load could have caused the transformation of the bone growth zones and the concomitant replacement of the intervertebral (notochord) tissue by cartilaginous tissues in the 'short tails' studied here. This hypothesis is supported by the role that notochord cells are known to play in spine development and in maintaining the ... Article in Journal/Newspaper Atlantic salmon Salmo salar Ghent University Academic Bibliography Diseases of Aquatic Organisms 64 237 246 |
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Ghent University Academic Bibliography |
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language |
English |
topic |
Biology and Life Sciences |
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Biology and Life Sciences Witten, Paul Gil-Martens, Laura Hall, Brian K. Huysseune, Ann Obach, Alex Compressed vertebrae in Atlantic salmon Salmo salar : evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny |
topic_facet |
Biology and Life Sciences |
description |
Anterior/posterior (a/p) compression of the vertebral column, referred to as 'short tails', is a recurring event in farmed Atlantic salmon. Like other skeletal deformities, the problem usually becomes evident in a late life phase, too late for preventive measures, making it difficult to understand the aetiology of the disease. We use structural, radiological, histological, and mineral analyses to study 'short tail' adult salmon and to demonstrate that the study of adult fish can provide important insights into earlier developmental processes. 'Short tails' display a/p compressed vertebrae throughout the spine, except for the first post-cranial vertebrae. The vertebral number is unaltered, but the intervertebral space is reduced and the vertebrae are shorter. Compressed vertebrae are characterized by an unchanged central part, altered vertebral end plates (straight instead of funnel-shaped), an atypical inward bending of the vertebral edges, and structural alterations in the intervertebral tissue. The spongiosa is unaffected. The growth zones of adjacent vertebrae fuse and blend towards the intervertebral space into chondrogenic tissue. This tissue produces different types of cartilage, replacing the notochord. The correspondence in location of intervertebral cartilage and deformed vertebral end plates, and the clearly delimited, unaltered, central vertebral parts suggest that the a/p compression of vertebral bodies is a late developmental disorder that may be related to a metaplastic shift of osteogenic tissue into chondrogenic tissue in the vertebral growth zone. Given the lack of evidence for infections, metabolic disorders and/or genetic disorders, we propose that an altered mechanical load could have caused the transformation of the bone growth zones and the concomitant replacement of the intervertebral (notochord) tissue by cartilaginous tissues in the 'short tails' studied here. This hypothesis is supported by the role that notochord cells are known to play in spine development and in maintaining the ... |
format |
Article in Journal/Newspaper |
author |
Witten, Paul Gil-Martens, Laura Hall, Brian K. Huysseune, Ann Obach, Alex |
author_facet |
Witten, Paul Gil-Martens, Laura Hall, Brian K. Huysseune, Ann Obach, Alex |
author_sort |
Witten, Paul |
title |
Compressed vertebrae in Atlantic salmon Salmo salar : evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny |
title_short |
Compressed vertebrae in Atlantic salmon Salmo salar : evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny |
title_full |
Compressed vertebrae in Atlantic salmon Salmo salar : evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny |
title_fullStr |
Compressed vertebrae in Atlantic salmon Salmo salar : evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny |
title_full_unstemmed |
Compressed vertebrae in Atlantic salmon Salmo salar : evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny |
title_sort |
compressed vertebrae in atlantic salmon salmo salar : evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny |
publishDate |
2005 |
url |
https://biblio.ugent.be/publication/336148 http://hdl.handle.net/1854/LU-336148 https://doi.org/10.3354/dao064237 https://biblio.ugent.be/publication/336148/file/8668662 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
DISEASES OF AQUATIC ORGANISMS ISSN: 0177-5103 ISSN: 1616-1580 |
op_relation |
https://biblio.ugent.be/publication/336148 http://hdl.handle.net/1854/LU-336148 http://dx.doi.org/10.3354/dao064237 https://biblio.ugent.be/publication/336148/file/8668662 |
op_rights |
No license (in copyright) info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3354/dao064237 |
container_title |
Diseases of Aquatic Organisms |
container_volume |
64 |
container_start_page |
237 |
op_container_end_page |
246 |
_version_ |
1778522684478455808 |