Psoriasis: Clinical manifestations, pathogenesis and therapeutic perspectives
Extract: Psoriasis, a common inflammatory skin disorder, has recently moved into the limelight of both basic and clinical research. On the one hand, research into its pathogenesis has furthered our general understanding of T cell-mediated autoimmune disorders, and, on the other hand, psoriasis is us...
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ftunivgeneve:oai:unige.ch:unige:29719 2023-05-15T15:09:25+02:00 Psoriasis: Clinical manifestations, pathogenesis and therapeutic perspectives Schon, Michael P. Boehncke, Wolf-Henning Brocker, Eva B. 2005 https://archive-ouverte.unige.ch/unige:29719 eng eng info:eu-repo/semantics/altIdentifier/pmid/20704884 unige:29719 https://archive-ouverte.unige.ch/unige:29719 info:eu-repo/semantics/ ISSN: 1539-6509 Discovery medicine, Vol. 5, No 27 (2005) pp. 253-258 Text Article scientifique info:eu-repo/semantics/article info:eu-repo/semantics/metadataOnly 2005 ftunivgeneve 2022-06-19T23:38:55Z Extract: Psoriasis, a common inflammatory skin disorder, has recently moved into the limelight of both basic and clinical research. On the one hand, research into its pathogenesis has furthered our general understanding of T cell-mediated autoimmune disorders, and, on the other hand, psoriasis is used increasingly as a primary target disorder for novel therapies that are pathogenesis-oriented. Given that psoriasis affects approximately 2% of the population, it is a truly common skin disease. It is, therefore, somewhat surprising that the first description of psoriasis as a distinct entity dates back only to the year 1841. Geographic and ethnic factors appear to have a significant influence on the prevalence of psoriasis: ranges from 0% in the population of the Pacific islands of Samoa to 12% in the Arctic Kasach'ye have been reported. Ethnic influence is particularly evident when looking at the prevalence in African Americans, which is less than half that of the United States in general. Numerous family studies have provided compelling evidence for a genetic predisposition to develop psoriasis, although the inheritance pattern is still unclear. Genome-wide linkage studies have identified several putative psoriasis susceptibility loci, one of which located in the MHC (major histocompatibility complex, a cluster/locus of genes involved in the immune response of rejection) region on chromosome 6 was found to be present in several populations. This locus, termed "PSORiasis Susceptibility 1" (PSORS1), can thus be considered the major susceptibility locus and is associated with up to 50% of psoriasis cases. Article in Journal/Newspaper Arctic Université de Genève: Archive ouverte UNIGE Arctic Pacific |
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Extract: Psoriasis, a common inflammatory skin disorder, has recently moved into the limelight of both basic and clinical research. On the one hand, research into its pathogenesis has furthered our general understanding of T cell-mediated autoimmune disorders, and, on the other hand, psoriasis is used increasingly as a primary target disorder for novel therapies that are pathogenesis-oriented. Given that psoriasis affects approximately 2% of the population, it is a truly common skin disease. It is, therefore, somewhat surprising that the first description of psoriasis as a distinct entity dates back only to the year 1841. Geographic and ethnic factors appear to have a significant influence on the prevalence of psoriasis: ranges from 0% in the population of the Pacific islands of Samoa to 12% in the Arctic Kasach'ye have been reported. Ethnic influence is particularly evident when looking at the prevalence in African Americans, which is less than half that of the United States in general. Numerous family studies have provided compelling evidence for a genetic predisposition to develop psoriasis, although the inheritance pattern is still unclear. Genome-wide linkage studies have identified several putative psoriasis susceptibility loci, one of which located in the MHC (major histocompatibility complex, a cluster/locus of genes involved in the immune response of rejection) region on chromosome 6 was found to be present in several populations. This locus, termed "PSORiasis Susceptibility 1" (PSORS1), can thus be considered the major susceptibility locus and is associated with up to 50% of psoriasis cases. |
format |
Article in Journal/Newspaper |
author |
Schon, Michael P. Boehncke, Wolf-Henning Brocker, Eva B. |
spellingShingle |
Schon, Michael P. Boehncke, Wolf-Henning Brocker, Eva B. Psoriasis: Clinical manifestations, pathogenesis and therapeutic perspectives |
author_facet |
Schon, Michael P. Boehncke, Wolf-Henning Brocker, Eva B. |
author_sort |
Schon, Michael P. |
title |
Psoriasis: Clinical manifestations, pathogenesis and therapeutic perspectives |
title_short |
Psoriasis: Clinical manifestations, pathogenesis and therapeutic perspectives |
title_full |
Psoriasis: Clinical manifestations, pathogenesis and therapeutic perspectives |
title_fullStr |
Psoriasis: Clinical manifestations, pathogenesis and therapeutic perspectives |
title_full_unstemmed |
Psoriasis: Clinical manifestations, pathogenesis and therapeutic perspectives |
title_sort |
psoriasis: clinical manifestations, pathogenesis and therapeutic perspectives |
publishDate |
2005 |
url |
https://archive-ouverte.unige.ch/unige:29719 |
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Arctic Pacific |
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Arctic Pacific |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
ISSN: 1539-6509 Discovery medicine, Vol. 5, No 27 (2005) pp. 253-258 |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/20704884 unige:29719 https://archive-ouverte.unige.ch/unige:29719 |
op_rights |
info:eu-repo/semantics/ |
_version_ |
1766340613356126208 |